A5064885176- Multiple Myeloma Research and Treatments
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cytokine Signaling Pathways and Interactions
- Melanoma and MAPK Pathways
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- HER2/EGFR in Cancer Research
- RNA modifications and cancer
Sun Yat-sen University
2022-2023
Sun Yat-sen University Cancer Center
2022-2023
Guangzhou Institutes of Biomedicine and Health
2022
Chinese Academy of Sciences
2022
University of Chinese Academy of Sciences
2022
First People's Hospital of Foshan
2022
Shenyang Pharmaceutical University
2014
Among patients with triple-negative breast cancer (TNBC), distant metastasis is the leading cause of death. Our previous studies have shown that TNBC progression greatly facilitated by circKIF4A, but uncertainty remains regarding its role in brain and molecular mechanism. In this study, we found notable upregulation circKIF4A cell lines metastases. Inhibition impaired ability to proliferate, migrate, metastasis. Luciferase reporter assays confirmed competed for binding miR-637 STAT3 3’ UTR....
Triple-negative breast cancer (TNBC) is the subtype with worst prognosis of cancer. Ferroptosis, a novel iron-dependent programmed cell death, has an increasingly important role in tumorigenesis and development. However, there still lack research on relationship between ferroptosis-related genes TNBC. In this study, we obtained gene expression profile TNBC patients matched clinical data from The Cancer Genome Atlas (TCGA) database. Univariate Cox analysis was used to screen out associated...
The first examples of threonine tyrosine kinase (TTK) PROTACs were designed and synthesized. Two the most potent molecules, 8e 8j, demonstrated strong TTK degradation in COLO-205 human colorectal cancer cells with DC50 values 1.7 3.1 nM, respectively. Proteasome-mediated by compounds could last for approximately 8 h after washout. degraders 8j improved antiproliferative activities comparing structurally similar inhibitor counterparts 8q 8r. Degraders also reasonable PK profiles exhibited...
Epidermal growth factor receptor (EGFR) amplification has been demonstrated to be critical for the inherent and/or acquired resistance against current B-RafV600E inhibitor therapy melanoma and colorectal cancer patients. We describe discovery structure–activity relationship study of a series 1H-pyrazolo[3,4-b]pyridine-5-carboxamide analogues as novel dual inhibitors EGFR mutant. One most promising compounds, 6a, potently inhibited both kinases with IC50 values 8.0 51 nM, respectively. The...
Pan-bromodomain and extra terminal (Pan-BET) inhibitors show profound efficacy but exhibit pharmacology-driven toxicities in clinical trials. The development of domain-selective BET to separate toxicity is urgently needed. Herein, we report a series furo[3,2-c]pyridin-4(5H)-one derivatives as novel BD2-selective inhibitors. representative compound 8l (XY153) potently bound BRD4 BD2 with an half-maximum inhibitory concentration (IC50) value 0.79 nM displayed 354-fold selectivity over BD1....
Abstract Background Among patients with triple-negative breast cancer (TNBC), distant metastasis is the leading cause of death. Our previous studies have shown that TNBC progression greatly facilitated by circKIF4A, but uncertainty remains regarding role which in brain and its molecular mechanism. Methods In this study, RNA sequencing was used to identify circKIF4A from 22 pairs primary metastases. Validation expression existence performed using FISH RT-qPCR assays. It demonstrated plays an...