A5100659852- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Animal Vocal Communication and Behavior
- Neuroscience of respiration and sleep
- Data Stream Mining Techniques
- Connexins and lens biology
- Hearing Loss and Rehabilitation
- Neural dynamics and brain function
- Distributed and Parallel Computing Systems
- Ion channel regulation and function
- Marine animal studies overview
- Scientific Computing and Data Management
- Neuroscience and Music Perception
Allen Institute
2023
Johns Hopkins Medicine
2022
Johns Hopkins University
2022
Massachusetts Eye and Ear Infirmary
2016
Harvard University
2016
Boston Children's Hospital
2016
Massachusetts Institute of Technology
2012-2016
Harvard University Press
2012
Inner ear sensory epithelia contain mechanosensitive hair cells that transmit information to the brain through innervation with bipolar neurons. Mammalian do not regenerate and are limited in number. Here we investigate potential generate from mouse embryonic stem a three-dimensional (3D) culture system. The system faithfully recapitulates inner induction followed by self-guided development into organoids morphologically resemble vestibular organs. We find organoid acquire mechanosensitivity...
Pharmacological studies suggest that dopamine release from lateral olivocochlear efferent neurons suppresses spontaneous and sound-evoked activity in cochlear nerve fibers helps control noise-induced excitotoxicity; however, the literature on expression localization of receptors is contradictory. To better characterize dopaminergic signaling, we studied receptor using immunohistochemistry or reverse transcriptase PCR assessed histopathology, responses function mice with targeted deletion...
Firing patterns differ between subpopulations of vestibular primary afferent neurons. The role sodium (NaV) channels in this diversity has not been investigated because NaV currents rodent ganglion neurons (VGNs) were reported to be homogeneous, with the voltage dependence and tetrodotoxin (TTX) sensitivity most neuronal channels. RT-PCR experiments, however, indicated expression diverse channel subunits ganglion, motivating a closer look. Whole cell recordings from acutely dissociated...
This paper introduces Cybershuttle, a new type of user-facing cyberinfrastructure that provides seamless access to range resources for researchers, enhancing their productivity. The Cybershuttle Research Environment is built on open source Apache Airavata software and uses hybrid approach integrates locally deployed agent programs with centrally hosted middleware. enables end-to-end integration computational science engineering research across resources, including users' local centralized...
Studies of the encoding sensory stimuli by brain often consider recorded neurons as a pool identical units. Here, we report divergence in stimulus-encoding properties between subpopulations cortical that are classified based on spike timing and waveform features. Neurons auditory cortex awake marmoset ( Callithrix jacchus ) encode temporal information with either stimulus-synchronized or nonsynchronized responses. When single-unit recordings using criteria-based an unsupervised...