A5036205645- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Streptococcal Infections and Treatments
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Kawasaki Disease and Coronary Complications
- Systemic Lupus Erythematosus Research
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Bacterial Identification and Susceptibility Testing
- COVID-19 and Mental Health
- Gout, Hyperuricemia, Uric Acid
- Pneumonia and Respiratory Infections
- Cystic Fibrosis Research Advances
- Urinary Bladder and Prostate Research
- Healthcare cost, quality, practices
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lymphatic Disorders and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Pneumocystis jirovecii pneumonia detection and treatment
- Chronic Disease Management Strategies
- Thermal Regulation in Medicine
- Biomarkers in Disease Mechanisms
- Eosinophilic Disorders and Syndromes
- Immunotherapy and Immune Responses
Pharmerit (United States)
2025
Ariel University
2022-2024
Edmond and Lily Safra Children's Hospital
2008-2023
Sheba Medical Center
2011-2023
Tel Aviv University
2011-2023
Agency for Healthcare Research and Quality
2023
Hospital for Sick Children
1957-2020
University of Toronto
1957-2018
SickKids Foundation
1957-2018
Center for Rheumatology
2011
To describe the features and treatment of macrophage activation syndrome (MAS) in a single-center cohort patients with childhood-onset systemic lupus erythematosus (SLE), to compare SLE manifestations outcomes between those without MAS.We included all followed up at The Hospital for Sick Children from 2002 2012, identified also diagnosed as having MAS. Demographic, clinical, laboratory MAS SLE, medication use, hospital pediatric intensive care unit (PICU) admissions, well damage indices...
Congenital defects of lymphatics in infancy are manifested by chylous ascites, chylothorax and lymphedema. One case congenital ascites two cases chylothorax, added to the literature. Eight [See FIG. 11. Source Pdf.] lymphedema reviewed from hospital records with a follow-up study. No mention combinations these manifestations was found A report is presented some experimental work chylothorax. Numerous large lymphatic spaces were present intestinal mesentery, serosa bowel villi. The...
Systemic lupus erythematosus (SLE) comprise a diverse range of clinical manifestations. To date, more than 30 single gene causes lupus/lupus like syndromes in humans have been identified. In the setting, identifying underlying molecular diagnosis is challenging due to phenotypic and genetic heterogeneity.We employed whole exome sequencing (WES) patients presenting with childhood-onset severe and/or atypical presentations identify cases that are explained by single-gene (monogenic) cause.From...
FMF results from mutations in the Mediterranean fever (MEFV) gene. The p. E148Q protein alternation is one of most frequent MEFV gene, yet exact genotype-phenotype correlation remains unclear. aim this study was to examine clinical significance heterozygous variant a paediatric cohort.We compared manifestations and disease severity score four genetic subgroups: (group 1) patients harbouring single (n = 6); 2) M694V 88); 3) compound variants 36); 4) homozygotes for 160).Of 646 children our...
The Cystic Fibrosis (CF) Impact Questionnaire (CF-IQ) was qualitatively developed to assess the impact of CF in context treatment advancements and increased longevity. This study reports CF-IQ validation. In this noninterventional validation study, people with completed 40-item validating patient-reported outcome measures (PROMs) via electronic diaries at enrollment (baseline) 4-week follow-up. Validation consisted modern methods focus groups finalize structural validity, classical internal...
Abstract The pathogenesis of juvenile idiopathic arthritis (JIA) is thought to involve multiple components the cellular immune system, including subsets γδ T cells. In this study, we conducted experiments define functional roles one major synovial fluid (SF) cell subsets, Vγ9+Vδ2+ (Vγ9+) cells, in JIA. We found that as opposed CD4+ equally high percentages (∼35%) Vγ9+ cells SF and peripheral blood (PB) produced TNF-α IFN-γ. Furthermore, stimulation with isopentenyl pyrophosphate (IPP), a...
Objective Macrophage activation syndrome (MAS), a life-threatening inflammatory complication, is increasingly recognized in childhood-onset systemic lupus erythematosus (cSLE). It can be challenge to differentiate active cSLE from MAS. We generated decision rules for discriminating MAS newly diagnosed patients. Methods conducted retrospective cohort study of consecutive, diagnosed, patients with fever, requiring hospital admission The Hospital Sick Children January 2003 December 2007 (cohort...
