The aim of this study was to evidence trends and changes in mortality, comorbid conditions, prognosis, causes death after 5 years continuous evolution hemodialysis (HD) patients Romania.We included two cohorts stable HD (901 from 2012 1396 2017). Both were followed up for 1 year. 5-year survivors the cohort identified 2017 their data assessed.The older, with longer time on dialysis, higher serum creatinine urea levels, required ultrafiltration volume per dialysis. They also had lower...

Introduction: Contrast-induced nephropathy (CIN) has emerged as a prevalent and serious complication associated with the administration of iodinated contrast media during diagnostic therapeutic procedures. Given rising global prevalence chronic kidney disease(CKD,) it is crucial to gain deeper understanding risks linked exposure. Therefore, aim this study, conducted at Vascular Surgery Clinic in tertiary hospital Eastern Europe (Timisoara, Romania), assess incidence CIN identify its risk...

Background: Childhood obesity has seen an important rise in recent decades, both the pediatric and adult populations. Excess weight can cause various health complications, such as metabolic syndrome (MetS), a cluster of medical conditions linked to adverse cardiometabolic outcomes. Although MetS may be attributed mainly adults, early life factors, birth characteristics feeding practices, influence its development obese children. Aim: This study aims investigate relationships between metrics,...

Background/Objectives: Urinary tract infections (UTI) represent a global problem with implications for mortality and morbidity. Published data present different bacterial incidences antibiotic resistance. The objective of our study is to evaluate the bacteria distribution in positive urine cultures mixed adult population differences resistance in- outpatients. Methods: We analyzed 1186 2021 from Emergency County Hospital “Pius Brinzeu” Timisoara, Romania. evaluated stratified by outpatients...

Introduction Kidney dysfunction is prevalent in oncology patients and has an impact on their treatment quality of life. The aim our study was to analyze the prevalence CKD a large cohort several types cancer East European Region. Material methods We conducted observational retrospective 5831 consecutive, biopsy-diagnosed between January 2019 –December 2020 largest hospital outpatient clinic Western Romania. 4342 subjects were included statistical analysis. Results discussion From 24 types,...

Klotho is found in two forms: a transmembrane form and soluble (s-Klotho). In order to be excreted, s-Klotho, that too large filtered, will probably reach the proximal convoluted tubule by transcytosis process. The aim of our study was show relationship between levels s-Klotho tubular injury patients with diabetic kidney disease (DKD), using as marker molecule-1 (KIM-1).Our included 63 DKD (stages 1-5, mean eGFR 65.15±32.45ml/min) age 58.13±12 years. all we determined serum of: KIM-1 ELISA,...

End-stage kidney disease patients (ESKD) receiving hemodialysis (HD) are at a greater risk of hepatitis virus (HV) infections due to the invasive nature procedures, frequent hospital stays and surgeries, as well immune deficiency status ESKD.This study was reassess prevalence in HD population Romania after 5 years oral DAAs therapy assess impact on patients' outcomes two cohorts (2015 2019).We compared ESKD treated with 10 centers from historical regions 2015 (n = 1401, Mean age 59.7 ± 12.92...

The primary objective was to determine the epidemiologic influence of AKI awareness among physicians in a mixt paediatric population, including neonates. This single-centre, multiyear, observational retrospective study included all admitted patients between first July 2014 and 31 December 2021. identified 2194 out 128,036 hospital admissions with 129,936 serum creatinine measurements. Matching comparisons were used aware non-aware patients. overall incidence 1.65%. Stage 1 24.24% cases,...

Background: Acute kidney disease (AKD) is a known risk factor for increased mortality and evolution towards chronic (CKD) in adults. The data regarding children are scarce. purpose of our study to explore the AKD impact following an acute injury (AKI) episode on new-onset CKD. Methods: We retrospectively evaluated 736 with ages between 2 18 years old AKI admitted tertiary care hospital from west Romania over 9 period. Results: incidence was 17%. Patients that developed were older, higher...

Chronic kidney disease patients treated by hemodialysis present a high cardio-vascular morbidity and mortality. There is an imperative need for novel biomarkers in identifying to offer possible therapeutically intervention these patients. We performed prospective observational cohort study on 77 the period October 2021 – 2023. measured serum plasma levels of Interleukin 1-Beta, Galectin 3, human suppression tumorigenicity factor 2, bone morphogenetic protein 2 fibroblastic growth...

The increase in bacterial resistance is currently a global burden for the health care system. In order to evaluate rates of several bacteria from most encountered cultures clinical practice, we performed retrospective analysis all positive year 2021 tertiary hospital Romania. Our captured 3299 cultures. median age patients was 62 years (IQR: 41-71 old) with slight predominance among females (53.1%). Overall, common were urocultures, wound secretion and blood cultures, identified

Spinal muscular atrophy (SMA), identified over a century ago, is characterized by severe muscle wasting and early mortality. Despite its rarity, the high carrier frequency of responsible genetic mutations variability in manifestations make it significant research focus. This prospective cross-sectional descriptive study evaluated health-related quality life (HRQoL) across eight health domains 43 Romanian SMA patients treated with nusinersen, using SF-36 questionnaire to analyze influencing...

