A5045375905- Dementia and Cognitive Impairment Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Alzheimer's disease research and treatments
- Digital Mental Health Interventions
- Mental Health Research Topics
- Intracranial Aneurysms: Treatment and Complications
- Child and Adolescent Psychosocial and Emotional Development
- Traumatic Brain Injury Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Systemic Lupus Erythematosus Research
- Mental Health Treatment and Access
- S100 Proteins and Annexins
- Memory and Neural Mechanisms
- Impact of Technology on Adolescents
- Cerebrovascular and Carotid Artery Diseases
- Neurobiology of Language and Bilingualism
- Trauma and Emergency Care Studies
- Neural and Behavioral Psychology Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Functional Brain Connectivity Studies
- Vitamin D Research Studies
- Advanced Neuroimaging Techniques and Applications
- Eating Disorders and Behaviors
UiT The Arctic University of Norway
2016-2025
University Hospital of North Norway
2016-2025
Centre for Arctic Gas Hydrate, Environment and Climate
2014
Rigshospitalet
2008-2013
SINTEF
2008
Carnegie Mellon University
2008
The University of Texas at Austin
2008
Neurology, Inc
2005
University of Bergen
2003
Haukeland University Hospital
2003
The objective of the present study was to examine cross-sectional relation between serum 25-hydroxyvitamin D [25-(OH) D] levels and depression in overweight obese subjects assess effect vitamin supplementation on depressive symptoms.Cross-sectional randomized double blind controlled trial 20,000 or 40,000 IU per week versus placebo for 1 year.A total 441 (body mass index 28-47 kg m(-2), 159 men 282 women, aged 21-70 years) recruited by advertisements from out-patient clinic at University...
Neuronal and glial cell interaction is essential for synaptic homeostasis may be affected in Alzheimer's disease (AD). We measured cerebrospinal fluid (CSF) neuronal glia markers along the AD continuum, to reveal putative protective or harmful stage-dependent patterns of activation.We included healthy controls (n = 36) Aβ-positive (Aβ+) cases (as defined by pathological CSF amyloid beta 1-42 (Aβ42)) with either subjective cognitive decline (SCD, n 19), mild impairment (MCI, 39), dementia...
Abstract Staging amyloid-beta (Aβ) pathophysiology according to the intensity of neurodegeneration could identify individuals at risk for cognitive decline in Alzheimer’s disease (AD). In blood, phosphorylated tau (p-tau) associates with Aβ but an AD-type biomarker has been lacking. this multicenter study ( n = 1076), we show that brain-derived (BD-tau) blood increases concomitant (“A”) and (“N”) abnormalities (determined using cerebrospinal fluid biomarkers); We used blood-based A/N...
OBJECTIVE To investigate the role of prophylactic hyperdynamic postoperative fluid therapy in preventing delayed ischemic neurological deficits attributable to cerebral vasospasm. METHODS We designed a prospected, randomized, controlled study and included 32 patients with subarachnoid hemorrhage. Sixteen received hypervolemic hypertensive hemodilution therapy; other 16 normovolemic therapy. All were monitored for at least 12 days, clinical assessments, transcranial Doppler recordings,...
Abstract Objective: Our objective was to examine the relation between neuropsychological function and subclinical hypothyroidism (SHT), defined as serum TSH of 3.5–10.0 mIU/liter normal free T4 T3 levels, study effect supplementation. Subjects: A total 89 subjects (45 males) with SHT 154 control (72 were recruited from a general health survey (the fifth Tromsø study). Sixty-nine those included in placebo-controlled, double-blind intervention medication for 1 yr. Main Outcome Measures: We...
OBJECTIVE The present study was conducted to validate S-100 protein as a marker of brain damage after minor head injury. METHODS We studied 50 patients with injuries and Glasgow Coma Scale scores 13 15 in whom computed tomographic scans the revealed no abnormalities. Serum levels were measured at admittance hourly thereafter until 12 hours Magnetic resonance imaging baseline neuropsychological examinations performed within 48 hours, follow-up 3 months postinjury. RESULTS Fourteen (28%) had...
To determine whether neuropsychiatric manifestations in patients with systemic lupus erythematosus (SLE) are influenced by antibodies against the human N‐methyl‐ d ‐aspartate (NMDA) receptor types NR2a or NR2b. A decapeptide was synthesized containing a sequence motif present extracellular ligand‐binding domain of NMDA receptors and NR2b, bound monoclonal murine anti‐DNA antibody R4A. In an ELISA R4v as positive control, plasma samples 57 SLE were examined for anti‐peptide (anti‐NR2) after...
