A5035424290- Cancer Immunotherapy and Biomarkers
- Nutrition and Health in Aging
- Metabolism, Diabetes, and Cancer
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- Cancer, Lipids, and Metabolism
- Cancer Risks and Factors
- Asthma and respiratory diseases
- RNA modifications and cancer
- Esophageal and GI Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA Research and Splicing
- Radiomics and Machine Learning in Medical Imaging
- Cancer Mechanisms and Therapy
- Cancer, Stress, Anesthesia, and Immune Response
- Pancreatic and Hepatic Oncology Research
- Immune Cell Function and Interaction
- Metastasis and carcinoma case studies
- IL-33, ST2, and ILC Pathways
- Urological Disorders and Treatments
- Biomarkers in Disease Mechanisms
- Lung Cancer Diagnosis and Treatment
Roswell Park Comprehensive Cancer Center
2022-2024
Osmania Medical College
2022
Introduction Survival rates for early-stage non-small cell lung cancer (NSCLC) remain poor despite the decade-long established standard of surgical resection and systemic adjuvant therapy. Realizing this, researchers are exploring novel therapeutic targets deploying neoadjuvant therapies to predict improve clinical pathological outcomes in patients. Neoadjuvant therapy is also increasingly being used downstage disease allow with a curative intent. In this review, we aim summarize current...
Abstract We sought to investigate the association between visceral obesity with disease recurrence and survival in early-stage colorectal cancer (CRC) patients. also wanted examine if such an association, exists, is influenced by metformin use. Stage I/II CRC adenocarcinoma patients treated surgically were identified. L3 level CT VFI (visceral fat index) was used as a metric of calculated proportion total area composed fat. N = 492. 53% males, 90% Caucasians, 35% had stage I disease, 14%...
While obesity measured by body mass index (BMI) has been paradoxically associated with reduced risk and better outcome for lung cancer, recent studies suggest that the harm of becomes apparent when as visceral adiposity. However, prevalence its associations demographic tumor features are not established. We therefore conducted an observational study in 994 non-small cell cancer (NSCLC) patients treated during 2008-2020 at our institution. Routine computerized tomography (CT) images patients,...
Pre-clinical cancer studies ascribe promising anticancer properties to metformin. Yet, clinical findings vary, casting uncertainty on its therapeutic value for non-small cell lung (NSCLC) patients. We hypothesized that metformin could benefit obese and overweight patients with NSCLC.
•We found diverse immune checkpoint co-expression patterns in GEAC.•We showed that elevated PD-L1 expression was linked with increased of other checkpoints.•This supports as a biomarker advanced GEAC for combination immunotherapy.•CD8 T-cell noted different checkpoints, pointing toward potential combined immunotherapy. BackgroundAddition immunotherapy to standard chemotherapy marginally improved outcomes gastroesophageal adenocarcinoma (GEAC). Recently, dual has shown efficacy melanoma and...
Background: Our previous research on neuroendocrine and gastric cancers has shown that patients living in rural areas have worse outcomes than urban patients. This study aimed to investigate the geographic sociodemographic disparities esophageal cancer Methods: We conducted a retrospective between 1975 2016 using Surveillance, Epidemiology, End Results database. Both univariate multivariable analyses were performed evaluate overall survival (OS) disease-specific (DSS) residing (RA) (MA)...
Abstract Background Skeletal muscle indices have been associated with improved peri-operative outcomes after surgical resection of non-small-cell lung cancer (NSCLC). However, it is unclear if these can predict long term specific outcomes. Methods NSCLC patients undergoing lobectomy at our institute between 2009–2015 were included in this analysis ( N = 492). Preoperative CT scans used to quantify skeletal index (SMI) L4 using sliceOmatic software. Cox proportional modelling was performed...
<h3>Background</h3> Potent anti-tumor and immunomodulatory properties have been ascribed to the diabetes drug metformin based on results of myriad preclinical studies.<sup>1–5</sup> However, clinical studies exploring potential benefits this as a cancer therapy inconsistent,<sup>6–12</sup> leaving metformin's therapeutic utility in treatment patients with non-small cell lung (NSCLC) other malignancies doubt. We hypothesized that safe inexpensive can benefit specific clinically significant...
Abstract Dysregulated protein synthesis is seen in many aggressive cancers, including metastatic breast cancer. However, the specific contributions of certain translation initiation factors to vivo disease remain undefined. This particularly true eIF4B, an RNA-binding and cofactor RNA helicase eIF4A associated eIF4F cap-binding complex. While eIF4A, eIF4G, eIF4E are well-known contribute progression cancer types role played by eIF4B remains relatively unclear. We therefore explored how...
308 Background: The role of chemotherapy for patients with early stage, node-negative gastric adenocarcinoma (T2N0M0) remains unclear. Possible options are surgery alone, followed by adjuvant chemotherapy, or perioperative chemotherapy. objective our study was to investigate the and sequence in T2N0M0 adenocarcinoma. Methods: National Cancer Data Base (2006-2017) used identify Patients were categorized into 3 groups, alone (S), (AC), peri-operative (POC). Univariate multivariable Cox...
There exists a gap in understanding the interaction between sex and obesity on tumor microenvironment NSCLC. We demonstrate combined effects of body composition clinically relevant biomarkers NSCLC immune response.
Background Bronchoalveolar lavage (BAL) is an underutilised tool in the search for pulmonary disease biomarkers. While leukocytes with effector and suppressor function play important roles airway immunity tumours, it remains unclear if frequencies phenotypes of BAL can be useful parameters lung cancer studies clinical trials. We therefore explored utility as a source biomarkers interrogating impact smoking, major risk determinant, on immunity. Methods In this “test case” observational study,...
Background: Congenital obstructive nephropathy is the principal cause of end stage renal disease (ESRD) in children ( Beneldet al. 2003). Obstructive leads to Hydronephrosis, dened clinically by an enlargement kidney as a result urine accumulation pelvis or calyces. [1,2] Ureteropelvic junction (UPJ) obstruction most common hydronephrosis with estimated incidence 1 1000–1500 newborns Changet 2004). [2,3] Aims: To evaluate pathogenesis congenital ureteropelvic (UPJO) histopathology, IHC...