A5101576350- Myasthenia Gravis and Thymoma
- Peripheral Neuropathies and Disorders
- Monoclonal and Polyclonal Antibodies Research
- Parkinson's Disease and Spinal Disorders
- Ion channel regulation and function
- Pituitary Gland Disorders and Treatments
- Glycogen Storage Diseases and Myoclonus
- Receptor Mechanisms and Signaling
- Vaccine Coverage and Hesitancy
- Cardiac electrophysiology and arrhythmias
- Neurogenetic and Muscular Disorders Research
- T-cell and B-cell Immunology
- Muscle and Compartmental Disorders
- Inflammatory Myopathies and Dermatomyositis
- Immunotherapy and Immune Responses
- Toxin Mechanisms and Immunotoxins
- Neurological disorders and treatments
- Thyroid and Parathyroid Surgery
- Antifungal resistance and susceptibility
- Hereditary Neurological Disorders
- Genetic Neurodegenerative Diseases
- Neuroscience and Neural Engineering
- Mitochondrial Function and Pathology
- Cardiomyopathy and Myosin Studies
- Galectins and Cancer Biology
Florida International University
2023-2024
National Institute of Neurological Disorders and Stroke
1996-2001
Columbia University
1983-2001
National Institutes of Health
1999-2001
NewYork–Presbyterian Hospital
1976-2000
The University of Texas Southwestern Medical Center
2000
Beaumont Hospital, Royal Oak
2000
Myasthenia Gravis Foundation of America
2000
University of California, Los Angeles
2000
Duke Medical Center
2000
The mitochondrial myopathies typically affect many organ systems and are associated with mutations in DNA (mtDNA) that maternally inherited. However, there is also a sporadic form of myopathy which exercise intolerance the predominant symptom. We studied biochemical molecular characteristics this myopathy.
PERIPHERAL neuropathy has been associated with plasma-cell dyscrasia, 1 but it is not known whether the monoclonal immunoglobulins react peripheral-nerve antigens. We report on a patient peripheral an IgMk protein, in whom pathological and immunological studies indicated that antibody was directed against myelin, as shown by complement fixation immunoabsorption.Case ReportThe 45-year-old man admitted for evaluation of slowly progressive sensory-motor 11 years' duration. On examination there...
Andersen's syndrome is a clinically distinct form of potassium-sensitive periodic paralysis associated with cardiac dysrhythmias. The subtle nature the and dysmorphic features may delay recognition this its potentially lethal genetic defect in not genetically linked to other forms probably from long QT locus.
Abstract A retrospective study of 108 patients with myasthenia gravis who had solely ocular symptoms and signs at onset was carried out to identify factors influencing prognosis. Increasing duration pure associated a decreasing risk late generalized symptoms; only 9 (15%) the observed generalizations occurred after more than 2 years symptoms. age greater respiratory crisis or death caused by myasthenia, whereas younger chance benign outcome. Neither systemic curare tests nor responses...
Of 221 patients with myasthenia gravis, 18.5% had no detectable antibodies to acetylcholine receptor. Seven of 14 (50%) only ocular symptoms for more than 2 years were seronegative, and 25 145 (17%) generalized seronegative. The clinical characteristics seronegative did not differ from high antibody titers. No patient a thymoma, but that difference reach statistical significance. Lack serum preclude favorable response thymectomy or plasmapheresis.
In some cases of polyneuropathy and plasma cell dyscrasia, the monclonal antibodies react with human peripheral nerve myelin. To identify myelin antigens involved, we separated proteins central by polyacrylamide gel electrophoresis, transferred onto nitrocellulose sheets, used an immunoenzymatic technique to detect reactive antigens. Serum IgM but not IgG from three patients neuropathy complement-fixing anti-human paraproteins immunostained a protein approximately 100,000 daltons in or...
trans-3,3'-Bis[alpha-(trimethylammonio)methyl]azobenzene bromide (BisQ) is a potent agonist of the acetylcholine receptor (AcChoR) Electrophorus electricus. BisQ highly constrained, suggesting that its structure complementary to combining site AcChoR when latter in activated state. Antibodies produced rabbits conjugate bovine serum albumin and derivative mimicked binding characteristics with respect order variety agonists preferred recognition decamethonium ion (an agonist) over...
