A5036053988- Complement system in diseases
- Renal Diseases and Glomerulopathies
- Blood groups and transfusion
- Renal Transplantation Outcomes and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Genetic and Kidney Cyst Diseases
- Hemophilia Treatment and Research
- Phagocytosis and Immune Regulation
- Blood Coagulation and Thrombosis Mechanisms
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Adenosine and Purinergic Signaling
- Chronic Myeloid Leukemia Treatments
- Liver Disease and Transplantation
- Holomorphic and Operator Theory
University of Iowa
2017-2023
Renal Research Institute
2017-2023
Carver Bible College
2023
Iowa City Public Library
2023
The thrombotic microangiopathies (TMAs) and C3 glomerulopathies (C3Gs) include a spectrum of rare diseases such as atypical hemolytic uremic syndrome, thrombocytopenic purpura, C3GN, dense deposit disease, which share phenotypic similarities underlying genetic commonalities. Variants in several genes contribute to the pathogenesis these diseases, identification variants may inform diagnosis treatment affected patients. We have developed validated comprehensive panel that screens all exons...
IntroductionC3 Glomerulopathy (C3G) is an ultra-rare renal disease characterized by deposition of complement component C3 in the glomerular basement membrane. Rare and novel genetic variation genes autoantibodies to proteins are commonly identified C3G population thought drive underlying dysregulation that results damage; however, heterogeneity rarity make accurately defining characteristics difficult.MethodsHere we present a retrospective analysis Molecular Otolaryngology Renal Research...
IntroductionC3 Glomerulopathy (C3G) is an ultra-rare renal disease mediated by dysregulation of the alternative pathway (AP) complement system. Rare and novel genetic variation in genes autoantibodies to proteins are commonly identified C3G population thought drive dysregulation. Most C3 C5 nephritic factors that bind stabilize AP convertases, respectively. The rare heterogeneous nature makes understanding how these immunologic may influence progression difficult. We hypothesize systemic...