A5049414850- Chemical Synthesis and Analysis
- RNA and protein synthesis mechanisms
- Computational Drug Discovery Methods
- S100 Proteins and Annexins
- Cell Image Analysis Techniques
- Click Chemistry and Applications
- Monoclonal and Polyclonal Antibodies Research
- Viral Infectious Diseases and Gene Expression in Insects
- Protein purification and stability
- Pancreatic function and diabetes
University of Copenhagen
2022-2024
Many peptide hormones form an α-helix on binding their receptors
Abstract Many peptide hormones form an alpha-helix upon binding their receptors 1–4 , and sensitive detection methods for them could contribute to better clinical management. De novo protein design can now generate binders with high affinity specificity structured proteins 5,6 . However, the of interactions between short helical peptides is unmet challenge. Here, we describe parametric generation deep learning-based designing address this We show that RF diffusion generative model, picomolar...
Interactions between proteins and α-helical peptides have been the focus of drug discovery campaigns. However, large interfaces formed multiple turns an α-helix a binding protein represent significant challenge to inhibitor discovery. Modified featuring helix-stabilizing macrocycles shown promise as inhibitors these interactions. Here, we tested ability N-terminal side-chain thioether-cyclized inhibit Mcl-1, by screening trillion-scale library. The enriched were lariats small,...
Interactions between proteins and α-helical peptides are abundant in the human cell. Many of these interactions linked to disease have been focus drug discovery campaigns. However, large interfaces formed multiple turns α-helix a binding protein represent significant challenge inhibitor discovery. Modified featuring helix-stabilizing macrocycles shown promise as inhibitors interactions. Here, we tested ability N-terminal side-chain thioether-cyclized inhibit Mcl-1, by screening...