Stimuli-responsive bacterial cellulose-g-poly(acrylic acid) hydrogels were investigated for their potential use as an oral delivery system proteins. These synthesized using electron beam irradiation without any cross-linking agents, thereby eliminating toxic effects associated with cross-linkers. Bovine serum albumin (BSA), a model protein drug, was loaded into the hydrogels, and release profile in simulated gastrointestinal fluids investigated. Cumulative of less than 10% gastric fluid...

Various swelling drug delivery devices are promising materials for control because of their ability to swell and release entrapped therapeutics, in response physiological stimuli. Previously, many mathematical models have been developed predict the mechanism from a device. However, some these do not consider changes diffusion behaviour as device swells. Therefore, we used two-phase approach simplify model considering effect on coefficient. We began by defining moving boundary problem...

The decision-making trial and evaluation laboratory (DEMATEL) has been used to solve numerous multicriteria (MCDM) problems, where real numbers are utilised in defining linguistic variables. Although the DEMATEL shown its success solving many researchers have not fully understood how works on non-real-number Recent discovery of single-valued neutrosophic sets (SVNSs) can offer a new method three memberships SVNSs define experts’ judgment. This paper aims propose novel MCDM method, utilised....

Biomolecules have been widely investigated as potential therapeutics for various diseases. However their use is limited due to rapid degradation and poor cellular uptake in vitro vivo. To address this issue, we synthesized a new nano-carrier system comprising of cholic acid-polyethylenimine (CA-PEI) copolymer micelles, via carbodiimide-mediated coupling the efficient delivery small interfering ribonucleic acid (siRNA) bovine serum albumin (BSA) model protein. The mean particle size siRNA- or...

Hydrogel is known as a good drug delivery material. The hydrogel characteristic of swelling upon contact with fluid helps in delivering the controlled manner. However this phenomenon makes mathematical model more complicated. In study, an analytical solution discussed and tested order to illustrate release from logistically hydrogel. developed using advection-diffusion equation. Landau transformation used simplify release, separation variables method obtain equation for concentration result...

The magnetic field and Hall current effects have been considered on blood velocity concentration of low-density lipoprotein (LDL). It is important to observe those the flowing in a stenosed artery. analysis from obtained results may be useful some clinical procedures, such as MRI, where radiologists more information investigations before cardiac operations could done. In this study, uniform are applied Newtonian flow through an artery having cosine-shaped stenosis. governing equations...

This paper discusses the development and analytical solution of a mathematical model based on drug release system from swelling delivery device. The is represented by one-dimensional advection-diffusion equation with nonhomogeneous moving boundary condition. procedures consist three major steps. Firstly, application steady state method, which used to transform condition homogeneous Secondly, Landau transformation technique that gives significant impact in removing advection term transforming...

In this paper we present a state observer approach for the estimation of effective diffusion coefficients drug delivery device.In approach, construct estimators unknown characterizing thediffusion process release device using combination observers from area adaptive control andthe models developed recently by us. We show that constructed systems are asymptoticallystable and converge to exact coefficients. An algorithm is proposedto recursively compute estimatorsusing given time series...

The performance of a new beta in conjugate gradient method is generally measured on its CPU time and the number iterations using large scale problems without concerning accuracy solution attained. claimed to be best when less used comparison with other classical beta. However, gained compared exact function has never been tested as part measurement. Our previous research already proven that our perform well both speed used. Therefore, this research, we will accommodate alternative numerical...

This paper presents a numerical technique in three dimensions for estimating effective diffusion coefficients of drug release devices rotating and flow-through fluid systems. We first formulate the problems as equation systems with unknown coefficients. then develop based on nonlinear least-squares method finite volume discretization scheme 3D equations. Numerical experiments have been performed using experimental data results are presented to show that our methods give accurate diffusivity...

The government is committed in making Malaysia a regional hub for higher education by ensuring excellence service and quality. gap between men women regarding has been worldwide. Recently, the undergraduate enrolment science fields Malaysian public universities declining. factors which can attract students to enrol depend on many variables. This study analyses students' three categories of using ANOVA test Pearson Correlation Coefficient. second analyse gender factor Gender Parity Index...

Study on drug release from a moving boundary device has been quite popular among the researchers these days. Some research done pertaining to in small intestine. In this paper, we would like develop mathematical model for controlled swelling hydrogel For project, are considering and parameter of absorption We start by solving analytical solution hydrogel. derive advection-diffusion equation describe transport. Landau transformation is applied onto remove convective term solved using...

Oil is a highly demanded worldwide product as oil prices can have major economic and social impact. There are many factors affecting prices, but little known about which factor mostly influenced prices. To understand what caused the fluctuation of investigation leading up to identification must be constructed. Thus, this paper attempts explore that might contributed analyze them using fuzzy preference ranking organization method for enrichment evaluation (PROMETHEE) method. In particular,...

Drugs seem to diffuse in different manners a delivery device due the increment of pore size during swelling. However, diffusion parameter, D, is often assumed constant. In this work, new developed controlled drug release model with time-dependent parameter compared one- and two-phase models. The was obtained as an improvement previous constant piece-wise constants models are by solving advection–diffusion equation using Landau transformation method separation variables method. To test these...

In this work, we consider the second order nonlinear integro-differential Equation (IDEs) of Volterra-Fredholm type. One popular methods for solving Volterra or Fredholm type IDEs is method quadrature while problem consideration a linear problem. If are integral kernel complicated, then rule not most suitable; therefore, other types needed to develop. suitable and effective homotopy analysis (HAM) developed by Liao in 1992. To apply HAM, firstly reduced into (IEs) type; standard HAM was...

Small intestine is the main absorptive organ of orally consumed drugs in body. Hydrogel one materials that commonly used as a controlled drug release device able to deliver be absorbed small intestine. This material swells enable release, leading dynamic diffusivity. In this paper, we aimed simulate from swelling hydrogel considering diffusion coefficient one-compartmental system The considered single compartment where process takes place simultaneously with absorption and elimination...