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Sai Nelanuthala

ORCID: 0000-0003-3517-0328
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Contact & Profiles
A5061222796
Research Areas
  • Acute Myeloid Leukemia Research
  • Cancer-related molecular mechanisms research
  • Immune Cell Function and Interaction
  • Cancer-related gene regulation
  • Epigenetics and DNA Methylation
  • Hematopoietic Stem Cell Transplantation
  • Myeloproliferative Neoplasms: Diagnosis and Treatment

Indiana University School of Medicine
 2018-2020

Indiana University – Purdue University Indianapolis
 2018-2020

 Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis
OPENALEX - Publications 
Zhigang Cai Jonathan J. Kotzin Baskar Ramdas Sisi Chen Sai Nelanuthala and 10 more Lakshmi Reddy Palam Ruchi Pandey Raghuveer Singh Mali Yan Liu Mark R. Kelley George E. Sandusky Morvarid Mohseni Adam Williams Jorge Henao-Mejía Reuben Kapur

10.1016/j.stem.2018.10.013 article EN publisher-specific-oa Cell stem cell 2018-12-01
 Hyperglycemia cooperates with Tet2 heterozygosity to induce leukemia driven by proinflammatory cytokine–induced lncRNA Morrbid
OPENALEX - Publications 
Zhigang Cai Xiaoyu Lu Chi Zhang Sai Nelanuthala Fabiola Aguilera and 9 more Abigail Hadley Baskar Ramdas Fang Fang Kenneth P. Nephew Jonathan J. Kotzin Adam Williams Jorge Henao-Mejía Laura S. Haneline Reuben Kapur

Diabetes mellitus (DM) is a risk factor for cancer. The role of DM-induced hyperglycemic (HG) stress in blood cancer poorly understood. Epidemiologic studies show that individuals with DM are more likely to have higher rate mutations genes found pre-leukemic hematopoietic stem and progenitor cells (pre-LHSPCs) including TET2. TET2-mutant pre-LHSPCs require additional hits evolve into full-blown leukemia and/or an aggressive myeloproliferative neoplasm (MPN). Intrinsic been shown cooperate...

10.1172/jci140707 article EN Journal of Clinical Investigation 2020-10-22
 Downregulation of Morrbid in Tet2-Deficient Preleukemic Cells Overcomes Resistance to Inflammatory Stress and Mitigates Clonal Hematopoiesis
OPENALEX - Publications 
Zhigang Cai Jonathan J. Kotzin Baskar Ramdas Sisi Chen Sai Nelanuthala and 10 more Lakshmi Reddy Palam Ruchi Pandey Raghuveer Singh Mali Yan Liu Mark R. Kelley George E. Sandusky Morvarid Mohseni Adam Williams Jorge Henao-Mejía Reuben Kapur

10.1182/blood-2018-99-116703 article EN Blood 2018-11-29
 Hyperglycemia Cooperates with Tet2 Heterozygosity to Induce Leukemia Driven By Pro-Inflammatory Cytokine Induced Lncrna Morrbid
OPENALEX - Publications 
Zhigang Cai Reuben Kapur Xiaoyu Lu Chi Zhang Sai Nelanuthala and 7 more Jonathan J. Kotzin Adam Williams Jorge Henao-Mejía Fabiola Aguilera Abigail Hadley Fang Fang Kenneth P. Nephew

10.1182/blood-2020-141335 article EN Blood 2020-11-04
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