A5100770263- Acute Ischemic Stroke Management
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Neurological Disorders and Treatments
- Cancer-related molecular mechanisms research
- Plant biochemistry and biosynthesis
- Genetic diversity and population structure
- S100 Proteins and Annexins
- Ferroptosis and cancer prognosis
- Advanced Neuroimaging Techniques and Applications
- Stroke Rehabilitation and Recovery
- Cardiovascular Health and Disease Prevention
- MicroRNA in disease regulation
- Nitric Oxide and Endothelin Effects
- Epigenetics and DNA Methylation
- Cardiovascular Health and Risk Factors
- Scoliosis diagnosis and treatment
- Advanced Glycation End Products research
- Calpain Protease Function and Regulation
- Genomics and Phylogenetic Studies
- Renin-Angiotensin System Studies
- Pregnancy and preeclampsia studies
- Photosynthetic Processes and Mechanisms
- Protein Degradation and Inhibitors
Medical University of South Carolina
2019-2025
Tianjin University
2022-2025
Henan Polytechnic University
2017-2025
Shaoxing University
2022-2025
Ralph H. Johnson VA Medical Center
2019-2024
Henan University
2023
First Affiliated Hospital of Fujian Medical University
2022
Fujian Medical University
2022
Henan Normal University
2018-2022
Qilu Hospital of Shandong University
2020
Pre-existing diabetes mellitus worsens brain functionality in ischemic stroke. We have previously shown that type 2 diabetic rats exhibit enhanced dysfunctional cerebral neovascularization and when these are subjected to reperfusion injury develop hemorrhagic transformation greater neurological deficits. However, our knowledge of vascular functional plasticity during the recovery phase stroke is limited. This study tested hypothesis repair impaired poststroke period mellitus, this associated...
Diabetes impedes vascular repair and causes vasoregression in the brain after stroke, but mechanisms underlying this response are still unclear. We hypothesized that excess peroxynitrite formation diabetic ischemia/reperfusion (I/R) injury inactivates p85 subunit of phosphoinositide 3-kinase (PI3K) by nitration diverts PI3K–Akt survival signal to p38–mitogen-activated protein kinase apoptosis pathway. Nitrotyrosine (NY), Akt p38 activity, nitration, caspase-3 cleavage were measured brains...
In Brief Study Design. A prospective study was designed to investigate the circulating leptin level in girls with adolescent idiopathic scoliosis (AIS). Objective. To determine levels AIS girls, and its associations body mass bone mass. Summary of Background Data. Abnormal growth pattern osteopenia have been well documented patients throughout peripubertal period. Leptin has shown regulate whole particularly during childhood adolescence. However, leptin, relationships between lower mass,...
To observe the efficacy and side effects of liraglutide in treatment type 2 diabetes mellitus (T2DM) patients with severe obstructive sleep apnea (OSA).The study conducted an outpatient setting was a two-center, prospective randomized controlled study. T2DM OSA were to control group (continuous positive airway pressure [CPAP] drug without liraglutide) or (CPAP including liraglutide). Demographic clinical characteristics, sleep-disordered breathing indices, cardiac function evaluated compared...
Dysregulation of cerebral vascular function and, ultimately, blood flow (CBF) may contribute to complications such as stroke and cognitive decline in diabetes. We hypothesized that 1) diabetes-mediated neurovascular myogenic dysfunction impairs CBF 2) under hypoxic conditions, vessels from diabetic rats lose properties because peroxynitrite (ONOO(-))-mediated nitration smooth muscle (VSM) actin. Functional hyperemia, the ability dilate upon neuronal stimulation, tone isolated middle arteries...
Hemorrhagic transformation is an important complication of acute ischemic stroke, particularly in diabetic patients receiving thrombolytic treatment with tissue plasminogen activator, the only approved drug for stroke. The objective present study was to determine effects manipulation potential targets vascular protection [i.e., NF-κB, peroxynitrite, and matrix metalloproteinases (MMPs)] on injury functional outcome a model cerebral ischemia. Ischemia induced by middle artery occlusion...
Diabetes increases the risk and severity of cognitive impairment, especially after ischemic stroke. Pathological remodeling cerebrovasculature has been postulated to contribute poor neuronal repair worsened deficits in diabetes. However, little is known about effect diabetes on vascularization hippocampus, a domain critical memory learning. Therefore, we had two aims for this study: 1) determine impact hippocampal neurovascular resulting impairment stroke using models with varying disease...
Minocycline provides neurovascular protection reducing acute cerebral injury. However, it is unclear whether minocycline effective in females. We tested both sexes and aged animals using a novel embolic stroke model mice that closely mimics thromboembolic humans.Five groups of were subjected to stroke: adult males, females, ovariectomized They treated with phosphate saline (vehicle) or (6 mg/kg) immediately after onset. Behavioral outcomes, infarct volumes blood flow assessed. The effect on...
Introduction: Cerebrovascular pathologies leading to VCID are diverse, but preclinical models mainly rely on chronic hypoperfusion-mediated neuroinflammation in otherwise healthy animals. Since diabetes increases risk, our first goal was develop a multi-etiology model of diabetes. Given that endothelin-1 (ET-1) contributes decreased cerebral blood flow multiple dementia and ETAR-mediated senescence brain microvascular endothelial cells, second assess ETARs this model. Methods: Control...
20-Hydroxyeicosatetraenoic acid (20-HETE), Cyp4a-derived eicosanoid, is a lipid mediator that promotes tumor growth, as well causing detrimental effects in cerebral circulation. We determined whether concurrent inhibition of cyclooxygenase-2 (COX-2) and 20-HETE affects colon growth ischemic stroke outcomes. The expression Cyp4a COXs production PGE2 were murine carcinoma (MC38) cells. then examined the combined treatment with rofecoxib, potent COX-2 inhibitor, HET0016, on proliferation MC38...
Obesity and high fat intake induce alterations in vascular function structure. Aberrant O-GlcNAcylation (O-GlcNAc) of proteins has been implicated dysfunction associated with cardiovascular metabolic diseases. In the present study, we tested hypothesis that high-fat diet (HFD)-mediated increases O-GlcNAc-modified contribute to cerebrovascular dysfunction. O-GlcNAc-protein content was increased arteries from male Wistar rats treated a HFD (45% fat) for 12 weeks compared on control (CD)....
The myogenic response is crucial for maintaining vascular resistance to achieve constant perfusion during pressure fluctuations. Reduced cerebral blood flow has been reported in ischemic and nonischemic hemispheres after stroke. Ischemia-reperfusion injury the resulting oxidative stress impair responses hemisphere. Yet, mechanism by which ischemia-reperfusion affects side still undetermined. goal of present study was determine effect on reactivity vessels from both whether protein nitration...
The increasing use of ionizing radiation (IR) in medical diagnosis and treatment has caused considerable concern regarding the effects occupational exposure on human health. Despite this concern, little information is available possible mechanism behind chronic low-dose irradiation. present study assessed potential genomic damage workers occupationally exposed to X-rays. A variety analyses were conducted, including assessing level DNA chromosomal aberrations (CA) as well cytokinesis-block...