A5002533788- Bioinformatics and Genomic Networks
- Alzheimer's disease research and treatments
- Genetics and Neurodevelopmental Disorders
- Health, Environment, Cognitive Aging
- Genetic Associations and Epidemiology
- Genetic Syndromes and Imprinting
- Air Quality and Health Impacts
- Nutritional Studies and Diet
- Genomic variations and chromosomal abnormalities
- Biotin and Related Studies
- Epigenetics and DNA Methylation
- Metabolomics and Mass Spectrometry Studies
- Computational Drug Discovery Methods
- Thermal Radiation and Cooling Technologies
- Attention Deficit Hyperactivity Disorder
- Genetic Mapping and Diversity in Plants and Animals
- Advanced Thermoelectric Materials and Devices
- Dementia and Cognitive Impairment Research
- Quantum Dots Synthesis And Properties
- Bipolar Disorder and Treatment
University of California, Davis
2025
Emory University
2022-2023
Chongqing University
2023
The biological processes that are disrupted in the Alzheimer's disease (AD) brain remain incompletely understood. In this study, we analyzed proteomes of more than 1,000 tissues to reveal new AD-related protein co-expression modules were highly preserved across cohorts and regions. Nearly half modules, including significantly altered AD, not observed RNA networks from same regions, highlighting proteopathic nature AD. Two such AD-associated unique proteomic network included a module related...
Several common psychiatric and neurodegenerative diseases share epidemiologic risk; however, whether they pathophysiology is unclear the focus of our investigation. Using 25 GWAS results LD score regression, we find eight significant genetic correlations between diseases. We integrate with human brain transcriptomes (n = 888) proteomes 722) to identify cis- trans- transcripts proteins that are consistent a pleiotropic or causal role in each disease, referred as for brevity. Within disease...
Abstract Most complex human traits differ by sex, but we have limited insight into the underlying mechanisms. Here, investigated influence of biological sex on protein expression and its genetic regulation in 1,277 brain proteomes. We found that 13.2% (1,354) proteins had sex-differentiated abundance 1.5% (150) sex-biased quantitative trait loci (sb-pQTLs). Among genes with expression, 67% concordance between transcript levels; however, effects were more evident at level. Considering 24...
Alzheimer’s disease (AD) is a neurodegenerative with heterogenous pathophysiological changes that develop years before the onset of clinical symptoms. These preclinical have generated considerable interest in identifying markers for mechanisms linked to AD and AD-related disorders (ADRD). On basis our prior work integrating cerebrospinal fluid (CSF) brain proteome networks, we developed reliable high-throughput mass spectrometry–selected reaction monitoring assay targets 48 key proteins...
Abstract INTRODUCTION Cerebrospinal fluid (CSF) biomarkers of Alzheimer’s disease (AD) are reliable predictors future AD risk. We investigated whether pre-clinical changes in CSF reflected blood DNA methylation (DNAm) levels cognitively normal participants. METHODS profiled blood-based DNAm with the EPIC array participants without a diagnosis cognitive impairment Emory Healthy Brain Study (EHBS; N=495) and ADNI (N=122). Their Aβ42, tTau, pTau were quantified using Elecsys immunoassays....
Fine particulate matter (PM 2.5 ) is a known risk factor for Alzheimer's disease (AD), with emerging evidence linking PM exposure to cerebrospinal fluid (CSF) biomarkers in pre-clinical stages. However, the role of DNA methylation (DNAm) as potential mediator this relationship among cognitively normal individuals remains largely unexplored. In 535 individuals, we assessed genome-wide blood DNAm, CSF Aβ 42 concentrations, and residential year preceding collection. Multi-stage comprehensive...
Abstract INTRODUCTION Sex differences exist in Alzheimer's disease (AD), but the underlying mechanisms remain unclear. METHODS We examined brain proteomes profiled from dorsolateral prefrontal cortex of 770 donors (66.2% female). RESULTS Proteome‐wide differential expression analysis males and females jointly identified many significant proteins for AD dementia ( n = 1228), amyloid beta 1183), tangles 1309), global cognitive trajectory 2325) at a false discovery rate <0.05. Sex‐stratified...
Abstract Background Three lines of epidemiologic evidence link several psychiatric disorders to ADRD. First, experiencing schizophrenia or a mood/anxiety disorder in early/mid‐adulthood increases the risk developing dementia by 6‐folds. Second, approximately 80% ADRD patients experience neuropsychiatric symptoms (NPS), including depression, apathy, anxiety, irritability, agitation, delusions, and hallucinations. Third, these NPS overlap with disorders. Given observations, this study focuses...