A5102731495- Mathematical Dynamics and Fractals
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Chromatography in Natural Products
- Chaos control and synchronization
- Immune Cell Function and Interaction
- Computability, Logic, AI Algorithms
- Plant-Microbe Interactions and Immunity
- T-cell and B-cell Immunology
- Respiratory viral infections research
- Gene Regulatory Network Analysis
- Autoimmune and Inflammatory Disorders Research
- Microscopic Colitis
- Atherosclerosis and Cardiovascular Diseases
- Plant Pathogenic Bacteria Studies
- Clostridium difficile and Clostridium perfringens research
- Neonatal Respiratory Health Research
- Advanced Mathematical Theories and Applications
- Advanced Topology and Set Theory
- Systemic Lupus Erythematosus Research
- Fractal and DNA sequence analysis
- Urinary Tract Infections Management
- Inflammatory Biomarkers in Disease Prognosis
- Cellular Mechanics and Interactions
- Polysaccharides and Plant Cell Walls
Institute of Food Science and Technology
2024
Nanjing Agricultural University
2024
Ministry of Agriculture and Rural Affairs
2024
Chinese Academy of Agricultural Sciences
2024
Fudan University
2015-2023
State Key Laboratory of Oncogene and Related Genes
2019-2023
Renji Hospital
2019-2023
Shanghai Cancer Institute
2019-2023
Huadong Hospital
2023
Hansoh Pharma (China)
2023
The claudin 18.2 (CLDN18.2) antigen is frequently expressed in malignant tumors, including pancreatic ductal adenocarcinoma (PDAC). Although CLDN18.2-targeted CAR-T cells demonstrated some therapeutic efficacy PDAC patients, further improvement needed. One of the major obstacles might be abundant cancer-associated fibroblasts (CAFs) tumor microenvironment (TME). Targeting fibroblast activation protein (FAP), a vital characteristic CAFs provides potential way to overcome this obstacle. In...
Abstract Purpose: T-cell recruitment, survival, and proliferation are the important limitations to chimeric antigen receptor (CAR) T cells therapy in treatment of solid tumors. In this study, we engineered CAR-T coexpress cytokines IL7 CCL21 (7 × 21 CAR-T), a cytokine combination order improve chemotaxis cells. Experimental Design: CLDN18.2-specific second-generation coexpressing were prepared using retroviral vector transduction. The migration genetically evaluated vitro. antitumor...
3017 Background: B7-H3, a member of the B7 superfamily, is highly expressed in various solid tumors, but has limited expression at low level normal tissues. HS-20093 B7-H3-targeted antibody-drug conjugate. It could be an attractive therapeutic option for advanced especially patients (pts) who have failed multi-line therapy requiring novel and more effective treatment. Methods: This first-in-human, multicenter, open-label phase 1 study tumors (NCT05276609). Dose escalation part assessed...
Abstract Septins as GTPases in the cytoskeleton, are linked to a broad spectrum of cellular functions, including cell migration and progression hepatocellular carcinoma (HCC). However, roles SEPT11, new member septin, have been hardly understood HCC. In study, clinical significance biological function SEPT11 HCC was explored. screened out by combining ATAC-seq with mRNA-seq. Role further investigated using overexpression, shRNA CRISPR/Cas9-mediated SEPT11-knockout cells or vivo models. We...
Inflammatory responses play decisive roles in tumor development, immune surveillance, and to therapy. High neutrophil-to-lymphocyte ratio (NLR), as an inflammation index, has been reported be a predictor for poor prognosis of various cancers. The purpose this meta-analysis was evaluate the prognostic value NLR patients with rectal cancer.A comprehensive search literature conducted through PubMed EMBASE. Pooled hazard (HR) 95% confidence interval (CI) used association between three outcomes:...
IL12 is an immune-stimulatory cytokine for key immune cells including T and NK cells. However, systemic administration of has serious side effects that limit its clinical application in patients. Recently, synthetic Notch (synNotch) receptors have been developed induce transcriptional activation deliver therapeutic payloads response to the reorganization specific antigens. NK92 cell a human natural killer (NK) line which as tools adjuvant immunotherapy cancer. Here, we explored possibility...
We prove that when $f$ is a continuous self-map acting on compact metric space $(X,d)$ satisfies the shadowing property, then set of irregular points (i.e., with divergent Birkhoff averages) has full entropy. Using this fact, we that, in class $C^{0}$ -generic maps manifolds, can only observe (in sense Lebesgue measure) convergent averages. In particular, time average atomic measures along orbits such converges to some Sinai–Ruelle–Bowen-like measure weak $^{\ast }$ topology. Moreover, carry...
