A5003790642- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Ovarian cancer diagnosis and treatment
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Gastric Cancer Management and Outcomes
- Ultrasound and Hyperthermia Applications
- Genetic factors in colorectal cancer
- Cancer-related Molecular Pathways
- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Monoclonal and Polyclonal Antibodies Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Lipids, and Metabolism
- Breast Cancer Treatment Studies
- Peptidase Inhibition and Analysis
- Pain Management and Placebo Effect
- Musculoskeletal pain and rehabilitation
- Cancer and Skin Lesions
- Colorectal and Anal Carcinomas
- Spine and Intervertebral Disc Pathology
- Intraperitoneal and Appendiceal Malignancies
- Effects of Radiation Exposure
- Neutropenia and Cancer Infections
- RNA modifications and cancer
University of Haifa
2024
Western Galilee Hospital
2011-2024
Sheba Medical Center
2002-2018
Punjab Medical College
2017
Kaplan Medical Center
1995-2011
Can-Fite BioPharma (Israel)
2004-2006
Soroka Medical Center
2003-2006
Edmond and Lily Safra Children's Hospital
2006
Tel Aviv University
2001-2006
Rabin Medical Center
1987-2004
No AccessJournal of Urology1 May 1985Localized Deep Microwave Hyperthermia in the Treatment Poor Operative Risk Patients with Benign Prostatic Hyperplasia A. Yerushalmi, Y. Fishelovitz, D. Singer, I. Reiner, J. Arielly, Abramovici, R. Catsenelson, E. Levy, and Shani YerushalmiA. Yerushalmi , FishelovitzY. Fishelovitz SingerD. Singer ReinerI. Reiner AriellyJ. Arielly AbramoviciY. Abramovici CatsenelsonR. Catsenelson LevyE. Levy ShaniA. View All Author...
Abstract An increasing number of studies indicate that reduced DNA-repair capacity is associated with increased cancer risk. Using a functional assay for the removal oxidative DNA lesion 8-oxoguanine by enzyme glycosylase 1 (OGG1), we have previously shown OGG activity risk factor in lung cancer. Here, report peripheral blood mononuclear cells from 37 cases squamous cell carcinoma head and neck (SCCHN) was significantly lower than 93 control subjects, frequency matched age gender. Retesting...
To assess the response rate and tolerance of irinotecan as first-line therapy, 40 patients with metastatic gastric cancer received 350 mg m−2 every 3 weeks administered a 30 min infusion. Among 35 evaluable for response, two complete five partial responses were recorded (response rate: 20.0% (95% CI:8.4–36.9%)). In total, 16 achieved stable disease 12 progressive disease. all, 66 percent benefited from tumour growth control. The median time to progression was 3.0 months CI: 2.3–4.4%)....
Several studies have recently suggested that the immune response to malignant growths is regulated by distinct patterns of type 2 cytokine production. These cytokines, regulating cytotoxic T-lymphocyte in patients with advanced cancers, may be associated disease progression. Evidence suggests T Helper 1 (TH1) and (TH2) types reaction are reciprocally vivo. The immunomodulator AS101 (ammonium trichloro [dioxoethylene- O,O' ] tellurate) was found stimulate mouse human cells proliferate secrete...
The immunomodulator AS101 has been demonstrated to exhibit radioprotective and chemoprotective effects in mice. Following phase-I studies, preliminary results from phase-II clinical trials on non-small-cell-lung-cancer patients showed a reduction the severity of alopecia treated with combination chemotherapy. To further substantiate these findings, present study was extended include 58 either optimal dose 3 mg/m2 combined carboplatin VP-16, or chemotherapy alone. As compared alone, there...
PURPOSE The aim of this study was to evaluate the ability immunomodulator AS101 prevent chemotherapy-induced neutropenia and thrombocytopenia thus allow patients receive full-dose antineoplastic agents according protocol design. We also aimed determine production level various hematopoietic growth factors in treated patients. PATIENTS AND METHODS This 44 unresectable or metastatic non-small-cell lung cancer (NSCLC) an open-label prospective randomized standard chemotherapy alone versus plus...
Serial carcinoembryonic antigen (CEA) measurements were evaluated in a group of 263 patients undergoing systemic chemotherapy for metastatic colorectal carcinoma. Initial CEA levels not found to be value predicting the likelihood subsequent tumor response. Although general relation between serial and clinical was noted, these discordant substantial proportion patients. Tumor as an index response therapy strongly correlated with survival, whereas changes values patient survival at...
