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Cristina Lumbreras-Perales

ORCID: 0000-0003-3671-1093
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About
Contact & Profiles
A5106902238
Research Areas
  • Connective Tissue Growth Factor Research
  • Cerebrovascular and genetic disorders
  • Intracerebral and Subarachnoid Hemorrhage Research

University of Glasgow
 2024

 Collagen IV deficiency causes hypertrophic remodeling and endothelium-dependent hyperpolarization in small vessel disease with intracerebral hemorrhage
OPENALEX - Publications 
Sarah McNeilly Cameron R. Thomson Laura Gonzalez-Trueba Yuan Yan Sin Alessandra Granata and 24 more Graham Hamilton Michelle Lee Erin Boland John McClure Cristina Lumbreras-Perales Alisha Aman Apoorva A. Kumar Marco Cantini Çağlar Gök Delyth Graham Yasuko Tomono Christopher D. Anderson Yinhui Lu Colin Smith Hugh S. Markus Marc Abramowicz Catheline Vilain Rustam Al‐Shahi Salman Manuel Salmerón‐Sánchez Atticus H. Hainsworth William Fuller Karl E. Kadler Neil J. Bulleid Tom Van Agtmael

Genetic variants in COL4A1 and COL4A2 (encoding collagen IV alpha chain 1/2) occur genetic sporadic forms of cerebral small vessel disease (CSVD), a leading cause stroke, dementia intracerebral haemorrhage (ICH). However, the molecular mechanisms CSVD with ICH COL4A1/COL4A2 remain obscure. Vascular function investigations mice Col4a1 missense mutation heterozygous Col4a2 knock-out were combined analysis human brain endothelial cells harboring mutations, tissue patients ICH. mutations...

10.1016/j.ebiom.2024.105315 article EN cc-by EBioMedicine 2024-08-30
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