A5051386861- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Cancer therapeutics and mechanisms
- Antimicrobial Peptides and Activities
- Bacterial Identification and Susceptibility Testing
- Antimicrobial agents and applications
- RNA and protein synthesis mechanisms
- Pneumonia and Respiratory Infections
- Clostridium difficile and Clostridium perfringens research
- Bacterial Genetics and Biotechnology
- Fungal Infections and Studies
- Bacteriophages and microbial interactions
- Antifungal resistance and susceptibility
- Plant-Microbe Interactions and Immunity
- Peptidase Inhibition and Analysis
- Chemical Synthesis and Analysis
- Gut microbiota and health
- Bacterial biofilms and quorum sensing
- Essential Oils and Antimicrobial Activity
- Microbial Natural Products and Biosynthesis
- DNA Repair Mechanisms
- Enzyme Production and Characterization
- S100 Proteins and Annexins
- Toxin Mechanisms and Immunotoxins
Yeungnam University Medical Center
2024
Handong Global University
2012-2023
Sunlin University
2023
Korea Research Institute of Bioscience and Biotechnology
2006
LG Chem (South Korea)
1996
Oklahoma State University Center for Health Sciences
1994
Seoul National University
1989-1991
University of Wisconsin–Madison
1991
Arctiin, isolated from Forsythia suspensa has been reported to have anti-inflammatory, anti-oxidant, antibacterial, and antiviral effects in vitro. However, there a lack of studies regarding its on immunological activity. The aim this study is investigate the anti-inflammatory potential possible mechanisms arctiin LPS-induced macrophages.We investigated mRNA protein levels proinflammatory cytokines through RT-PCR western blot analysis, followed by FACS analysis for surface molecule...
Journal Article General method for direct cloning of DNA fragments generated by the polymerase chain reaction Get access David Kovalic, Kovalic Pharmacology Department, University Wisconsin Medical SchoolMadison, WI 53706, USA Search other works this author on: Oxford Academic PubMed Google Scholar Jin-Hwan Kwak, Kwak Bernard Weisblum * To whom correspondence should be addressed Nucleic Acids Research, Volume 19, Issue 16, 25 August 1991, Page 4560, https://doi.org/10.1093/nar/19.16.4560...
In recent years, multidrug-resistant (MDR) bacteria have increased rapidly, representing a major threat to human health. This problem has created an urgent need identify alternatives for the treatment of MDR bacteria. The aim this study was antibacterial activity selenium nanoparticles (SeNPs) and nanowires (SeNWs) against assess potential synergistic effects when combined with conventional antibiotic (linezolid). SeNPs SeNWs were characterized by transmission electron microscopy (TEM),...
In traditional oriental medicine, apricot (Prunus armeniaca L.) seed has been used to treat skin diseases such as furuncle, acne vulgaris and dandruff, well coughing, asthma constipation. This study describes the phytochemical profile antimicrobial potential of essential oil obtained from seeds (Armeniacae Semen). The isolated by hydrodistillation was analysed gas chromatography-mass spectroscopy. Benzaldehyde (90.6%), mandelonitrile (5.2%) benzoic acid (4.1%) were identified. Disc...
LCB01-0371 is a new oxazolidinone with cyclic amidrazone. In vitro activity of against 624 clinical isolates was evaluated and compared those linezolid, vancomycin, other antibiotics. showed good Gram-positive pathogens. vivo systemic infections in mice also evaluated. more active than linezolid these infections. bacteriostatic Staphylococcus aureus.
This study was performed to analyse in vitro and vivo activities of CG400549, a new FabI inhibitor, against clinical isolates staphylococci. The mode action CG400549 resistance mechanism Staphylococcus aureus were also investigated by genetic approaches. In activity evaluated the 2-fold agar sdilution method as described CLSI, compared with those oxacillin, erythromycin, ciprofloxacin, sparfloxacin, moxifloxacin, gemifloxacin, vancomycin, linezolid quinupristin-dalfopristin. determined...
ermK instructs bacteria to synthesize an erythromycin-inducible 23S rRNA methylase that confers resistance the macrolide, lincosamide, and streptogramin B antibiotics. Expression of is regulated by transcriptional attenuation, in contrast other inducible erm genes, previously described, which are translationally. The mRNA leader sequence has a total length 357 nucleotides encodes 14-amino-acid peptide together with its ribosome binding site. Additionally, can fold either two mutually...