Abstract Comparisons of several types immunologic reactivity were made in thymic cells from six patients with myasthenia gravis and hyperplasia, four thymoma age-matched control cardiac-surgery patients. In mixed leukocyte reactions, the subjects hyperplasia capable stimulating autologous peripheral blood lymphocytes. Such was not seen thymocyte-blood lymphocyte mixtures other two groups. There an increased number B thymic-cell populations myasthenic as compared to that group, carrying...
We report the first isolation of influenza virus from muscle in a man with myoglobinuria and acute polymyositis. Influenza was isolated cultures Madin Darby bovine kidney primary rhesus monkey cells inoculated homogenates presence trypsin; identified by neutralization hemagglutination inhibition studies using B/Lee antiserum. Viral plaque assay performed canine cells. antigen also detected specific immunofluorescence muscle, myxovirus-like particles were seen subsarcolemmal vacuoles...
Myoglobinuria was proved in four patients coma after drug ingestion or injection and suspected others because of the very high serum enzyme concentrations, including creatine phosphokinase, renal insufficiency. The variety drugs used suggests that this is not a direct effect specific but due to several effects coma. Pressure upon dependent muscles immobile individuals probably primarily responsible, ischemia, anoxia, hypotension, hypothermia, acidosis contribute. In five there residual...
Myoglobinuria may follow extreme muscular exertion or disorders that cause muscle necrosis. Dystonia has not been implicated previously. We studied an 8-year-old boy of non-Jewish, Mexican-American descent with autosomal-dominant dystonia musculorum deformans who developed rapidly progressive and severe generalized dystonia, hyperpyrexia, myoglobinuria, renal failure. Curarization was required. Transient improvement achieved tetrabenazine baclofen, but bilateral thalamotomy then performed....
Serum from patients with peripheral neuropathies was tested for antiperipheral nerve myelin antibodies by complement fixation. Antibody activity detected in 5 of 20 acute or chronic remitting polyneuritis and 4 polyneuropathy paraproteinemia but not other types neuropathy, neurologic disease, immunologic disease. In three IgM paraproteinemia, the complement-fixing resided fraction; one patient inflammatory polyneuritis, antibody IgG fraction. polyneuropathies, titers did always correlate...
Autosomal dominant motor system degeneration (ADMSD) is a hereditary ataxia that has been reported previously only in Portuguese families from the Azores Islands. Cerebellar ataxia, pyramidal and extrapyramidal signs, amyotrophy, dystonia, abnormal eye movements, prominent eyes are variably present. Four members of family had cerebellar dystonic posturing, variety resulting lid retraction. Eight other similar disease. The combination ADMSD. here may be first example ADMSD non-Portuguese family.
Acetylcholine receptors (AChR), purified from electric eel and Torpedo by affinity chromatography using a synthetic quaternary ammonium ligand, bound 10 nmole alpha-bungarotoxin (alpha-BuTx) per mg of protein demonstrated common subunit. Rabbits, immunized with either or Torpedo/AChR, developed flaccid paralysis barely altered anticholinesterases died 48 hours after the first sign paralysis. In paralyzed animals, repetitive stimulation at low rates induced 50% to 90% decrement evoked...
Journal Article FAMILIAL NEURALGIC AMYOTROPHY: REPORT OF THREE FAMILIES WITH REVIEW THE LITERATURE Get access LEONARD R. GEIGER, GEIGER Search for other works by this author on: Oxford Academic PubMed Google Scholar ELLIOTT L. MANCALL, MANCALL AUDREY S. PENN, PENN SAMUEL H. TUCKER Department of Neurology, University PennsylvaniaPhiladelphia, Pennsylvania 19104 USA Brain, Volume 97, Issue 1, 1974, Pages 87–102, https://doi.org/10.1093/brain/97.1.87 Published: 01 January 1974 history Received:...
Autoimmune diseases, including myasthenia gravis, occur in patients treated with D-penicillamine. Because D-penicillamine might induce autoantibodies by the mechanism of antigenic alteration, we studied reaction purified acetylcholine receptor from <i>Torpedo californica</i>. We found that brief exposure to resulted its covalent attachment two subunits, alpha (40,000 daltons) and gamma (59,000 Daltons), presumably reduction formation mixed disulfides. Furthermore, treatment a dramatic...