A5044062690- Hydrology and Sediment Transport Processes
- Soil erosion and sediment transport
- Hydrology and Watershed Management Studies
- Geological formations and processes
- Cytokine Signaling Pathways and Interactions
- Landslides and related hazards
- interferon and immune responses
- Cancer, Hypoxia, and Metabolism
- Hydraulic flow and structures
- Neonatal Respiratory Health Research
- Heat shock proteins research
- Image Processing and 3D Reconstruction
- Erythropoietin and Anemia Treatment
- Protein Degradation and Inhibitors
- 3D Surveying and Cultural Heritage
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Hydrocarbon exploration and reservoir analysis
- NF-κB Signaling Pathways
- Fish Ecology and Management Studies
- Groundwater flow and contamination studies
- Geophysical Methods and Applications
- Chemical Synthesis and Analysis
- Lipid metabolism and disorders
- Land Rights and Reforms
Federal Institute of Hydrology
2013-2024
AstraZeneca (Sweden)
2019-2023
Morpho (United States)
2022
MRC Protein Phosphorylation and Ubiquitylation Unit
2015-2017
University of Dundee
2015-2017
University of Luxembourg
2009-2011
Optica
2005
Karlsruhe Institute of Technology
1995-2002
Incipient motion of particles on a river bed can, in principle, be understood and predicted from balance the forces acting particles. On natural exposure to flow is variable. The effect initiation motion, including case deep embedding, studied this paper. So far, turbulence‐induced lifting force has been derived exclusively examinations surface flow. understanding destabilization processes riverbed improved when vertical pressure gradients upper sediment layer are included. This particularly...
We have developed the first assays that measure protein kinase activities of interleukin-1 receptor-associated 1 (IRAK1) and IRAK4 reliably in human cell extracts, by employing Pellino1 as a substrate conjunction with specific pharmacological inhibitors IRAK1 IRAK4. exploited these to show was constitutively active its intrinsic activity towards not increased significantly stimulation (IL-1) IL-1R-expressing HEK293 cells, Pam3CSK4-stimulated THP1 monocytes or primary macrophages. Our...
Although porosity is a key property of sediment mixtures, little known the natural variations in fluvial systems. Porosity predictors can help to generate such information. The objective this study was determine accuracy for sand‐gravel mixtures. In order do so, measurements were done Rhine River, using diving bell allow undisturbed sampling under water. addition, laboratory experiments conducted, and data from literature reanalyzed. Measured values range 0.06 0.48. Our shows that based on...
Abstract Sediments contained in the river bed do not necessarily contribute to morphological change. The finest part of sediment mixture often fills pores between larger grains and can be removed without causing a drop level. discrimination pore‐filling load bed‐structure load, therefore, is practical importance for predictions. In this study, new method proposed estimate cut‐off grain size that forms boundary load. evaluates pore structure geometrically. Only detailed grain‐size...
PROteolysis TArgeting Chimeras (PROTACs) targeting the degradation of MEK have been designed based on allosteric inhibitors. Inhibition phosphorylation ERK1/2 was less effective with PROTACs than a small-molecule inhibitor; best PROTACs, however, were more in inhibiting proliferation A375 cells an inhibitor.
The interleukin-6-type cytokine oncostatin M (OSM) acts via the Janus kinase/signal transducer and activator of transcription pathway as well activation mitogen-activated protein kinases is known to critically regulate processes such liver development regeneration, hematopoiesis, angiogenesis, which are also determined by hypoxia with hypoxia-inducible factor 1alpha (HIF1alpha) a key component. Here we show that treatment hepatocytes hepatoma cells OSM leads an increased level HIF1alpha...
Abstract The stability of river channels and their suitability as habitat for aqueous organisms is strongly controlled by the rate bedload transport. Quantification transport rates in rivers difficult, not only because temporal variation transport, but also cross‐channel objectives this study were: (i) to determine effect on uncertainty width‐integrated rates; use knowledge (ii) improve guidelines sampling. This was done through a thorough statistical evaluation stochastic systematic...
Abstract. Suspended sediment is an integral part of riverine transport and functioning that has been strongly altered during the Anthropocene due to overwhelming human pressure on soils, sediments, water cycle. Understanding controls changing suspended in rivers therefore vital for effective management strategies. Here we present results from a trend analysis sediments covering 62 monitoring stations along German waterways (catchment sizes range between 2000 160 000 km2) with more than 440...
The airway epithelium is a major target tissue in respiratory infections, and its antiviral response mainly orchestrated by the interferon regulatory factor-3 (IRF3), which subsequently induces type I (β) III (λ) (IFN) signalling. Dual specificity mitogen-activated protein kinase (MEK) pathway contributes to epithelial defence, but role regulation of IFN human primary cells (AECs) not fully understood. Here, we studied impact small-molecule inhibitor (MEKi) on following challenge with two...
Background: Unlike p38 mitogen-activated protein Kinases (MAPK) that has been extensively studied in the context of lung-associated pathologies COPD, role dual-specificity kinase (MEK1/2) or its downstream signaling molecule extracellular signal-regulated kinases 1/2 (ERK1/2) COPD is poorly understood. Objectives: The aim this study was to address whether MEK1/2 pathway activation linked and targeting can improve lung inflammation through decreased immune-mediated inflammatory responses...
PLK (Polo-like kinase) inhibitors, such as BI-2536, have been reported to suppress IFNB (encoding IFNβ, interferon β) gene transcription induced by ligands that activate TLR3 (Toll-like receptor 3) and TLR4. In the present study, we found BI-2536 is likely exert this effect preventing interaction of factors IRF3 (interferon-regulatory factor c-Jun with promoter, but without affecting TBK1 {TANK [TRAF (tumour-necrosis-factor-receptor-associated factor)-associated nuclear κB activator]-binding...
Abstract Porosity is one of the key properties fluvial sediments. It defined as ratio pore volume to total volume. In river science, porosity often assumed be spatially constant, which might a gross simplification reality. Ignoring spatial variations in can cause errors morphological, ecological, hydrological, hydrogeological and sedimentological applications. Although detailed information about obtained from measurements at field sites, such has never been collected where these important....
Abstract Porosity is one of the key properties dense particle packings like sediment deposits and influenced by a multitude grain characteristics such as their size distribution shape. In present work, we focus on form, specific aspect overall shape, sedimentary grains in order to investigate quantify its effect porosity, ultimately deriving novel porosity-prediction models. To this end, develop robust accurate simulation tool based discrete element method which validate against laboratory...
Depth erosion often occurs along rivers. Erosional tendencies are mainly caused by river training works, course shortenings, flood protection and reduced sediment supply due to dams weirs. Balanced sedimentation, transport processes of utmost importance for the connectivity rivers floodplains as well human water uses. In order classify level bed incision, investigations were carried out case study area Lower Rhine in Germany, Europe's most used waterway, using hydromorphological...
Abstract Existing empirical relations used to predict the porosity of gravel beds are mainly derived from laboratory-generated sediment with random grain packing. However, such could not adequately describe non-random arrangements that occur widely in fluvial deposits. In this work, effect imbrication on gravel-bed has been quantified using variable strengths generated by flume experiments. Mono-sized ellipsoids specific shapes were experiments remove particle size and sorting effects...