A5010552915- Genetics, Aging, and Longevity in Model Organisms
- Neuroendocrine regulation and behavior
- Physiological and biochemical adaptations
- Circadian rhythm and melatonin
KU Leuven
2023-2024
Peptides and protein hormones form the largest group of secreted signals that mediate intercellular communication are central regulators physiology behavior in all animals. Phylogenetic analyses biochemical identifications peptide-receptor systems reveal a broad evolutionary conservation these signaling at molecular level. Substantial progress has been made recent years on characterizing physiological putative ancestral roles many peptide through comparative studies invertebrate models....
In vertebrates, thyrostimulin is a highly conserved glycoprotein hormone that, besides thyroid stimulating (TSH), potent ligand of the TSH receptor. Thyrostimulin considered most ancestral and orthologs its subunits, GPA2 GPB5, are widely across vertebrate invertebrate animals. Unlike TSH, however, functions neuroendocrine system remain largely unexplored. Here, we identify functional thyrostimulin-like signaling in Caenorhabditis elegans . We show that together with thyrotropin-releasing...
Abstract In vertebrates, thyrostimulin is a highly conserved glycoprotein hormone that, besides thyroid stimulating (TSH), potent ligand of the TSH receptor. Thyrostimulin considered most ancestral and orthologs its subunits, GPA2 GPB5, are widely across vertebrate invertebrate animals. Unlike TSH, however, functions neuroendocrine system remain largely unexplored. Here, we identify functional thyrostimulin-like signaling in Caenorhabditis elegans . We show that together with...