A5000755839- Building Energy and Comfort Optimization
- Urban Heat Island Mitigation
- Archaeological and Historical Studies
- Historical Art and Architecture Studies
- Environmental and Ecological Studies
- Historical Studies of Medieval Iberia
- Wind and Air Flow Studies
- Medieval Architecture and Archaeology
- Railway Systems and Energy Efficiency
- Noise Effects and Management
- Urbanism, Landscape, and Tourism Studies
- Structural Engineering and Vibration Analysis
- Conservation Techniques and Studies
- Transport and Economic Policies
- Maritime Ports and Logistics
- Historical and socio-economic studies of Spain and related regions
- Galician and Iberian cultural studies
- Building materials and conservation
- Advanced Breast Cancer Therapies
- Prostate Cancer Treatment and Research
- HER2/EGFR in Cancer Research
- Architecture, Art, Education
- Cancer Genomics and Diagnostics
- Architecture and Art History Studies
- Computational Drug Discovery Methods
Universidad de Sevilla
2016-2025
Natera (United States)
2022-2025
Epic Sciences (United States)
2019
Universidad Nacional Autónoma de México
2013-2018
Methodist Hospital
2013-2014
The University of Texas at Austin
2013
Cornell University
2013
Children's Cancer Center
2013
Baylor College of Medicine
2013
Houston Methodist
2013
Abstract Optimal timing and dosing of adjuvant cyclin-dependent kinase (CDK) 4/6 inhibitor in early breast cancer is controversial. This prospective phase II clinical trial investigated tolerability safety two ribociclib schedules. Patients with stage I–III hormone receptor-positive (HR+)/HER2– on endocrine therapy (ET) were randomized to schedules: 400 mg continuous vs 600 intermittent, initiation (prior ET < 2 years) delayed ≥ setting. Primary objective was evaluate intermittent...
There is an impending need to retrofit the existing social housing stock improve thermal comfort and reduce energy demand. This research proposes calibrated building models assess of southern Spain (Mediterranean area). Several strategies are optimised using a genetic algorithm obtain best solutions, considering three objectives: annual overheating hours (%), undercooling (%) investment costs (€/m2). Results shown for four different climatic areas in Spain. study finds that it possible...
When proposing the most suitable strategies for retrofitting residential stock it is essential to consider energy vulnerability, current state of stock, users' economic capacity and climate. This work analyses vulnerability on regional neighbourhood scale, applied social housing in southern Spain. Three key indicators are assessed through extensive public databases validated parametric simulation models: 1) buildings performance, based simulated indoor thermal comfort; 2) socio-economic...
This work evaluates the potential for reduction of energy demand in residential buildings by acting on exterior envelope, both newly constructed and retrofitting existing stock. It focuses analysing social housing Mediterranean areas quantifying scope that application different envelope design strategies, with purpose prioritizing their based efficiency. The analyses quantifications were made means generation models TRNSYS tool simple or combined solutions, identifying possible potentials...
En los edificios de viviendas españoles podemos estimar que la mitad del consumo energético se debe a sistemas calefacción y refrigeración. general, resulta aconsejable invertir en proyectos rehabilitación para limitar su demanda energética, sin embargo, aunque las intervenciones energéticas puedan suponer un significativo potencial ahorro energía, habría manifestar muchas situaciones, especialmente el área sur, no siempre será así, con desviaciones importantes comportamientos energéticos...
A new type of signaling network element, called cancer bridges (CSB), has been shown to have the potential for systematic and fast-tracked drug repositioning. On basis CSBs, we developed a computational model derive specific downstream pathways that reveal previously unknown target-disease connections mechanisms subtypes. The enables us reposition drugs based on available patient gene expression data. We applied this repurpose known or shelved brain, lung, bone metastases breast with...
Heat waves are expected to increase the use of air conditioning (AC), deriving in higher energy consumption. This research aims determine whether thermal insulation is an effective retrofit strategy for tackling overheating. Four occupied dwellings southern Spain were monitored: two houses built prior any criteria and with current standards. Thermal comfort assessed considering adaptive models user patterns operation AC natural ventilation. Results show that a high level combined proper...
Quantifying and rating energy flexibility in existing buildings will become increasingly important as building services electrified. Flexibility ratings based on design specifications have shown potential to complement performance certificates enable the comparison between buildings. However, relying physical models standard boundary conditions could lead a 'flexibility gap': difference predicted actual flexibility. This article investigates incorporation of monitored data into design-based...
The current European energy policies have an influence on the need to rehabilitate housing stock in order meet objectives of Union. Most this was built without any type regulation adverse technical and economic conditions thus is now energetically obsolete. major rehabilitation effort required must be approached through actions based previous quantitative knowledge existing buildings guarantee efficiency energy-retrofitted solutions. This assessment can carried out monitoring dwellings...
According to the IPCC Climate Change projections by 2050 temperatures in southern Spain will have increased noticeably during summer. Housing—in its current form—will not be able provide a suitable response this new climate scenario, and turn prompt an increase cooling energy consumption series of problems relating health comfort. The Design Builder simulation tool was used quantify impact future scenario on demand, as well effect under free-running conditions indoor temperature. Different...
Due to 2030 and 2050 targets of the latest international standards, energetically retrofitting existing building sector requires special attention. Prior proposal retrofit strategies, it is necessary analyse current energy performance stock. Although simulation tools provide accurate results at level, individual assessments large-scale stock lead extensive data collection huge computational resources. This paper assesses one most representative typologies in social housing southern Spain,...
This article contains an overall analysis of the results obtained by four highest scoring teams in Solar Decathlon Latin America and Caribbean 2015 collegiate sustainable habitat competition. Considering that prototypes developed were based on energy self-sufficiency when operational, it was considered necessary to propose this degree suitability each these models their different performances from perspective comfort conditions. It observed design did not manage properly adjust relationship...
Retrofitting the existing building stock is widely accepted as a crucial factor to reaching 2030 and 2050 climate energy targets, given that sector among top three most dominant consumers. This paper presents bottom-up study which uses calibrated parameterized models (building archetypes), while also incorporating information from large database. The thermal performance of social housing southern Spain assessed through dynamic simulation under present future change scenarios. Subsequently,...
The aim of this paper is to broaden understanding the social housing prototype that students and researchers at University Seville developed in response tropical climate conditions achieve maximum level hygrothermal comfort through use passive retrofit strategies. This prototype, known as Aura 1.0, was presented Solar Decathlon competition where inside were monitored over a ten-day period. Nevertheless, monitoring period environmental so reduced, research assess behaviour for full year,...