Objective. To analyze γδT cell subsets in peripheral blood (PB) and synovial fluid (SF) of patients with juvenile idiopathic arthritis (JIA), to correlate clinical characteristics. Methods. as percentages CD3+ T cells samples PB (n = 25) SF 93) were analyzed by flow cytometry 93 JIA patients. The percentage Vγ9+ after 10 days vitro expansion either interleukin 2 (IL-2) or isopentenyl pyrophosphate (IPP) plus IL-2 was determined. Results. Both Vδ1+ detected all patients, but only the higher...
To postulate that ADHD is a potential risk factor for COVID-19 infection; to evaluate the on drug-treated subjects.A retrospective chart review was performed subjects aged 6 18 years in Israel, who had undergone at least one test during study period.Of 64,409 included study, 6,207 (9.64%) positive result, 13,300 (20.65%) were diagnosed with ADHD, and of whom 1,751 (13%) purchased two medications 3 months prior testing defined as being medically treated. Medically-treated significantly lower...
Three aims: to elucidate determinants associated with COVID-19 vaccine uptake in children and the association parental vaccination; compare rates of PCR-positive SARS-CoV-2 results between vaccinated unvaccinated children; estimate rate vaccination its their children.We performed a retrospective chart review all aged 5-11 years registered at central district Israel from November 21st, 2021 April 30th, 2022, characterized vs. individuals. Data retrieved electronic medical files included:...
We aimed to examine rates of COVID-19 vaccination elucidate the need for targeted public health interventions. retrospectively reviewed electronic medical files all adults registered in a central district Israel from 1 January 2021 31 March 2022. The population was characterized by status against and number doses received. Univariate multivariable analyses were used identify predictors low that required Of 246,543 subjects included study, 207,911 (84.3%) vaccinated. minority groups...
Familial Mediterranean Fever (FMF) is the most common monogentic autoinflammatory disease. FMF results from mutations in MEFV, which lead to a pro-inflammatory state and increased production of Interleukin 1 beta subunit (IL-1b) by myeloid cells. Despite overall positive obtained with anti-IL-1 agents patients, little known about long-term growth impact these drugs pediatric population.To assess body weight height trajectories children treated agents.We conducted retrospective analysis 646...
Familial Mediterranean Fever (FMF) patients are required to adhere a life-long treatment with colchicine, primarily for preventing amyloidosis. As some may be asymptomatic long periods of time, it remains unclear whether is possible discontinue colchicine in selective group patients. We aimed identify predictive characteristics successful cessation therapy.Out 646 FMF pediatric followed our referral clinic, was discontinued 51 In this study we compared the genetic, demographic, and clinical...
Abstract Rapid advances in precision medicine promise dramatic reductions morbidity and mortality for a growing array of conditions. To realize the benefits minimize harm, it is necessary to address real-world challenges encountered translating this research into practice. Foremost among these how choose use modalities practice by addressing issues related caring sizable proportion people living with multimorbidity. Precision needs be delivered broader context care account factors that...
Background/Purpose: Macrophage activation syndrome (MAS), a life-threatening inflammatory emergency of children with rheumatic diseases, is increasingly recognized in pediatric systemic lupus erythematosus (pSLE). The challenge to differentiate active pSLE from MAS order make correct treatment decisions. purpose this study generate decision tree for the recognition newly diagnosed and test performance these proposed criteria an independent cohort. Methods: A retrospective cohort...
Background: We aimed to elucidate variables associated with coronavirus disease 2019 (COVID-19) vaccine compliance in adolescents and devise targeted interventions. Our secondary aim was compare the rates of severe acute respiratory syndrome 2 infection, hospitalizations deaths between vaccinated unvaccinated adolescents. Methods: A retrospective review electronic medical records performed on all 12–17 years age registered at Clalit Health District Israel during January 1, 2021, November 18,...
We aimed to investigate the effectiveness of an antibiotic stewardship program (ASP) on prescription in children with community-acquired pneumonia (CAP). Antibiotic purchasing data were collected for aged 3 months 18 years diagnosed CAP from November 2016 April 2017 (pre-intervention period) and 2018 (post-intervention period). The intervention was a 1-day seminar primary care pediatricians diagnosis treatment according national guidelines. There substantial decrease use azithromycin after...
ABSTRACT We evaluated the effect of infrared thermography (IRT) on clinical assessment bacterial and viral pharyngitis its impact predictive value McIsaac score algorithm for streptococcal in children. also investigated if IRT could distinguish between pharyngitis. The study included children aged 2–17 years presenting with sore throat fever over 38°C from November 1, 2021, to April 30, 2022. Of 76 assessed children, 16 were excluded due missing data or technical issues, leaving 60 (32...