Olivia Marshall

ORCID: 0000-0003-3503-0413
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About
Contact & Profiles
Research Areas
  • Complement system in diseases
  • Atherosclerosis and Cardiovascular Diseases
  • Renal Diseases and Glomerulopathies

GlaxoSmithKline (United Kingdom)
2021

While serum-circulating complement destroys invading pathogens, intracellularly active complement, termed the “complosome,” functions as a vital orchestrator of cell-metabolic events underlying T cell effector responses. Whether intracellular is also nonredundant for activity myeloid immune cells currently unknown. Here, we show that monocytes and macrophages constitutively express component (C) 5 generate autocrine C5a via formation an C5 convertase. Cholesterol crystal sensing by induced...

10.1126/sciimmunol.abf2489 article EN Science Immunology 2021-12-21
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