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A5068866981
Research Areas
- interferon and immune responses
- Telomeres, Telomerase, and Senescence
- Cytomegalovirus and herpesvirus research
Université de Montréal
2020
Abstract Cellular senescence is a known driver of carcinogenesis and age-related diseases, yet required for various physiological processes. However, the mechanisms factors that control negative effects while retaining its benefits are still elusive. Here, we show rasGAP SH3-binding protein 1 (G3BP1) activation senescent-associated secretory phenotype (SASP). During senescence, G3BP1 achieves this effect by promoting association cyclic GMP-AMP synthase (cGAS) with cytosolic chromatin...
10.1038/s41467-020-18734-9
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Nature Communications
2020-10-05
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