A5050162788- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiovascular Function and Risk Factors
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Mast cells and histamine
- Parathyroid Disorders and Treatments
- Cardiac Valve Diseases and Treatments
- Health Promotion and Cardiovascular Prevention
- Pleural and Pulmonary Diseases
- Pneumothorax, Barotrauma, Emphysema
- Biotin and Related Studies
- COVID-19 and Mental Health
- Pulmonary Hypertension Research and Treatments
- COVID-19 and healthcare impacts
- Cardiomyopathy and Myosin Studies
- Congenital Heart Disease Studies
- Racial and Ethnic Identity Research
- Cardiovascular Health and Risk Factors
- Cardiac Health and Mental Health
- Renin-Angiotensin System Studies
- Industrial Vision Systems and Defect Detection
University of California, Davis
2021-2024
University of California Davis Medical Center
2023
University of California, Los Angeles
2019
UCLA Health
2018
New York Medical College
2016
Age-dependent alteration of the renin-angiotensin system (RAS) and generation angiotensin II (Ang II) are well documented. By contrast, RAS-independent Ang in aging its responses to exercise have not been explored. To this end, we examined effects chymase, a secretory serine protease, on angiotensin-converting enzyme (ACE)-independent conversion I II. We hypothesized that age-dependent cardiac formation is chymase dependent nature prevented by training. Experiments were conducted hearts...
Transthyretin amyloid cardiomyopathy (ATTR-CM) affects all cardiac chambers to cause left ventricular (LV) deformation as well atrial (LA) remodeling and functional impairment. We investigated the associations of LA volume index (LAVI):LV ejection fraction (LVEF) ratio with increased risk death, heart transplant, or LV assist device implantation (LVAD) in patients ATTR-CM.
Introduction Angiotensin II (Ang II) is a key effector peptide of the renin angiotensin system (RAS) and primarily known to be metabolized by converting enzyme 1 (ACE 1) from I I). More recently, chymase, an endopeptidase present in mast cells, has been reported play large role conversion Ang II. While ACE chymase are involved production I, another RAS related enzyme, 2 2), degradation. The cumulative effect 1, may ultimately determine levels tissues. Although adequate necessary for proper...