A5101627495- Parkinson's Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Organ and Tissue Transplantation Research
- Ginkgo biloba and Cashew Applications
- Neurological disorders and treatments
- Nuclear Receptors and Signaling
- Neurogenetic and Muscular Disorders Research
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Cannabis and Cannabinoid Research
- Autophagy in Disease and Therapy
- Diet and metabolism studies
- Medicinal Plants and Neuroprotection
- Biochemical Analysis and Sensing Techniques
- Natural product bioactivities and synthesis
- Berberine and alkaloids research
- Phytochemistry and Biological Activities
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Poisoning and overdose treatments
- Neuroscience and Neuropharmacology Research
- Plant Toxicity and Pharmacological Properties
- Drug-Induced Hepatotoxicity and Protection
Universidade Federal da Bahia
2017-2024
National Council for Scientific and Technological Development
2023
Universidade Salvador
2023
Universidad de Murcia
2021
Centro de Ingeniería Genética y Biotecnología
1992
Recent evidence shows that aminochrome induces glial activation related to neuroinflammation. This dopamine derived molecule formation and stabilization of alpha-synuclein oligomers, mitochondria dysfunction, oxidative stress, dysfunction proteasomal lysosomal systems, endoplasmic reticulum stress disruption the microtubule network, but until now there has been no effects on production cytokines neurotrophic factors, are mechanisms involved in neuronal loss Parkinson's disease (PD). study...
Recent discoveries have shown that enteric glial cells play an important role in different neurodegenerative disorders, such as Parkinson’s disease (PD), which is characterized by motor dysfunctions caused the progressive loss of dopaminergic neurons substance nigra pars compacta and non-motor symptoms including gastrointestinal dysfunction. In this study, we investigated modulatory effects flavonoid rutin on behavior myenteric plexuses a PD animal model response glia. Adult male Wistar rats...
Agathisflavone, purified from Cenostigma pyramidale (Tul.) has been shown to be neuroprotective in vitro models of glutamate-induced excitotoxicity and inflammatory damage. However, the potential role microglial regulation by agathisflavone these effects is unclear. Here we investigated microglia submitted stimulus view elucidating mechanisms neuroprotection. Microglia isolated cortices newborn Wistar rats were exposed Escherichia coli lipopolysaccharide (LPS, 1 µg/mL) treated or not with (1...
Prosopis juliflora is a shrub that has been used to feed animals and humans. However, synergistic action of piperidine alkaloids suggested be responsible for neurotoxic damage observed in animals. We investigated the involvement programmed cell death (PCD) autophagy on mechanism induced by total extract (TAE) fraction (F32) from P. leaves composed majoritary juliprosopine model neuron/glial co-culture. saw TAE (30 µg/mL) F32 (7.5 reduction ATP levels changes mitochondrial membrane potential...
Recent discoveries have shown that enteric glial cells play an important role in different neurodegenerative disorders such as Parkinson's disease (PD), which is characterized by motor dysfunctions caused progressive loss of dopaminergic neurons the substance nigra pars compacta and non-motor symptoms including gastrointestinal dysfunction. In this study we observed modulatory effects flavonoid rutin on glia a PD animal model. Adult male Wistar rats were submitted to stereotaxic...
This article has no abstract.
From 1987 to the present our Cuban Centre has performed more than 30 foetal nigral transplants striatum in patients with Parkinson’s disease. To study improvement reported dopaminergic drug response and decrease L-Dopa daily dose together better motor performance /1/, pharmacological trial was applied four Parkinsonian patients, who underwent stereotactic implantations of ventral mesencephalon dissociated cells. Four male idiopathic disease were studied during their hospitalization...