Chimeric antigen receptor (CAR) T cells targeting glypican-3 (GPC3) demonstrated early signs of therapeutic efficacy to hepatocellular carcinoma patients with a risk cytokine release syndrome (CRS). Several adoptive cell therapies (ACTs) using the natural (TCR) signaling induced more efficient antitumor function and reduced production relative CARs in solid tumors. To improve safety GPC3-targeted ACTs, were modified anti-GPC3 single-chain fragment variable(sFv) linked CD3ε, which could be...
// Yi-Wei Dong 1, * , Yan-Qiang Shi Li-Wen He 1 Xi-Yu Cui 2 and Pei-Zhu Su The Second Clinical Medical School of Southern University, Guangzhou 510282, Guangdong, China Department Gastroenterology, First People's Hospital Foshan (Affiliated Sun Yat-sen University), 528000, These authors have contributed equally to this work should be considered as co-first Correspondence to: Cui, email: cuixiyufoshan@126.com Su, supeizhu1986@163.com Keywords: pancreatic neoplasms, metformin, prognosis,...
Paired amphipathic helix protein (SIN3B) is a transcription corepressor for many genes. Here we show different regulation mechanism of integrin αV gene expression by SIN3B in human hepatocellular carcinoma (HCC). We first observed close relationship between Integrin and expressions HCC patients tumor cell lines with metastatic potentials. Overexpression significantly accelerated the migration rate SMMC-7721, but failed when was silenced. Interestingly, stimulated subunit promoter activity...
Objective: Analyze the changes of indicator antimicrobial usage and detection rate multidrug-resistant gram-negative bacteria (MDR-GNB), in order to evaluate impact stewardship program (ASP). Methods: The was implemented since December 2011 at Second Affiliated Hospital Yuying Children's Wenzhou Medical University. Intensified effort made from 2014 2017. We divided into four stages, one before ASP (2010-2011) three after (2012-2013 as first, 2014-2015 second 2016-2017 third post-ASP stages)....
LIHC (liver hepatocellular carcinoma) mostly occurs in patients with chronic liver disease. It is primarily induced by a vicious cycle of injury, inflammation, and regeneration that usually last for decades. The G protein nucleolar 2 (GNL2), as protein-encoding gene, also known NGP1, Nog2, Nug2, Ngp-1, HUMAUANTIG. Few reports are shown towards the specific biological function GNL2. Meanwhile, it still unclear whether related to pathogenesis carcinoma up date. Here, our study attempts...
By an appropriate definition, we divide the irregular set into level sets. Then characterize multifractal spectrum of these new pieces by calculating their entropies. We also compute entropies various intersections sets regular and which is rarely studied in literature. Moreover, our conclusions hold for topological pressure. Finally, consider continuous case use results to give a description suspension flow.
It is shown that there exist systems having almost specification property and zero entropy. Since Bowen has with must have positive entropy, this result reveals further the difference between specification. Moreover, one can obtain a both sufficient necessary condition to ensure entropy for property.
Abstract β-1,6-Glucan plays a crucial role in fungal cell walls by linking the outer layer of mannoproteins and inner β-1,3-glucan, contributing significantly to maintenance wall rigidity. Therefore, hydrolysis β-1,6-glucan β-1,6-glucanase directly leads disintegration wall. Here, novel Fl Glu30 was identified from endophytic Flavobacterium sp. NAU1659 heterologously expressed Escherichia coli BL21 (DE3). The optimal reaction conditions purified were 50℃ pH 6.0, resulting specific activity...
We prove that when $f$ is a continuous selfmap acting on compact metric space $(X,d)$ which satisfies the shadowing property, then set of irregular points (i.e. with divergent Birkhoff averages) has full entropy. Using this fact we in class $C^0$-generic maps manifolds, can only observe (in sense Lebesgue measure) convergant averages. In particular, time average atomic measures along orbit such converges to some SRB-like measure weak$^*$ topology. Moreover, carry zero contrast, are...
In this paper, we explore a topological system $f:M\rightarrow M$ with average shadowing property. We extend Sigmund's results and show that every non-empty, compact connected subset $V\subseteq\mathcal {M}_{inv}(f)$ coincides $V_f(y)$, where $\mathcal denotes the space of invariant Borel probability measures on M, $V_f(y)$ accumulation set time Dirac supported at orbit $y$. also $M_{V}=\{y\in M\,\,|\,\,V_{f}(y)=V\}$ is dense in $Δ_{V}=\bigcup_{ν\in V}supp(ν)$. particular, if...