A5002251810- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Animal Vocal Communication and Behavior
- Animal Behavior and Reproduction
- Neuroscience and Neuropharmacology Research
- Neuroscience and Music Perception
- Neuroscience and Neural Engineering
- Marine animal studies overview
- Face Recognition and Perception
- Memory and Neural Mechanisms
- Epilepsy research and treatment
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Creativity in Education and Neuroscience
- Multisensory perception and integration
- Plant and animal studies
- Reading and Literacy Development
- Olfactory and Sensory Function Studies
- Visual perception and processing mechanisms
- Obsessive-Compulsive Spectrum Disorders
- Genetic Neurodegenerative Diseases
- Sleep and Wakefulness Research
- Cellular transport and secretion
Centre National de la Recherche Scientifique
2014-2025
Sorbonne Université
2016-2025
Institut du Cerveau
2015-2025
Inserm
2014-2025
Allen Institute for Brain Science
2019-2025
Assistance Publique – Hôpitaux de Paris
2015-2024
Pitié-Salpêtrière Hospital
2013-2024
Université Paris Cité
2017-2024
Fondation de l'Avenir
2017-2022
Institut de Psychiatrie et Neurosciences de Paris
2022
Trial-by-trial variability in perceptual performance on identical stimuli has been related to spontaneous fluctuations ongoing activity of intrinsic functional connectivity networks (ICNs). In a paradigm requiring sustained vigilance for instance, we previously observed that higher prestimulus cingulo-insular-thalamic network facilitated subsequent perception. Here, test our proposed interpretation this underpins maintenance tonic alertness. We used simultaneous acquisition magnetic...
Neural oscillations in the alpha band (8–12 Hz) are increasingly viewed as an active inhibitory mechanism that gates and controls sensory information processing a function of cognitive relevance. Extending this view, phase synchronization across distant cortical regions could regulate integration information. Here, we investigated whether such long-range cross-region coupling is intrinsically selectively linked to activity distinct functionally specialized brain network. If so, would provide...
The physiological basis of human cerebral asymmetry for language remains mysterious. We have used simultaneous and anatomical measurements to investigate the issue. Concentrating on neural oscillatory activity in speech-specific frequency bands exploring interactions between gestural (motor) auditory-evoked activity, we find, absence language-related processing, that left auditory, somatosensory, articulatory motor, inferior parietal cortices show specific, lateralized, speech-related...
Good scientific practice (GSP) refers to both explicit and implicit rules, recommendations, guidelines that help scientists produce work is of the highest quality at any given time, efficiently share with community for further scrutiny or utilization. For experimental research using magneto- electroencephalography (MEEG), GSP includes specific standards technical competence, which are periodically updated adapted new findings. However, also needs be regularly revisited in a broader light. At...
SUMMARY Song geographic variation and Neighbour–Stranger (N–S)discrimination have been intensively but separately studied in bird species,especially those with small- to medium-sized repertoires. Here, we establish a link between the two phenomena by showing that dialect features are used for N–S recognition territorial species large repertoire, skylark Alauda arvensis. In this species, during breeding season, many pairs settle stable adjoining territories gathered locations spaced few...
The aim of the present study was to explore auditory cortical oscillation properties in developmental dyslexia. We recorded activity 17 dyslexic participants and 15 matched controls using simultaneous EEG fMRI during passive viewing an audiovisual movie. compared distribution brain oscillations delta, theta gamma ranges over left right cortices. In controls, our results are consistent with hypothesis that there is a dominance hemisphere delta-theta hemisphere. dyslexics, we did not find such...
Subjects with autism often show language difficulties, but it is unclear how they relate to neurophysiological anomalies of cortical speech processing. We used combined EEG and fMRI in 13 subjects control participants that autism, gamma theta activity do not engage synergistically response speech. Theta left auditory cortex fails track modulations the group down-regulate oscillations. This deficit predicts severity both verbal impairment symptoms affected sample. Finally, we found...
Prediction is held to be a fundamental process underpinning perception, action, and cognition. To examine the time course of prediction error signaling, we recorded intracranial EEG activity from nine presurgical epileptic patients while they listened melodies whose information theoretical predictability had been characterized using computational model. We examined oscillatory in superior temporal gyrus (STG), middle (MTG), pars orbitalis inferior frontal gyrus, lateral cortical areas...
How do attention and consciousness interact in the human brain? Rival theories of disagree on role fronto-parietal attentional networks conscious perception. We recorded neural activity from 727 intracerebral contacts 13 epileptic patients, while they detected near-threshold targets preceded by cues. Clustering revealed three patterns: first, attention-enhanced report accompanied sustained right-hemisphere fronto-temporal connected superior longitudinal fasciculus (SLF) II-III, late...
