A5039434883- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Sirtuins and Resveratrol in Medicine
- Cardiovascular Disease and Adiposity
- Autophagy in Disease and Therapy
- Organ Transplantation Techniques and Outcomes
- Vitamin D Research Studies
- Diabetes Treatment and Management
- Parathyroid Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Body Contouring and Surgery
- Cardiac Ischemia and Reperfusion
- Growth Hormone and Insulin-like Growth Factors
- Chronic Kidney Disease and Diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pituitary Gland Disorders and Treatments
- Magnesium in Health and Disease
- Diabetes Management and Research
- Cannabis and Cannabinoid Research
- Marine Toxins and Detection Methods
- Pharmaceutical and Antibiotic Environmental Impacts
- Ion channel regulation and function
- Bone health and osteoporosis research
Hospital de São João
2012-2024
Universidade do Porto
2012-2024
Universidad de la República de Uruguay
2024
Centro Hospitalar de Lisboa Ocidental
2023
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2018-2022
Faculdade de Medicina do ABC
2022
IPO Porto
2021
University of Coimbra
2010-2020
Manchester Academic Health Science Centre
2020
University of Manchester
2020
Nanoparticles (NPs) have increasingly been studied due to their probable harmful effects both humans and the environment. However, despite several indications of possible effects, no long-term studies using a low dose silver nanoparticles (AgNP) conducted in vivo.Our data demonstrate that prolonged exposure very AgNP was sufficient cause alterations hepatic mitochondrial function. Mitochondrial function compromised by AgNPs is recovered pretreatment with antioxidant N-acetylcysteine, which...
Fatty livers are considerably more susceptible to acute stressors, such as ischaemia/reperfusion (I/R). As the incidence of I/R is high due surgical events and some pathologies, there an urgent need find strategies against injury (I/RI) in fatty livers. We postulate that pretreatment with indirubin-3'-oxime (Ind) or NAD+ prevents mitochondrial dysfunction associated warm I/RI livers.Zucker rats were subjected ischaemia 12 hours reperfusion. Ind was administered hepatic artery 30 minutes...
To reduce flammability and meet regulatory requirements, Brominated Flame Retardants (BFRs) are added to a wide variety of consumer products including furniture, textiles, electronics, construction materials. Exposure polybrominated phenyl ethers (PBDEs) adversely affects the human health. Bearing in mind that (i) PBDEs potentially toxic, (ii) mechanism PBDE toxicity is unclear, (iii) importance autophagy field toxicology overlooked, this study investigates whether an autophagic process...
Liver regeneration requires an enormous energy supply. Experimental evidence suggests that mitochondrial function is of paramount importance for liver regeneration. However, this has not been investigated in the clinical setting. We aimed to: (i) evaluate changes during hepatectomy, especially after hepatic pedicle clamping; and (ii) correlate these with postoperative hepatocellular outcome.Prospective study thirty patients undergoing hepatectomy. Measurement membrane potential, respiration...
AIM:To investigate the possible involvement of Sirtuin 1 (SIRT1) in rat orthotopic liver transplantation (OLT), when Institute Georges Lopez (IGL-1) preservation solution is enriched with trimetazidine (TMZ). METHODS:Male Sprague-Dawley rats were used as donors and recipients.Livers stored IGL-1 for 8h at 4 ℃, then underwent OLT according to Kamada's cuff technique without arterialization.In another group, livers supplemented TMZ, 10 -6 mol/L, 8 h ℃ OLT.Rats sacrificed 24 after reperfusion,...
Male obesity is associated with decreased testosterone levels but the pathophysiological mechanisms behind this association are not completely understood. This study aimed to investigate impact of hyperglycaemia/insulin resistance and sex hormone-binding globulin (SHBG) on in a population obese men. We investigated several clinical, anthropometric analytic measures 150 males. Testosterone deficiency was present 52.0% enrolled patients. percentage dropped 17.6% when only calculated free (FT)...