A5101786248- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Pancreatic and Hepatic Oncology Research
- Parkinson's Disease Mechanisms and Treatments
- Gastrointestinal Tumor Research and Treatment
- Winter Sports Injuries and Performance
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Acute Ischemic Stroke Management
- Autophagy in Disease and Therapy
- Inflammatory Biomarkers in Disease Prognosis
- SARS-CoV-2 detection and testing
- Bacterial biofilms and quorum sensing
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Sleep and Wakefulness Research
- Saffron Plant Research Studies
- Mechanisms of cancer metastasis
- Infection Control and Ventilation
- Cancer Mechanisms and Therapy
- Restless Legs Syndrome Research
- Vascular Malformations and Hemangiomas
- Palliative and Oncologic Care
- Facial Nerve Paralysis Treatment and Research
- Brain Metastases and Treatment
- Neurological disorders and treatments
Fudan University
2009-2025
Huashan Hospital
2019-2025
West China Hospital of Sichuan University
2022-2024
Sichuan University
2022-2024
Jilin University
2023
First Hospital of Jilin University
2023
Qilu Hospital of Shandong University
2022
Creative Commons
2022
Hebei Provincial Center for Disease Control and Prevention
2022
Texas Tech University
2022
Background There is a close relationship between radiotherapy and autophagy in tumors, but the prognostic role of radiotherapy-related genes (RRAGs) lung adenocarcinoma (LUAD) remains unclear. Methods Data used current study were extracted from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. Weighted gene co-expression network analysis (WGCNA) was executed to recognize module associated with radiotherapy. differentially expressed (DEGs) different response groups...
Background Smoking is a significant risk factor for neurological disorders, yet its global impact on these conditions remains underexplored. Methods Using Global Burden of Diseases 2021 data, we analysed trends in age-standardised disability-adjusted life-years (DALYs) and deaths attributable to smoking from 1990 three disorders: stroke, Alzheimer’s disease other dementias, Multiple Sclerosis. Socioeconomic disparities were assessed using the lope index inequality relative concentration...
Background and purpose The of this study was to evaluate the prognostic value radiomics-based hyperdense middle cerebral artery sign (HMCAS) for patients with acute ischemic stroke (AIS) after mechanical thrombectomy (MT) establish prediction models identify who may benefit more from MT. Methods In retrospective study, a total 102 consecutive presented HMCAS on non-contrast computed tomography (NCCT) at admission underwent MT in our hospital between January 2019 December 2020 were recruited....
The severe acute respiratory syndrome related coronavirus 2 (SARS-CoV-2) has spread globally and there is still a lack of rapid detection techniques for SARS-CoV-2 surveillance in indoor air. In this work, two test rigs were developed that enable continuous air monitoring the by sample collection testing. collected samples from simulated contaminated analyzed using an ultra-fast COVID-19 diagnostic sensor (UFC-19). utilized sampling methods: cyclone-based internal impaction. former achieved...
The Alberta Stroke Program Early Computed Tomography Score (ASPECTS) was designed for semi-quantitative assessment of early ischemic changes on non-contrast computed tomography (NCCT) acute stroke (AIS). We evaluated two automated ASPECTS software in comparison with reference standard.NCCT 276 AIS patients were retrospectively reviewed (March 2018-June 2020). A three-radiologist consensus used as standard. Imaging data from both baseline and follow-up Automated calculated NCCT 1-mm 5-mm...
Steroid profiling was introduced to determine the endogenous steroid misuse in sports. Thus, screening for exogenous use of these prohibited substances can be established by monitoring a range steroids, which constitute profile and evaluate their concentrations ratios against reference values. The is currently based on population statistics. As large interindividual variations exist, athlete biological passport (ABP) analysis ongoing. This study aimed identify new biomarker(s) aromatase...
To investigate the predictive value of intramuscular adipose tissue content (IMAC) on outcome gallbladder cancer (GBC) patients after resection, by then develop and evaluate a nomogram to predict prognosis GBC patients.This research incorporated 123 with pathological diagnosis GBC. Evaluating Kaplan-Meier method. Independent predictors overall survival (OS) were screened using multifactorial Cox regression analysis, was constructed from these. Consistency index calibration curve used...
Background:Objective motor ratings and subjective complaints are both widely used in Parkinson's disease (PD). However, the objective basis to self-perceived mobility quality is still not well elucidated. Purposes: We aimed figure out relevancy between UPDRS scores PDQ39 sub-scores, further explore whether physician-assessed dysfunctions patients-reported deficits have some shared mechanisms. Methods: 49 patients with PD who completed scale were retrospectively included. The was assessed, as...
Laparoscopic pancreaticoduodenectomy (LPD) with superior mesenteric/portal vein (SMV/PV) resection and reconstruction was the most technically challenging procedure had been rarely reported. However, single-incision plus one-port LPD (SILPD +1) SMV/PV has never In this study, we will demonstrate feasibility, safety, key surgical procedure, long-term outcomes for SILPD +1 using video evidence. Two cases of wedge were carried out by authors. There no tumor recurrence during one-year follow-up....
Staphylococcus aureus (S. aureus) is a common opportunistic and zoonotic pathogen in the world could easily cause human infections food contaminations. This study investigated sequence typing resistance profiles of S. isolates from patient samples Shijiazhuang, China. A total 101 were distributed into six clonal complexes (CCs) 16 singletons. 86 CCs 12 singletons, including new ST. CC59, CC5, CC22, CC398 predominant isolates. 15 foodborne 3 4 STs, CC1 was most prevalent CC. Moreover, had...
Abstract Objective To investigate the efficacy and prognostic factors of treatment brain metastases (BMs) non-small-cell lung cancer (NSCLC) patients with hypofractionated stereotactic radiotherapy (HSRT) based on linear accelerators. Methods A total 80 NSCLC BMs were treated HSRT under image guidance tomotherapy (TOMO) or volumetric modulated arc therapy (VMAT) in Yunnan Cancer Hospital from Jan 1 st , 2017 to Aug 7 th 2019. The outcome measures included overall survival (OS), intracranial...
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<div>Abstract<p>Histone modification determines epigenetic patterns of gene expression with methylation histone H3 at lysine 4 (H3K4) often associated active promoters. LSD1/KDM1 is a demethylase that suppresses by converting dimethylated H3K4 to mono- and unmethylated H3K4. LSD1 essential for metazoan development, but its pathophysiologic functions in cancer remain mainly uncharacterized. In this study, we developed specific bioactive small inhibitors enhance derepress...
<div>Abstract<p>Histone modification determines epigenetic patterns of gene expression with methylation histone H3 at lysine 4 (H3K4) often associated active promoters. LSD1/KDM1 is a demethylase that suppresses by converting dimethylated H3K4 to mono- and unmethylated H3K4. LSD1 essential for metazoan development, but its pathophysiologic functions in cancer remain mainly uncharacterized. In this study, we developed specific bioactive small inhibitors enhance derepress...
<p>PDF file - 102K</p>
Acute myeloid leukemia (AML) is a hematologic malignancy characterized by the abnormal proliferation of hematopoietic cells and it urgently needed to develop new molecular biomarkers predict clinical outcomes improve therapeutic effects.The differentially expressed genes were identified comparing TCGA with GETx data. Univariate LASSO multivariate cox regression analysis performed identify prognosis-associated pseudogenes. Based on overall survival related pseudogenes, we used them construct...