DW-224a showed the most potent in vitro activity among quinolone compounds tested against clinical isolates of gram-positive bacteria. Against gram-negative bacteria, was slightly less active than other fluoroquinolones. The vivo activities bacteria were more those quinolones.
Polyene macrolides such as nystatin A1 and amphotericin B belong to a large family of very valuable antifungal polyketide compounds typically produced by soil actinomycetes. Recently, nystatin-like Pseudonocardia polyene (NPP) has been identified unique disaccharide-containing tetraene macrolide autotrophica. Despite its significantly increased water solubility decreased hemolytic activity, activity remains limited compared with that A1. In this study, we developed NPP B1, novel derivative...
Virulence factors and biofilms constitute attractive targets for the prevention of infections caused by multidrug-resistant bacteria. Among alkyl gallates, propyl gallate (PG) octyl (OG) are used as food preservatives. Here we found that gallates differentially affect virulence, biofilm formation, quorum sensing (QS) in Pseudomonas aeruginosa. Ethyl (EG), PG, butyl (BG) inhibited formation virulence including elastase, pyocyanin, rhamnolipid, P. aeruginosa without affecting cell viability...
Multidrug-resistant (MDR) bacteria are increasing due to the abuse and misuse of antibiotics, nosocomial infections by MDR also increasing. The aim this study was identify new substances that can target among 12 plant extracts known have antibacterial effects. experiments were performed disk diffusion test microdilution minimum inhibitory concentration (MIC) test, as described Clinical Laboratory Standards Institute (CLSI). By screening against methicillin-sensitive Staphylococcus aureus...
Abstract Calcineurin modulates environmental stress survival and virulence of the human fungal pathogen Cryptococcus neoformans. Previously, we identified 44 putative calcineurin substrates, proposed that pathway is branched to regulate targets including Crz1, Pbp1, Puf4 in C. In this study, characterized Had1, which one substrates belonging ubiquitously conserved haloacid dehalogenase β-phosphoglucomutase protein superfamily. Growth had1∆ mutant was found be compromised at 38° or higher....
Zabofloxacin is a novel fluoroquinolone agent that has potent activity against gram-positive pathogens. In this study, we confirmed zabofloxacin showed the most in vitro and vivo activities drug-resistant Streptococcus pneumoniae. Among compounds, clinical isolates of penicillin-sensitive S. pneumoniae (minimum inhibitory concentration, MIC90: 0.03 mg/L) penicillin-resistant (MIC90: mg/L). Against quinolone-resistant pneumoniae, 1 was more active than ciprofloxacin, sparfloxacin,...
Thiopeptides exhibit potent antimicrobial activity against Gram-positive pathogens by inhibiting bacterial protein synthesis. Micrococcins are among the structurally simpler thiopeptides, but they have not been exploited in detail. This research involved a computational simulation of micrococcin P2 (MP2) docking parallel with structure-activity relationship (SAR) studied. The incorporation particular nitrogen heterocycles side chain MP2 enhances activity. Micrococcin analogues 6c and 6d thus...
Obesity is a major global health problem which associated with various diseases and psychological conditions. Increasing understanding of the relationship between obesity gut microbiota has led to worldwide effort use as treatment for obesity. However, several clinical trials have shown that single strains probiotics did not achieve significant results in animal studies. To overcome this limitation, we attempted find new combination goes beyond effects alone by combining natural substance...
The cop-rep region of plasmid pE194 contains two tandem structural genes, cop and repF, as well the plus minus origins replication. genes comprise an operon whose expression is repressed by binding Cop protein to a 28-bp inverted complementary repeat sequence that overlaps cop-repF promoter. From its position relative promoter experimentally determined footprint made protein, presumed function operator. intercistronic between repF 80 nucleotides (nt) long transcribed bidirectionally: in...