Background: Changing the term/concept of non-alcoholic fatty liver disease (NAFLD) to metabolic dysfunction associated (MAFLD) may broaden pathological definition that can include chronic renal involvement, and, possibly, changes kidney disease's (CKD's) epidemiological association with disease, because CKD is disorders and almost all patients present some form an atherogenic dyslipidemia. Our study explores relationship between MAFLD using Transient Elastography (TE) a Controlled Attenuated...

Klotho is found in two forms: a transmembrane form and soluble (s-Klotho). In order to be excreted, s-Klotho, that too large filtered, will probably reach the proximal convoluted tubule by transcytosis process. The aim of our study was show relationship between levels s-Klotho tubular injury patients with diabetic kidney disease (DKD), using as marker molecule-1 (KIM-1). Our included 63 DKD (stages 1–5, mean eGFR 65.15 ± 32.45 ml/min) age 58.13 12 years. all we determined serum of: KIM-1...

Kinetic estimation of glomerular filtration rate (KeGFR) has proved its utility in predicting acute kidney injury (AKI) both adults and children. Our objective is to assess the clinical KeGFR AKI severity progression disease (AKD) patients already diagnosed with examine major adverse events at 30 days (MAKE30). We retrospectively calculated within first 24 h identified (KeGFR1) prior AKD (KeGFR2) all admitted children under 18 years old. The cohort consisted 803 AKI. proposed a new...

Abstract Left ventricular (LV) structure and function anomalies are frequent during the CKD continuum associated with increased risk of mortality. Cross section longitudinal ultrasound data available for advanced transition to ESKD. Less information is about LV changes stable, long-term hemodialysis (HD) treatment. All stable HD patients from 9 centers (1034 patients, 671 males, age 58.71 ± 12.94 years) have been enrolled in January 2015. The cohort was followed-up 4 years, kidney...

Chronic kidney disease patients treated by hemodialysis present a high cardiovascular morbidity and mortality. There is an imperative need for novel biomarkers identifying these to offer possible therapeutically interventions. We performed prospective observational cohort study on 77 in the period of October 2021–October 2023. measured serum plasma levels interleukin 1-beta, galectin 3, human suppression tumorigenicity factor 2, bone morphogenetic protein 2 fibroblastic growth 23 at...

<title>Abstract</title> <bold>Background:</bold> Acute kidney injury (nAKI) is common in neonates with increased mortality and hospitalization. Less known about the creatinine dynamics outside acute impact on survival new-borns first week of life. <bold>Methods:</bold> We performed an observational, retrospective, single-centre study admitted to “Louis Turcanu” Emergency County Hospital for Children between 2014 2022. The cohort consisted 1106 serum values recorded day life at least another...

Background: Acute kidney disease (AKD) is a known risk factor for increased mortality and evolution towards chronic (CKD) in adults. The data regarding AKD children are scarce. purpose of our study was to explore the factors developing based on exposures susceptibilities with AKI doubled by biological parameters from first day identified AKI. In addition, we followed trajectory following an acute injury (AKI) episode during hospital admission after discharge special considerations...

Background: Diagnosis and treatment for pharyngeal cancer are decisive in determining prognosis. delays frequent, representing a significant cause of avoidable mortality, an important factor subpar survival across the continuous HNC care delivery. Methods: The present study represents retrospective analysis medical records from Western Romania, which included 180 patients, to evaluate impact time-to-treatment delay on patients diagnosed with cancer. data analyses were performed using...

Background/Objectives: Urinary tract infections represent a global problem with implications on mortality and morbidity. Published data present different bacterial incidence antibiotics resistances. With this study, we aimed to evaluate bacteria distribution antibiotic resistance in tertiary care hospital from the Western part of Romania. Methods: evaluated all positive urine culture year 2021 Emergency County Hospital “Pius Brinzeu” Timisoara, We 1264 cultures identified following bacteria:...

Acute kidney injury (AKI) is common in neonates with increased mortality and longer hospitalization. Few studies have evaluated AKI outcomes relation to serum creatinine dynamics from the first day of life.

Abstract Background and Aims Neoplasia is considered a risk factor for the development of CKD, many reasons: aggressive repeated therapeutic interventions, malnutrition, hyperuricemia disease per se. Taking into account improved cancer survival due to novel possibility patients with CKD reach advanced stages increasing. The information about still scarce. This paper tends fill gap by analyzing relation between in large database from western Romania. Method 5831 (3365 female, average age 62.6...