About
Contact & Profiles
A5103284511
Research Areas
- Complement system in diseases
- Atherosclerosis and Cardiovascular Diseases
- Renal Diseases and Glomerulopathies
GlaxoSmithKline (United Kingdom)
2021
While serum-circulating complement destroys invading pathogens, intracellularly active complement, termed the “complosome,” functions as a vital orchestrator of cell-metabolic events underlying T cell effector responses. Whether intracellular is also nonredundant for activity myeloid immune cells currently unknown. Here, we show that monocytes and macrophages constitutively express component (C) 5 generate autocrine C5a via formation an C5 convertase. Cholesterol crystal sensing by induced...
10.1126/sciimmunol.abf2489
article
EN
Science Immunology
2021-12-21
Coming Soon ...