A5033797544- Peripheral Neuropathies and Disorders
- Hereditary Neurological Disorders
- IgG4-Related and Inflammatory Diseases
- Vasculitis and related conditions
- Neuroendocrine Tumor Research Advances
- Botulinum Toxin and Related Neurological Disorders
- Urticaria and Related Conditions
- Eosinophilic Disorders and Syndromes
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Peripheral Nerve Disorders
- Cancer and Skin Lesions
- Cancer-related Molecular Pathways
- Autoimmune Neurological Disorders and Treatments
- Ophthalmology and Eye Disorders
- Neurofibromatosis and Schwannoma Cases
- Drug-Induced Ocular Toxicity
- Genetic Neurodegenerative Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Antibiotics Pharmacokinetics and Efficacy
- Infectious Encephalopathies and Encephalitis
- Cerebrovascular and genetic disorders
- Gastroesophageal reflux and treatments
- Folate and B Vitamins Research
- Congenital gastrointestinal and neural anomalies
- Body Composition Measurement Techniques
Toyohashi Municipal Hospital
2018-2022
Okazaki City Hospital
2020-2022
Nagoya University
2013-2020
Nagoya City University Hospital
2020
Maastricht University
2017
Yokohama City University
2015
Japanese Red Cross Nagoya Daini Hospital
2013
Acute flaccid myelitis (AFM) is an acute paralysis syndrome with spinal motor neuron involvement of unknown etiology. We investigated the characteristics and prognostic factors AFM clusters coincident enterovirus D68 (EV-D68) outbreak in Japan during autumn 2015.
To investigate the clinicopathologic features of eosinophilic granulomatosis with polyangiitis (EGPA)-associated neuropathy a focus on presence or absence anti-neutrophil cytoplasmic antibodies (ANCAs).We examined clinical and pathologic findings sural nerve biopsy specimens from 82 patients EGPA-associated neuropathy. Of these patients, 32.9% were myeloperoxidase (MPO)-ANCA positive, 67.1% MPO-ANCA negative. PR3-ANCA was negative in all 78 patients.Upper limb symptoms more frequently...
The clinical significance and characteristics of neuropathy caused by folate deficiency remain to be established.We examined the clinicopathologic features 18 consecutive patients with who presented low serum levels but normal blood thiamine cobalamin in absence chronic alcoholism.Symptoms were relatively uniform, characterized slowly progressive polyneuropathy predominant involvement lower extremities, a tendency manifest as sensory rather than motor deep superficial loss....
Importance:The newly recognized entity IgG4related disease (IgG4-RD) is characterized by an elevated IgG4 serum concentration and tissue infiltration IgG4-positive plasma cells.We describe, for the first time, clinical features nerve biopsy findings of a patient with IgG4-RD who presented neuropathy in extremities.Observations: A 55-year-old man had histopathologically defined that manifested as sensorymotor neuropathy.The neuropathic were multiple mononeuropathies electrophysiological...
To evaluate the pathologic significance of immunoglobulin G4 (IgG4) in patients with inflammatory peripheral neuropathy.We clinicopathologically examined 149 consecutive neuropathy who had clusters cells or without vasculitis sural nerve biopsy specimens and whom we were able to assess serum IgG4 levels.Elevation levels infiltration IgG4-positive plasma cells, which are currently defined as diagnostic criteria for IgG4-related disease, found 35 29 patients, respectively. In 44 exhibiting...
We herein report a case of peripheral neuropathy following exposure to large amounts glyphosate-based herbicide. A 70-year-old man suffered from pain and purpura in the left sole Pain spread opposite side increased severity. Mild weakness lower limbs was also observed. sural nerve biopsy revealed infiltration lymphocytes around small vessels epineurium with numerous eosinophils, deposition hemosiderins focal axonal degeneration, compatible findings vasculitic neuropathy. Glyphosate-based...
Background and purpose Muscle atrophy is generally mild in patients with chronic inflammatory demyelinating polyneuropathy ( CIDP ) compared the severity duration of muscle weakness. was evaluated using computed tomography CT . Methods Thirty‐one typical who satisfied diagnostic criteria for definite classification proposed by European Federation Neurological Societies Peripheral Nerve Society were assessed. The clinicopathological findings also those without atrophy. Results Computed...
