A5031838340- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Diet and metabolism studies
- Blood Pressure and Hypertension Studies
- Hemoglobinopathies and Related Disorders
- Obstructive Sleep Apnea Research
- Parathyroid Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- Complement system in diseases
- Erythropoietin and Anemia Treatment
- Magnesium in Health and Disease
- Diabetes Treatment and Management
- Muscle and Compartmental Disorders
- Gut microbiota and health
- Probiotics and Fermented Foods
- Nutrition and Health in Aging
- Renal and Vascular Pathologies
- Cardiovascular and Diving-Related Complications
- Adenosine and Purinergic Signaling
- Bariatric Surgery and Outcomes
- Nosocomial Infections in ICU
- Iron Metabolism and Disorders
- Tuberculosis Research and Epidemiology
- Artificial Intelligence in Healthcare
- Antimicrobial Peptides and Activities
I-Shou University
2014-2025
E-Da Hospital
2014-2025
Institute of Biomedical Sciences, Academia Sinica
2023
National Yang Ming Chiao Tung University
2022
Weatherford College
2022
Directorate-General for Interpretation
2015
National Cheng Kung University Hospital
2015
Fresenius Medical Care (Germany)
2003-2006
Sleep apnea (SA) is characterized by during sleep and associated with cardiovascular diseases an increase in all-cause mortality. Chronic kidney disease (CKD) a global health problem that has placed substantial burden on healthcare resources. However, the relationship between SA incidence of CKD not clear. This study aimed to determine whether independent risk factor for development CKD.Retrospective cohort study.National Health Insurance Research Database (NHIRD) Taiwan.A total 4,674 adult...
Parkinson's disease (PD) is a neurodegenerative characterized by motor deficits and marked neuroinflammation in various brain regions. The pathophysiology of PD complex mounting evidence has suggested an association with the dysregulation microRNAs (miRNAs) gut dysbiosis. Using rotenone-induced mouse model, we observed that administration Lactobacillus plantarum PS128 (PS128) significantly improved PD-like mice, accompanied increased level dopamine, reduced dopaminergic neuron loss,...
Abstract Background Inhibiting the development and progression of diabetic kidney disease (DKD) is an important issue, but renoprotective effect metformin still controversial. Objective To assess in patients with type 2 diabetes. Methods This retrospective observational multicenter cohort study included 316 693 diabetes from 7 hospitals. After matching for age, gender, medical year, baseline estimated glomerular filtration rate (eGFR), urine protein (dipstick), glycated hemoglobin (HbA1c)...
Abstract Lactobacillus plantarum PS128 has been reported as a psychobiotic to improve mental health through the gut–brain axis in experimental animal models. To explore its mechanism of action gut, this study aimed analyze effects L. ingestion on naïve and loperamide (Lop)-induced constipation mice. We found that, two mouse models, weight, number, water content feces group were higher than those vehicle control group. Histological observation revealed that increased level colonic mucins...
Lacticaseibacillus paracasei strain PS23 (PS23) exhibits some probiotic properties. In this study, a genomic analysis of revealed no genes related to virulence or antibiotic resistance. Moreover, ornithine decarboxylase activity was not detected in vitro. addition, sensitive the tested antibiotics. Genotoxicity tests for including Ames test and chromosomal aberrations vitro using Chinese hamster ovary cells micronuclei immature erythrocytes ICR mice were all negative. following 28-day study...
Peritoneal dialysis (PD) is one type of renal replacement therapy, but potential peritoneal damage and gastrointestinal (GI) tract adverse effects during long-term exposure to bio-incompatible dialysate remain a concern. Although GI disease frequently occurs in patients, whether the risk diseases differs among PD hemodialysis (HD) or non-uremic groups still uncertain. In this retrospective cohort study, data were obtained from National Health Insurance Research Database, which includes...
Background: Recent evidence supports the protective role of metformin on kidney function in patients with type 2 diabetes mellitus. However, its potential to prevent new-onset chronic disease (CKD) mellitus normal renal remains unclear. Therefore, this study aimed investigate whether could development CKD such patients. Methods: This retrospective, observational, multicenter cohort included 316,693 After matching using inverse probability treatment weighting, 9109 users and 1221 nonusers...
Some probiotics have been shown to alleviate age-related muscle atrophy via the gut-muscle axis. The aim of this study was investigate effects live or heat-killed Lactobacillus paracasei PS23 (PS23) on health in D-galactose-induced aging mice. Administration D-galactose significantly reduced strength, size, and levels phosphorylated Akt These were ameliorated by both supplementation. Ghrelin is a multifaceted gut hormone with ability improve atrophy. ghrelin serum stomach mice also could be...
The Taiwanese government launched a universal pay-for-performance (P4P) program in 2006 to promote multidisciplinary care for patients with stage 3b-5 chronic kidney disease (CKD). This study aimed understand the enrollments, processes, and outcomes of P4P between 2010 2018.We conducted population-based using Taiwan National Health Insurance Research Data. We divided incident dialysis population into joining not groups based on whether had joined pre-ESRD before or not. Trends medications...
Haemolytic-uremic syndrome (HUS) is a severe, life-threatening disease with symptoms such as haemolytic anaemia, renal failure, and low platelet count. Possible aetiology includes bacterial infections, medication, post-hematopoietic cell transplantation, pregnancy, autoimmune disease, acquired immunodeficiency syndrome.We report the case of 21-year-old healthy man who developed acute failure caused by HUS. Typical HUS combined severe uraemia following large local reaction after suspected...
