A5085187222- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Estrogen and related hormone effects
- Neurological Disorders and Treatments
- Histone Deacetylase Inhibitors Research
- Menopause: Health Impacts and Treatments
- Epigenetics and DNA Methylation
- Intracranial Aneurysms: Treatment and Complications
- Cancer-related cognitive impairment studies
- Drug Transport and Resistance Mechanisms
- FOXO transcription factor regulation
- Pancreatic and Hepatic Oncology Research
- Memory and Neural Mechanisms
- Educational and Social Studies
- Folate and B Vitamins Research
- Epilepsy research and treatment
- Acute Ischemic Stroke Management
- Spatial Neglect and Hemispheric Dysfunction
- Medical Imaging Techniques and Applications
- Neurogenesis and neuroplasticity mechanisms
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
2021-2025
University of Udine
2004-2015
Centro San Giovanni di Dio Fatebenefratelli
2000-2010
Istituti di Ricovero e Cura a Carattere Scientifico
2000-2009
Université Laval
2009
Cognitive Neuroimaging Lab
2003-2007
University of California, Los Angeles
2007
Italian Institute of Telemedicine
2006
Clinical observations have suggested that the neuropsychological profile of early and late onset forms Alzheimer's disease (EOAD LOAD) differ in neocortical functions are more affected former learning latter, suggesting they might be different diseases. The aim this study is to assess brain structural basis these observations, test whether areas heavily EOAD medial temporal LOAD. Fifteen patients with 15 LOAD (onset before after age 65; Mini Mental State Examination 19.8, SD 4.0 20.7, 4.2)...
To test the applicability of an automated method magnetic resonance image analysis (voxel based morphometry) to detect presence and severity regional grey matter density reduction-a proxy atrophy-in Alzheimer's disease.Twenty nine probable patients 26 non-demented controls (mini-mental state examinations mean (SD) 21 (4) 29 (1)) underwent high resolution 3D brain imaging. Spatial normalisation a stereotactic template, segmentation into matter, white cerebrospinal fluid, smoothing were...
<b>Objective:</b> To examine the brain structural correlates of age at onset in patients with Alzheimer’s disease. <b>Methods:</b> We studied nine early (age ⩽65 years), late >65) disease (EOAD and LOAD, respectively) mild-moderate severity, 26 controls who were stratified into younger (YC, ⩽65, n = 9) older (OC, >65, 17) subjects. The closely matched for clinical severity: 3/2/3/1 had dementia rating 0.5/1/2/3, respectively, both groups. High resolution magnetic resonance images EOAD...
Abstract Purpose To compare the accuracy of voxel‐based morphometry (VBM) and region interest (ROI)‐based hippocampal volumetry to detect medial temporal lobe atrophy in Alzheimer's disease (AD). Materials Methods A total 27 AD patients (age 74 ± 9 years; 22 women; Mini‐Mental State Exam [MMSE] 21 4) 25 controls 70 8; 16 MMSE 29 1) were studied. Accuracy VBM gray matter loss those seven 11 with similar ROI‐based measures four five VBM‐based was assessed. performed statistical parametric...
Pancreatic ductal adenocarcinoma (PDAC) represents an unmet clinical need due to the very poor prognosis and lack of effective therapy. Here we investigated potential domatinostat (4SC-202), a new class I histone deacetylase (HDAC) inhibitor, currently in development, sensitize PDAC first line standard gemcitabine (G)/taxol (T) doublet chemotherapy treatment.Synergistic anti-tumor effect combined treatment was assessed PANC1, ASPC1 PANC28 cell lines vitro as well on tumor spheroids...
The diagnosis of mild cognitive impairment (MCI) is clinically unhelpful, as many patients with MCI develop dementia but do not.To identify clinical instruments easily applicable in the routine that might be useful to predict progression assessed outpatient facility a memory clinic.52 dementia-free (mean (standard deviation) age 70 (6) years; 56% women) MCI, and 65 healthy controls (age 69 54% underwent brain magnetic resonance scan standardised visual assessment medial temporal atrophy...
In Brief Objective: Estrogens are known to be protective in age-associated cognitive changes humans and neurodegeneration animal models. The aim of this study was evaluate the potential effects estrogen therapy (ET) on human gray matter volume vivo. Design: Forty healthy postmenopausal women underwent three-dimensional high-resolution magnetic resonance imaging: 17 were never treated, 16 currently receiving ET, 7 had ET past. Voxel-based morphometry (VBM) with SPM2 used, according an...
We describe an Italian pedigree with hereditary dementia associated a novel T122R mutation in the presenilin-2 gene (PSEN2). The clinical history, symptom presentation, and structural neuroimaging were consistent atypical form of dementia. Disease expression varied within family members. One pair mutated monozygotic twins had evident signs disease, whereas other did not, even if her functional investigations, cerebrospinal fluid levels Abeta1-42, Tau protein able to provide markers for...
Abstract Purpose To investigate the possible effect of APOE ϵ4 allele on age‐related regional volume loss within corpus callosum (CC) in healthy carriers compared with noncarriers. Materials and Methods A total 211 subjects, ages 27 to 83 years, 51 160 noncarriers underwent T1‐weighted MRI scan. All subjects had normal scan performed range a neuropsychological battery tests. CC was segmented into seven functionally relevant regions using previously published probabilistic map connectivity....
<i>Aim:</i> To describe the clinical and neuropsychological features of mild cognitive impairment (MCI) patients with medial temporal atrophy (MTA), white matter hyperintensities (WMH), both, neither to assess whether rate progression differs among groups. <i>Methods:</i> Ninety-five MCI were divided into 4 groups based on presence MTA WMH: 29 MTA– WMH–, 11 WMH+, 23 MTA+ 32 WMH+. compared 30 normal subjects. WMH assessed MR-based visual rating scales. Subjects...