Between seizures the brain of patients with epilepsy generates pathological patterns synchronous activity, designated as interictal epileptiform discharges (ID). Using microelectrodes in hippocampal formations 8 drug-resistant temporal lobe epilepsy, we studied ID by simultaneously analyzing action potentials from individual neurons and local field generated surrounding neuronal network. We found that ~ 30% units increased their firing rate during 40% showed a decrease post-ID period....
Exogenous attention, the process that makes external salient stimuli pop-out of a visual scene, is essential for survival. How attention-capturing events modulate human brain processing remains unclear. Here we show how psychological construct exogenous attention gradually emerges over large-scale gradients in cortex, by analyzing activity from 1,403 intracortical contacts implanted 28 individuals, while they performed an task. The timing, location and task-relevance attentional defined...
Leucin-rich, glioma inactivated 1 (LGI1) is a secreted protein linked to human seizures of both genetic and autoimmune aetiology. Mutations in the LGI1 gene are responsible for autosomal dominant temporal lobe epilepsy with auditory features, whereas autoantibodies involved limbic encephalitis, an acquired epileptic disorder associated cognitive impairment. We others previously reported that Lgi1-deficient mice have early-onset spontaneous leading premature death at 2–3 weeks age. Yet, where...
Face perception is thought to be mediated by neural activity in the occipital and posterior temporal cortex.1,2 However, face-selective neurons at cellular level these areas humans have never been demonstrated. We had a rare opportunity record intracranial multi-unit an epilepsy patient near fusiform face area2 (figure 1A). identified 2 units with highly response static images of familiar (famous) unfamiliar faces 1B video 1; figure e-1a, doi.org/10.5061/dryad.81t0fq1) as well human animal...
Stimulation and functional imaging studies have revealed the existence of a large network cortical regions involved in regulation heart rate. However, very little is known about link between neural firing cardiac-cycle duration (CCD). Here, we analyze single-unit multiunit data obtained humans at rest, show that rate covaries with CCD 16.7% sample (25 150). The was most prevalent anterior medial temporal lobe (entorhinal perirhinal cortices, hippocampus, amygdala), where 36% (18 50) units...
Freezing of gait (FOG) is a significant disability in Parkinson disease (PD). Deep brain stimulation (DBS) the subthalamic nucleus (STN) only partially alleviates it, with approximately one-third patients experiencing worsening FOG within year after surgery. The precise role STN dysfunction disabilities and remains not fully elucidated. To investigate this, we recorded local field potential (LFP) activity 38 PD patients, both Off On dopamine medication. Our analysis focused on relationship...
Some decisions, such as selecting a food item in novel menu, are not based on rational norms, or trained habits, but subjective preferences. How the human brain makes these preference-based decisions is still debated cognitive neuroscience. Classical models focus comparison mechanism that achieves selection of option with best expected value. Recent suggest estimates values refined until reaching sufficient confidence considered choice. Neuroimaging studies humans and electrophysiology...
Extinction learning – the suppression of a previously acquired fear response is critical for adaptive behavior and core understanding etiology treatment anxiety disorders. Electrophysiological studies in rodents have revealed roles theta (4-12Hz) oscillations amygdala hippocampus during both extinction, engram research has shown that extinction relies on formation novel, highly context-dependent memory traces suppress initial memories. Whether similar processes occur humans how they relate...
Human neuronal activity, recorded in vivo from microelectrodes, may offer valuable insights into physiological mechanisms underlying human cognition and pathophysiological of brain diseases, particular epilepsy. Continuous long-term recordings are necessary to monitor non predictable pathological activities like seizures or sleep. Because their high impedance, microelectrodes more sensitive noise than macroelectrodes. Low levels crucial detect action potentials background noise, further...
Abstract The notion that past choices affect preferences is one of the most influential concepts social psychology since its first report in 50 s, and theorization within cognitive dissonance framework. In free-choice paradigm (FCP) after choosing between two similarly rated items, subjects reevaluate chosen items as more attractive rejected less attractive. However relations prevailing episodic memory choice-induced preference change (CIPC) remain highly debated: this phenomenon dependent...
Certain motor activities - like walking or breathing present the interesting property of proceeding either automatically under voluntary control. In case breathing, brainstem structures located in medulla are charge automatic mode, whereas cortico-subcortical brain networks including various frontal lobe areas subtend mode. We speculated that involvement cortical activity during could impact both on “resting state” pattern cortical-subcortical connectivity, and recruitment executive...
To what extent seasonal factors modify the neuronal functional properties within nuclei of avian song system remains an open question. In adult songbirds, neurons premotor nucleus HVC (used as a proper name) exhibit selective responses for bird's own (BOS). Here we examine whether, outside breeding season, when songs are less stereotyped, male canaries still respond selectively to BOS produced during this period. initial experiment, single-unit recordings ( n = 114) revealed that selectivity...