Abstract The association between serious falls and dialysis modality [hemodialysis (HD) peritoneal (PD)] is unclear. A nationwide population-based retrospective cohort study with 127,823 end-stage renal disease patients aged over 18 years was conducted the unmatched of 101,304 HD 7,584 PD retrieved from Taiwan’s National Health Insurance Research Database during 2000–2013. total matched at 1:1 ratio by propensity score were enrolled to study. Serious defined diagnostic codes, E code, image...
Patients with end-stage renal disease (ESRD) are at a higher mortality risk compared the general population. Previous studies have described relationship between and patients ESRD, but data on standardized ratio (SMR) corresponding to different causes of death in undergoing hemodialysis (HD) peritoneal dialysis (PD) limited. This study was designed as nationwide population-based retrospective cohort study. Incident January 2000 December 2015 Taiwan were included. Using acquired from Death...
Background . Peritoneal dialysis (PD) can induce fibrosis and functional alterations in PD patients’ peritoneal membranes, due to long-term unphysiological dialysate exposure, partially occurring via triggering of epithelial-to-mesenchymal transition (EMT) mesothelial cells (MCs). Vitamin D ameliorate these negative effects; however, the mechanism remains unexplored. Therefore, we investigated its possible links MCs EMT inhibition. Methods was established Sprague-Dawley rats by chlorhexidine...
Abstract Background Peritoneal dialysis (PD) therapy is known to induce morphological and functional changes in the peritoneal membrane. Long-term exposure conventional bio-incompatible dialysate peritonitis main etiology of inflammation. Consequently, membrane undergoes structural changes, including angiogenesis, fibrosis, hyalinizing vasculopathy, which ultimately results technique failure. The epithelial-to-mesenchymal transition (EMT) mesothelial cells (MCs) plays an important role...
Bacterial colonization patterns in daily chlorhexidine care at the exit site peritoneal dialysis (PD) patients were not known. We performed a prospective, randomized controlled trial enrolling 89 PD patients. After stratification by initial Staphylococcus aureus (SA) carrier status, randomly assigned to receive 4% (intervention group) or normal saline (control site. Monthly, we cultured bacteria from and nasal swabs for 1 year. The SA rates 6 12 months significantly lower intervention group...
Purpose: Vitamin D3 is useful for the treatment of peritoneal dialysis (PD)-related damage, but its side effects, such as hypercalcemia and vascular calcification, limit applicability. Thus, we developed vitamin D-loaded magnetic nanoparticles (MNPs) determined their therapeutic efficacy effects in vivo. Materials Methods: Alginate-modified MNPs were combined with 1α, 25 (OH) 2 D 3 to generate nanoparticles. The particles conjugated an antibody against peritoneum-glycoprotein M6A (GPM6A)....
The Clinical Implication of Vitamin D Nanomedicine for Peritoneal Dialysis-Related Damage Yi-Che Lee,1–3 Chih-Ting Huang,4 Fong-Yu Cheng,5 Shih-Yuan Hung,3,6 Tsun-Mei Lin,7 Yen-Chang Tsai,4 Chih-I Chen,8 Hao-Kuang Wang,9 Chi-Wei Lin,10 Hung-Hsiang Liou,11 Min-Yu Chang,3 Hsi-Hao Wang,3 Yuan-Yow Chiou4,12 1Division Nephrology, Department Internal Medicine, E-DA Dachang Hospital/ I-Shou University, Kaohsiung, Taiwan; 2School College Medicine; 3Division 4Institute National Cheng Kung Tainan,...
Peritoneal dialysis (PD) is a renal replacement therapy. One concern whether patients on PD have higher risk of sleep apnea (SA) due to intra-abdominal pressure increase and worsened ultrafiltration capacity. Despite this concern, date, the SA differs between PD, hemodialysis (HD), groups without uremia still uncertain.In retrospective cohort study, data were obtained from National Health Insurance Research Database Taiwan. This database enrolled almost all in country. A total 7,645 incident...
Abstract A mild decrease of ADAMTS13 (a disintegrin and metalloprotease with thrombospodin type 1 motif 13) could attribute to stroke coronary heart disease in general population. However, the role hemodialysis (HD) patients remains be explored. This cross-sectional observational cohort study enrolled 98 chronic HD 100 normal subjects aims compare activity between subjects, discover on newly developed cardiovascular events for a 2-year follow-up. Our had significantly lower than 41.0 ± 22.8%...
<b><i>Background:</i></b> High serum cystatin C (CysC) has been associated with clinical risks independently of the glomerular filtration rate (GFR). This study aims to investigate predictive power CysC in patients a negligible GFR. <b><i>Methods:</i></b> Patients on chronic hemodialysis or peritoneal dialysis were enrolled for measurement levels and followed up one year. A daily urine amount <100 ml was considered residual renal function...
BACKGROUND:This study from a single center in Taiwan aimed to evaluate the impact of remote patient monitoring (RPM) using Sharesource connectivity platform on adherence automated peritoneal dialysis (APD) 51 patients. MATERIAL AND METHODS:We analyzed data patients with end-stage renal disease (ESRD) under APD. They were treated traditional APD machine HomeChoice (phase 1), changed new Claria for 12 weeks 2), then connected another 3), and followed up 1 year. The non-adherence rate was...
Abstract In end-stage renal disease (ESRD) patients receiving dialysis, anemia is common and related to a higher mortality rate. Erythropoietin (EPO) resistance iron refractory require red blood cell transfusions. Myelodysplastic syndrome (MDS) with hematopoietic dysplasia. There are limited reports regarding ESRD MDS. We aim assess whether, for patients, undergoing dialysis predictive factor of MDS by analyzing data from the Taiwan National Health Insurance Research Database. enrolled...