A5046511626- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- RNA modifications and cancer
- Bladder and Urothelial Cancer Treatments
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Genetics and Neurodevelopmental Disorders
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Toxin Mechanisms and Immunotoxins
- Hereditary Neurological Disorders
- Genetic Associations and Epidemiology
- MicroRNA in disease regulation
- Parvovirus B19 Infection Studies
- Genomics and Chromatin Dynamics
- Endometriosis Research and Treatment
- Obsessive-Compulsive Spectrum Disorders
- Adolescent and Pediatric Healthcare
- Eating Disorders and Behaviors
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Sperm and Testicular Function
- Reproductive System and Pregnancy
- Hippo pathway signaling and YAP/TAZ
- Prenatal Screening and Diagnostics
Mohammed Bin Rashid University of Medicine and Health Sciences
2023-2024
Nationwide Children's Hospital
2024
Tehran University of Medical Sciences
2018-2022
Long non-coding RNAs (lncRNAs) and exosomes have been regarded as components of cell signal transmission that modulate indigenous cellular microenvironments. Exosomes also participate in relocation functional lncRNAs between cells.In the present study, we evaluated expression LINC00355, LINC00958, UCA1-201, UCA1-203, MALAT1 urinary isolated from transitional carcinoma (TCC) bladder, non-malignant disorders, normal subjects.LINC00355, was significantly higher TCC patients compared to controls...
Background: Exosomes have been regarded as emerging tools for cancer diagnosis. Tumor-derived exosomes contain molecules that enhance progression and affect immune responses. Material methods: In the present study, we evaluated expression of seven cancer-testis antigens (CTAs) are putative biomarkers immunotherapeutic targets along with NMP22 in urinary bladder patients, healthy subjects patients affected nonmalignant disorders. Results: Exosomal MAGE-B4 was significantly higher compared...
Abstract A major revelation of genome-scale biological studies in the post-genomic era has been that two-thirds human genes do not encode proteins. The majority non-coding RNA transcripts humans are long (lncRNA) molecules, non-protein-coding regulatory with sizes greater than 500 nucleotides. LncRNAs involved nearly every aspect cellular physiology, playing fundamental roles both normal cells and disease. As result, they functionally linked to multiple diseases, from cancer autoimmune,...
Abstract Schizophrenia is a severe, disabling psychiatric disorder with unclear etiology. Family-based, twins, and adoption studies have shown that genetic factors major contributions in schizophrenia occurrence. Until now, many discovered the association of its comorbid symptoms functional polymorphisms lie within serotonin reuptake pathway genes. Here, we aimed to investigate three variable number tandem repeats (VNTR) MAOA SLC6A4 Iranian population. Two hundred forty-one subjects seventy...
Endometrial receptivity plays a key role in pregnancy success assisted reproduction cycles. Recent evidence suggests that seminal plasma (SP) and follicular fluid (FF) influence the uterine endometrium to improve implantation of embryo establishment pregnancy. In this study, we attempt assess FF SP on expression levels main endometrial genes (HOXA10, HOXA11, ITGAV, ITGB3 LIF) stromal cells.In experimental were collected from 15 healthy fertile men women, respectively. Tissue specimens...
Abstract Background Glycogen storage disease (GSD) is a rare inborn error of the synthesis or degradation glycogen metabolism. GSD1, most common type GSD, categorized into GSD1a and GSD1b which caused by deficiency glucose-6-phosphatase ( G6PC ) glucose-6-phosphate transporter SLC37A4 ), respectively. The high rates consanguineous marriages in Iran provide desirable context to facilitate finding homozygous pathogenic mutations. This study designates evaluate clinical genetic characteristics...
Aim: Cancer-testis antigens (CTAs) have specific expression in gametogenic tissues and aberrant cancers. Materials & methods: We assessed of five testis-specific genes namely KIF2B, CST8, TMEM225, RBM46, OAZ3 bladder cancer tissues, adjacent non-neoplastic urinary cell pellets (UCPs) patients compared with nonmalignant conditions.Results: Expressions all CTAs were higher UCPs conditions. RBM46 was recurrent tumors primary without hematuria those having hematuria. TMEM225 tumoral high-grade...
OBJECTIVES: To evaluate the performance of current national screening policy for Down syndrome (DS) in Iran and suggest a more efficient protocol with wealth large series first-trimester (FTS) data obtained from Nilou medical laboratory. fulfill this aim, detection rate (DR), positive (PSR), false negative (FNR) odds being affected given results (OAPR) were calculated at different cutoff risk. In latest update DS program Iran, there is no place intermediate group to be further investigated....