<b><i>Objective:</i></b> To assess the relationship between asymptomatic carotid stenosis, neuropsychological test performance, and silent MRI lesions. <b><i>Methods:</i></b> Performance on several tests was compared in 189 subjects with ultrasound-assessed stenosis 201 control without recruited from a population health study. Subjects previous history of stroke were excluded. The battery included attention, psychomotor speed, memory, language, speed information processing, motor...
To compare depressive symptoms in participants with low and high serum 25-hydroxyvitamin D (25(OH)D) levels to examine whether supplementation vitamin D(3) would improve those 25(OH)D levels.Participants were randomised either placebo or 40 000 IU per week for 6 months. Individuals used as nested controls. Depressive evaluated the Beck Depression Inventory, Hospital Anxiety Scale, Seasonal Pattern Assessment Scale Montgomery-Åsberg Rating Scale. The study was registered at ClinicalTrials.gov...
Background and Purpose— Cerebral artery aneurysms rupture when wall tension exceeds the strength of tissue. At present, risk-assessment unruptured does not include evaluation lesions shape, yet clinical experience suggests that this is importance. We aimed to develop a computational model for simulation fluid-structure interaction in cerebral based on patient specific lesion geometry, with special emphasis tension. Methods— An advanced isogeometric analysis incorporating flexible aneurysm...
Background: Mild head injury (MHI) implies a risk for traumatic brain and even small development of an intracranial hematoma. Head computed tomography (CT) is recommended early detection such pathologic findings. The present multicenter study was performed to investigate whether determination protein S100B in serum could contribute the selection patients CT scanning. Methods: We included 226 with history Glasgow Coma Scale (GCS) score 13 15 at admission hospital. Blood samples analysis were...
The Internet has the potential to increase capacity and accessibility of mental health services. This study aimed investigate whether an unguided Internet‐based self‐help intervention delivered without human support or guidance can reduce symptoms depression in young people at risk depression. also explore usage such sites a real‐life setting, estimate effects for those who received meaningful dose evaluate user satisfaction. Young adults were recruited by means screening survey sent all...
Background: Most patients with mild to moderate depression receive treatment in primary care, but despite guideline recommendations, structured psychological interventions are infrequently delivered. Research supports the effectiveness of Internet-based for depression; however, few trials have studied effect MoodGYM program plus therapist support. The use such could improve delivery care. Objective: To evaluate and acceptability a guided Web-based intervention depression, which be suitable...
Internet-based cognitive behavioural therapy (ICBT) is a promising approach to the prevention and reduction of depressive symptoms among adolescents. This study aimed evaluate feasibility efficacy disseminating self-directed internet-based mental health intervention (MoodGYM) in senior high schools. It also sought investigate possible effects tailored weekly e-mail reminders on initial uptake adherence intervention. A baseline survey was conducted four schools two Norwegian municipalities (n...
The prevalence of depression is high and results in huge costs for society. Internet-based cognitive behavioural treatment (ICBT) has been suggested use primary care shown to be more effective when combined with human support. However, non-completion rates remain a challenge. Current recommendations state that steps improve persistence ICBT should determined the impact therapist support on explored. A few earlier studies have explored motivations persist without face-to-face present study...
Abstract The Young Schema Questionnaire (YSQ) and the Temperament Character Inventory (TCI) have been suggested as vulnerability markers for depression. One‐ hundred forty clinically depressed subjects(CD), previously subjects(PD) never (ND) controls completed YSQ, TCI Beck Depression Inventory. Results showed that CD PD differed significantly on early maladaptive schemas, temperament character traits compared with ND. In accordance previous research, higher levels of harm avoidance lower...
The objective of this study is to evaluate internal consistency and psychometric properties the Hospital Anxiety Depression Scale ( HADS ), Beck inventory‐ II BDI ‐ ) Montgomery Åsberg Rating MADRS for screening major depressive episode MDE in a selected sample from healthy population. Participants answered questionnaires were interviewed with . Structured Clinical Interview Diagnostic Statistical Manual Mental Disorders DSM )‐ IV Axis I Disorders‐Clinician Version SCID CV was used diagnose...
Depression is common and treatable with cognitive behavior therapy (CBT), for example. However, access to this limited. Internet-based interventions have been found be effective in reducing symptoms of depression. The International Society Research on Internet Interventions has highlighted the importance translating programs into multiple languages enable worldwide dissemination.The aim current study was determine if it would cost translate an existing English-language intervention use a...
Aligning biomarker evidence with clinical presentation in early Alzheimer disease (AD) is essential for improving diagnosis, prognosis, and interventions. This study evaluates the relationship between cognitive impairment, future decline, phosphorylated tau levels plasma CSF predementia AD. longitudinal observational included cases controls from 2 independent cohorts: Norwegian Dementia Disease Initiation (DDI) Canadian Pre-Symptomatic Evaluation of Experimental or Novel Treatments...