Aceruloplasminemia is an autosomal recessive inherited disorder caused by ceruloplasmin gene mutations. The loss of ferroxidase activity due to mutations causes a disturbance in cellular iron transport. We herein describe patient with aceruloplasminemia, who presented diabetes mellitus that was treated insulin injections, liver hemosiderosis phlebotomy therapy, and neurological impairment. A genetic analysis the revealed novel compound heterozygous c.1286_1290insTATAC exon 7 c.2185delC 12....
To elucidate the significance of uncompacted myelin lamellae (UML) and ion channel disruption at nodes Ranvier in polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes (POEMS) syndrome, we evaluated sural nerve biopsy specimens from 33 patients with POEMS syndrome 7 control patients. Uncompacted distribution was assessed by electron microscopy immunofluorescence microscopy. In patient biopsies, UML were seen more frequently small versus large myelinated fibers....
Abstract To clarify the pathogenesis of anti-myelin-associated glycoprotein (MAG) antibody neuropathy associated with IgM monoclonal gammopathy (anti-MAG neuropathy), sural nerve biopsy specimens from 15 patients were investigated. Sodium channels, potassium contactin-associated protein 1 (Caspr1), contactin 1, and neurofascin evaluated by immunofluorescence in teased-fiber preparations. Immunoreactivity to pan-sodium channel both anti-MAG normal controls was concentrated at node Ranvier...
We herein report the case of a patient with pancreatic cancer who manifested features chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and autoimmune hemolytic anemia (AIHA). A 78-year-old Japanese man presented AIHA was treated steroids splenectomy. Although improved following splenectomy, suffered from sensorimotor neuropathy soon after undergoing surgery. The electrophysiological indicated neuropathy. refractory to immunomodulatory treatment, intensive investigations...
To elucidate the significance of uncompacted myelin lamellae (UML) and ion channel disruption at nodes Ranvier in polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes (POEMS) syndrome, we evaluated sural nerve biopsy specimens from 33 patients with POEMS syndrome 7 control patients. Uncompacted distribution was assessed by electron microscopy immunofluorescence microscopy. In patient biopsies, UML were seen more frequently small versus large myelinated fibers....
Eosinophilic granulomatosis with polyangiitis (EGPA) is one of the principal causes vasculitic neuropathy.1 Recently, clinicopathologic differences among patients EGPA based on their antineutrophil cytoplasmic antibody (ANCA) status have been reported.1–3 Furthermore, efficacy mepolizumab (an anti-interleukin-5 [IL-5] drug) for treatment has demonstrated.4 IL-5 a cytokine that essential eosinophil proliferation, maturation, differentiation,4–6 and survival.3 Although considered to be closely...
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by reactivation JC virus under an immunosuppressed state. This condition carries high risk cryptococcal meningitis. We herein report 65-year-old woman who simultaneously developed PML and meningitis presented with bilateral sixth nerve palsy. She had been treated methotrexate infliximab for rheumatoid arthritis. Her symptoms improved antifungal drug treatment discontinuation...
Acute autonomic sensory and motor neuropathy (AASMN) is characterized by prominent dysautonomia with somatic impartment. Prominent observed during the early phase of AASMN. We herein describe a case AASMN that involved prolonged failure disturbance sensation despite rapid recovery from weakness. The delayed heart-to-mediastinum ratios on 123I-meta-iodobenzylguanidine myocardial scintigraphy were decreased improved within seven months. However, orthostatic hypotension was prolonged. These...
Mowat-Wilson syndrome (MWS) is a rare genetic disorder characterized by intellectual disability, distinctive facial features, epilepsy, and multiple anomalies caused heterozygous loss-of-function mutations in the zinc finger E-box-binding homeobox-2 gene (ZEB2). Treatment choice very important as patients with MWS because sometimes develop drug-resistant epilepsy. Here, we report case of 45-year-old male patient who developed status epilepticus after 26-years seizure-free period while taking...