A5079350808- Cell death mechanisms and regulation
- Cancer-related Molecular Pathways
- Glioma Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- CAR-T cell therapy research
- Cell Adhesion Molecules Research
- Toxin Mechanisms and Immunotoxins
- interferon and immune responses
- Cancer Research and Treatments
- Proteoglycans and glycosaminoglycans research
- NF-κB Signaling Pathways
- Axon Guidance and Neuronal Signaling
- Transgenic Plants and Applications
- Cancer Cells and Metastasis
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Cell Function and Interaction
- CRISPR and Genetic Engineering
- Immune cells in cancer
- Single-cell and spatial transcriptomics
- Signaling Pathways in Disease
- Histone Deacetylase Inhibitors Research
- Viral Infectious Diseases and Gene Expression in Insects
- DNA Repair Mechanisms
- Barrier Structure and Function Studies
University of Tübingen
2014-2024
Hertie Institute for Clinical Brain Research
2015-2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2019-2024
Universitätsklinikum Erlangen
2019-2024
IQVIA (United Kingdom)
2022-2024
BC Cancer Agency
2012
UNSW Sydney
2009-2010
Universitätsklinikum Tübingen
2000-2001
In-Q-Tel
1999
University of Würzburg
1991-1997
Background CXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails couple G-proteins and induce typical mediated cellular responses. The function of controversial. Some studies suggest a signaling activity in mammalian cells zebrafish embryos, while others indicate decoy fish. Here we investigated two propositions human tissues. Methodology/Principal Findings We provide evidence mechanistic insight that acts as...
Abstract Macrophages are thought to represent a first line of defense in anti‐tumor immunity. Despite infiltration by microglial cells, however, malignant gliomas still highly aggressive tumors. We here identify monocyte chemoattractant protein‐1 (MCP‐1) as critical for glioma‐infiltrating cells. MCP‐1–transfected rat CNS‐1 were massively infiltrated Whereas MCP‐1 did not promote the growth cells vitro, intracerebral CNS‐1–transfected tumors grew more aggressively than control‐transfected...
APO2L (TRAIL) is a novel CD95L (Fas/APO‐1‐L) homologous cytotoxic cytokine that interacts with various receptors which transmit (DR4, DR5) or inhibit (DcR1, DcR2) an apoptotic signal. Here, we report human glioma cell lines preferentially express mRNAs for agonistic death DR4 (8/12) and DR5 (11/12) rather than the death‐inhibitory decoy DcR1 (4/12) DcR2 (2/12). Ten of 12 are susceptible to APO2L‐induced apoptosis. The resistant lines, U138MG U373MG, cross‐resistant CD95L‐induced Similar...
Axonal regeneration and related functional recovery following axonal injury in the adult central nervous system are extremely limited, due to a lack of neuronal intrinsic competence presence extrinsic inhibitory signals. As opposed what occurs during development, weak proregenerative gene expression programme contributes limited capacity injured axons regenerate. Here we show, an optic nerve crush model injury, that adenoviral (cytomegalovirus promoter) overexpression acetyltransferase p300,...
The blood–brain barrier (BBB) is a selectively permeable boundary that separates the circulating blood from extracellular fluid of brain and an essential component for homeostasis. In glioblastoma (GBM), BBB peritumoral vessels often disrupted. Pericytes, being important to maintaining integrity, can be functionally modified by GBM cells which induce proliferation cell motility via TGF-β-mediated induction central epithelial mesenchymal transition (EMT) factors. We demonstrate pericytes...
Central nervous system (CNS)-resident cells such as microglia, oligodendrocytes and astrocytes are gaining increasing attention in respect to their contribution CNS pathologies including multiple sclerosis (MS). Several studies have demonstrated the involvement of pro-inflammatory glial subsets pathogenesis propagation inflammatory events MS its animal models. However, it has only recently become clear that underlying heterogeneity microglia can not drive inflammation, but also lead...
Sildenafil, an inhibitor of the cGMP-degrading phosphodiesterase 5 that is used to treat erectile dysfunction, has been linked increased risk melanoma. Here, we have examined potential connection between cGMP-dependent signaling cascades and melanoma growth. Using a combination biochemical assays real-time monitoring cells, report growth-promoting pathway in murine human cells. We document C-type natriuretic peptide (CNP), ligand membrane-bound guanylate cyclase B, enhances activity protein...
Astrocytes are the most abundant glial cells in central nervous system (CNS) with capacity to sense and react injury inflammatory events. While it has been widely documented that astrocytes can exert tissue-degenerative functions, less is known about their protective disease-limiting roles. Here, we report upregulation of pleiotrophin (PTN) by mouse human multiple sclerosis (MS) its preclinical model experimental autoimmune encephalomyelitis (EAE). Using CRISPR-Cas9-based genetic...
TGF-beta is a putative mediator of immunosuppression associated with malignant glioma and other types cancer. Subtilisin-like proprotein convertases such as furin are thought to mediate processing. Here we report that human cell lines express mRNA protein, exhibit furin-like protease (FLP) activity, release active into the culture supernatant. FLP activity not modulated by exogenous or neutralizing Abs. Exposure LN-18 T98G inhibitor, decanoyl-Arg-Val-Lys-Arg-chloromethylketone, inhibits...