Abstract Fifty‐four patients from the surgical gastroenterology service and 22 healthy controls have been prospectively evaluated in a single‐blind protocol by LAI tube method. The correctly identified 25 of 33 early colorectal staged as Dukes' B C at surgery but none D patients. An inverse relationship was seen between results non‐adherence index (NAI) CEA levels which most pronounced those with advanced cancer. majority having “false negative” had level greater than 2.5 ng/ml, suggesting...
Optimal doses of paclitaxel (Taxol) combined with the immunomodulator AS101, previously shown to have anti-tumoral effects, administered B16 melanoma-bearing mice decreased tumor volume and resulted in over 60% cure. Paclitaxel+AS101 directly inhibited clonogenicity melanoma cells a synergistic, dose-dependent manner. We suggest that this results from both reduced paclitaxel-induced bone marrow toxicity induction differential signal-transduction pathways, which lead apoptosis cells....
Abstract Background We compared the efficacy and toxicity of oral capecitabine continuous infusion 5‐fluorouracil (5‐FU) in preoperative chemoradiation treatment patients with rectal cancer. Patients Methods The files 89 cancer, 43 treated preoperatively 46 intravenous 5‐FU, were reviewed, outcome groups was compared. Results There no statistically significant difference complete pathological response rate between 5‐FU (30% vs. 17%, P = 0.15). downstaging higher group (77% 50%, 0.009)....
Our objective was to determine maternal risk factors for developing intrapartum fever during term labor and evaluate perinatal outcomes infants exposed mothers with fever. We performed a retrospective cohort study of 330 their controls in single institution. Prolonged labor, nulliparity, disease, prolonged membrane rupture were found be the most significant predictors Caesarean section instrumental delivery more commonly performed. Bacteriuria present 10 % mothers. Babies born likely have...
3524 Background: The MOSAIC study (André T, N Engl J Med, 2004) demonstrated that adding oxaliplatin to adjuvant 5FU and LV improved three-year disease-free survival (DFS) in stage II III resected CC. Efficacy of FOLFOX4 pts with dMMR was suggested a retrospective (Zaanan A, Ann Oncol 2010). Methods: Of the 2,246 included study, formalin-fixed, paraffin-embedded (FFPE) tissue blocks or slides from 1,019 were obtained. Thirty-three samples insufficient tumor excluded this translational study....
To evaluate the impact of 12-gene Colon Cancer Recurrence Score Assay-a clinically validated prognosticator in stage II colon cancer after surgical resection-on adjuvant treatment decisions T3 mismatch repair proficient (MMR-P) clinical practice.This retrospective analysis included all patients with MMR-P (Clalit Health Services members) results (time frame January 2011 to May 2012). Treatment recommendations pretesting were compared treatments received. Changes categorized as decreased (to...
Abstract The immunomodulator ammonium trichloro(dioxyethylene-0-0')tellurate (AS101) has been shown to possess antitumoral properties in several murine models. In the present study, we demonstrate a synergistic vivo antitumor effect of AS101 and Taxol against early stage Madison 109 lung adenocarcinoma. Treatment with optimal doses (25 17 mg/kg) (0.5 resulted 66.6 43.3% cures. We propose that is result both direct indirect drugs on tumor cells. directly inhibited clonogenicity M109 cells...
The clinical electromagnetic hyperthermia system has been in use at the Kaplan Hospital since 1980, for treating patients with combined radio- or chemotherapy. For prostatic tumors, 43 degrees C is achieved mass using microwaves of 2.45 GHz, simultaneous cooling rectal mucosa and wall. Thirty-two carcinoma prostate have treated: 4 heat alone, 20 radiotherapy, 8 hormonal therapy. Follow-up was carried out up to 34 months. Objective local tumor regression 3 treated by but relapsed after 6 All...
ObjectivesWe determined how Israeli oncologists and family physicians value life-prolongation versus quality-of-life (QOL)-enhancing outcomes attributable to cancer congestive heart failure interventions.MethodsWe presented with two scenarios involving a hypothetical patient metastatic expected survive 12 months current treatment. In scenario, we suggested that new treatment increases survival at an incremental cost of $50,000 over the standard care. Participants were asked what minimum...