A5100713335- Obesity, Physical Activity, Diet
- Birth, Development, and Health
- Child Nutrition and Water Access
- Nutritional Studies and Diet
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Risk Factors
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Diet and metabolism studies
- Nutrition, Genetics, and Disease
- Health and Lifestyle Studies
- Cardiovascular Disease and Adiposity
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet, Metabolism, and Disease
- Health, Environment, Cognitive Aging
- Schizophrenia research and treatment
- Alkaloids: synthesis and pharmacology
- Genetic Associations and Epidemiology
- Hypothalamic control of reproductive hormones
- Traditional and Medicinal Uses of Annonaceae
- Ophthalmology and Visual Impairment Studies
- Eating Disorders and Behaviors
- Obesity and Health Practices
- Body Composition Measurement Techniques
- Gestational Diabetes Research and Management
Peking University
2016-2025
Southeast University
2025
National Health and Family Planning Commission
2020-2025
Zhongshan People's Hospital
2025
Shenzhen University
2025
Beijing Anzhen Hospital
2021-2025
Capital Medical University
2021-2025
Tianjin Medical University
2020-2025
People's Hospital of Xinjiang Uygur Autonomous Region
2025
Imperial College London
2021-2024
<h2>Summary</h2><h3>Background</h3> Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated individual combined prevalence of underweight or thinness obesity, their changes, from 1990 to 2022 for adults school-aged children adolescents in 200 countries territories. <h3>Methods</h3> used data 3663 population-based studies 222 million participants that measured height weight representative samples general population. a Bayesian hierarchical...
Brazil, Russia, India, China, and South Africa (BRICS) are emerging economies making up almost half the global population. We analyzed trends in cardiovascular disease (CVD) mortality across BRICS associations with age, period, birth cohort.Mortality estimates were derived from Global Burden of Disease Study 2017. used age-period-cohort modeling to estimate cohort period effects CVD between 1992 2016. Period was defined as survey year, reflect population-wide exposure at a circumscribed...
Air pollution has been associated with elevated blood pressure in adults. However, epidemiological evidence from children and adolescents is limited. We investigated the associations between long-term exposure to particulate matter (PM) air a large population of adolescents. A cross-sectional analysis was performed nationally representative sample consisting 43,745 aged 7 18 years seven provinces China. Exposure ambient fine particles (PM2.5) thoracic (PM10) estimated using spatiotemporal...
Based on the data from six Chinese National Surveys Students Constitution and Health (CNSSCH) 1985 to 2010, we explored secular trend in prevalence of obesity urban children over a period 25 years. The aim this study was examine gender disparities childhood time. standardized increased rapidly during past years 0.2% 8.1% 2010. increasing significant all age subgroups (p<0.01). Although continuously both boys girls, changing pace faster than that girls. Age-specific odds ratios (PORs) versus...
Background The association of dietary pattern with chronic diseases has been investigated widely in western countries. However, information is quite limited among children China. Our study aimed to identify the patterns Chinese and examine their obesity related cardiometabolic risk factors. Methods A total 5267 were selected using multistage random sampling from 30 primary schools 5 provincial capital cities Dietary intake was derived 24 hour recall for three consecutive days. Anthropometric...
Abstract Objectives To outline which infectious diseases in the pre-covid-19 era persist children and adolescents China to describe recent trends variations by age, sex, season, province. Design National surveillance studies, 2008-17. Setting 31 provinces mainland China. Participants 4 959 790 Chinese students aged 6 22 years with a diagnosis of any 44 notifiable diseases. The were categorised into seven groups: quarantinable; vaccine preventable; gastrointestinal enteroviral; vectorborne;...
The prevalence of obesity among children and adolescents has been rapidly rising in Mainland China recent decades, both urban rural areas. There is an urgent need to develop effective interventions prevent childhood obesity. Limited rigid data regarding adolescent overweight prevention are available. A national random controlled school-based intervention program was developed the mainland China. study designed as a multi-centered cluster randomized trial involving more than 70,000 aged 7–18...
We sought to develop and validate a national blood pressure (BP) reference based on age, sex, height for Chinese children. Data were obtained 197 430 children aged 7 17 who participated in the National Survey Students’ Constitution Health 2010. BP percentiles estimated fitted using lambda, mu, sigma method then compared with US China existing reference. In an external independent validation sample of 59 653 18 from provinces 2013, prevalence elevated was applying 3 references. values similar...
FTO (fat mass and obesity associated gene) was genetically identified to be with body index (BMI), presumably through functional regulation of energy homeostasis. However, the cellular molecular mechanisms by which functions remain largely unknown. Using 3T3-L1 preadipocyte as a model study role in adipogenesis, we demonstrated that is functionally required for differentiation. knock-down siRNA inhibited differentiation, whereas ectopic over-expression enhanced process. The demethylase...
The current study aimed to assess the secular trends in overweight and obesity status high blood pressure (HBP) Chinese children adolescents for 2 decades. Data on 943 128 participants aged 7 17 years were obtained from National Survey Students' Constitution Health 1995 2014. population attributable risk of HBP was calculated. prevalence increased 4.3% 18.4% 2014, whereas fluctuated range 4.4% 6.4% during same time period, lowest 2005. Within each survey year, levels with higher body mass...
The prevalence of metabolic syndrome (MetS) rapidly increased over the past decades. However, little evidence exists about effects long-term exposure to ambient air pollution on MetS in children and adolescents. This study aims assess association between a large population Chinese In 2013, total 9,897 adolescents aged 10 18 years were recruited from seven provinces/municipalities China. was defined based recommendation by International Diabetes Federation (IDF). Satellite spatio-temporal...
Abstract Optimal growth and development in childhood adolescence is crucial for lifelong health well-being 1–6 . Here we used data from 2,325 population-based studies, with measurements of height weight 71 million participants, to report the body-mass index (BMI) children adolescents aged 5–19 years on basis rural urban place residence 200 countries territories 1990 2020. In 1990, residing cities were taller than their counterparts all but a few high-income countries. By 2020, advantage...
An enantiospecific method for the synthesis of 4-methoxytryptophan has been developed via a regiospecific Larock heteroannulation and employed first total syntheses 9-methoxygeissoschizol 9-methoxy-Nb-methylgeissoschizol, as well opioid agonistic alkaloid mitragynine. The asymmetric Pictet-Spengler reaction Ni(COD)2-mediated cyclization served key steps.
Glecaprevir (formerly ABT-493) is a novel hepatitis C virus (HCV) NS3/4A protease inhibitor (PI) with pangenotypic activity. It inhibited the enzymatic activity of purified proteases from HCV genotypes 1 to 6
Childhood obesity has been a serious public health problem. An effective school-based physical activity (PA) intervention is still lacking in China. This study aimed to assess the effectiveness of during 12 weeks on and related outcomes school children. It was non-randomized controlled trial. Altogether 921 children aged 7 15 years were recruited at baseline survey. Children group (n = 388) participated multi-component that included improvement education, extracurricular activities for...
Gene polymorphisms associated so far with body mass index (BMI) can explain only 1.18–1.45% of observed variation in BMI. Recent studies suggest that epigenetic modifications, especially DNA methylation, could contribute to part the missing heritability, and two genome-wide analysis (EWAS) have reported Hypoxia Inducible Factor 3 Alpha Subunit (HIF3A) methylation was BMI or change. We therefore assessed whether HIF3A is obesity other obesity-related phenotypes Chinese children. The subjects...