A5062624148- Livestock and Poultry Management
- Genetic and phenotypic traits in livestock
- Animal Nutrition and Physiology
- Genomics and Phylogenetic Studies
- Genetic diversity and population structure
- Microbial infections and disease research
- RNA and protein synthesis mechanisms
- Bacteriophages and microbial interactions
- Livestock Farming and Management
- Virology and Viral Diseases
- Animal Diversity and Health Studies
- Silkworms and Sericulture Research
- Wildlife Ecology and Conservation
- Species Distribution and Climate Change
- Rangeland Management and Livestock Ecology
Roslin Institute
2023-2025
University of Edinburgh
2023-2025
University of Nottingham
2020-2022
Abstract Breeding for climate resilience is currently an important goal sustainable livestock production. Local adaptations exhibited by indigenous allow investigating the genetic control of this resilience. Ecological niche modeling (ENM) provides a powerful avenue to identify main environmental drivers selection. Here, we applied integrative approach combining ENM with genome-wide selection signature analyses (XPEHH and Fst) genotype−environment association (redundancy analysis), aim...
This study supports the development of predictive bacteriophage (phage) therapy: concept phage cocktail selection to treat a bacterial infection based on machine learning (ML) models. For this purpose, ML models were trained thousands measured interactions between panel and sequenced isolates. The was applied Escherichia coli associated with urinary tract infections. is an important common in humans companion animals from which multidrug-resistant (MDR) bloodstream infections can originate....
Abstract Identifying genomic regions under selection is crucial for comprehending the evolutionary history of domestic chicken. Arabian Peninsula (AP) indigenous chickens are mostly found outdoors, being reared alongside other livestock production purposes. These birds show high resilience to extreme temperatures (hot and cold), typical desert environment. The pressures responsible unique local adaptations in these remain largely unidentified. Here, we aimed investigate genome diversity...
The Tigray region, where we found around eight per cent of the indigenous cattle population Ethiopia, is considered as historic centre country, with ancient pre-Aksumite and Aksumite civilisations in contact Fertile Crescent Indian subcontinent. Here, used whole genome sequencing data to characterise genomic diversity, relatedness, admixture five populations (Abergelle, Arado, Begait, Erob, Raya) region Ethiopia. We detected 28 29 million SNPs 2.7 2.9 indels each population, which 7% 34%...
Poultry play an important role in the agriculture of many African countries. The majority chickens sub-Saharan Africa are indigenous, raised villages under semi-scavenging conditions. Vaccinations and biosecurity measures rarely apply, infectious diseases remain a major cause mortality reduced productivity. Genomic selection for disease resistance offers potentially sustainable solution but this requires sufficient numbers individual birds with genomic phenotypic data, which is often...
Abstract Indigenous chickens predominate poultry production in Africa. Although preferred for backyard farming because of their adaptability to harsh tropical environments, these populations suffer from relatively low productivity compared commercial lines. Genome analyses can unravel the genetic potential improvement birds both and resilience traits benefit African systems. Here we report whole-genome sequences 234 indigenous 24 Ethiopian distributed under diverse agro-climatic conditions....
In evolutionary ecology, an “ecotype” is a population that genetically adapted to specific environmental conditions. Environmental and genetic characterisation of livestock ecotypes can play crucial role in conservation breeding improvement, particularly achieve climate resilience. However, are often arbitrarily defined without detailed their agro-ecologies. this study, we employ novel integrated approach, combining ecological niche modelling (ENM) with genomics, delineate based on habitats...
The Tigray region is an ancient entry route for the domestic chickens into Africa. oldest African chicken bones were found in this at Mezber, a pre-Aksumite rural farming settlement. They dated to around 800-400 BCE. Since then, communities of have integrated their livelihoods. also recognised its high chicken-to-human population ratio and diverse complex geography, ranging from 500 4,000 m above sea level (m.a.s.l.). More than 15 agro-ecological zones been described. Following exotic...
Abstract Bangladeshi indigenous chicken varieties - Common Deshi, Hilly and Naked Neck are notable for their egg production, meat quality, extraordinary survivability disease resistance. However, the potential to harness unique genetic merits being eroded by various factors, including crossbreeding. In-depth genomic studies have not been carried out on these breeds so far. To this end, blood samples associated phenotypic metadata collected from local, unimproved birds sampled 8 different...
Identifying genomic regions under selection is crucial for comprehending the evolutionary history of domestic chicken. The Arabian Peninsula (AP) indigenous chickens are mostly found outdoors, being reared alongside other livestock production purposes. These birds show high resilience to extreme temperatures (hot and cold), typical desert environment. pressures responsible unique local adaptations in these remain largely unidentified. Here, we aimed investigate genome diversity structure...
Abstract In evolutionary ecology, an ecotype is a population that genetically adapted to specific environmental conditions. Environmental and genetic characterisation of livestock ecotypes can play crucial role in conservation breeding improvement, particularly achieve climate resilience. However, are often arbitrarily defined without detailed their agro-ecologies. this study, we employ novel integrated approach, combining Ecological Niche Modelling (ENM) with genomics, delineate based on...
Abstract This study supports the development of predictive bacteriophage (phage) therapy: concept phage cocktail selection to treat a bacterial infection based on machine learning models (MLM). For this purpose, MLM were trained thousands measured interactions between panel and sequenced isolates. The was applied Escherichia coli ( E. ) associated with urinary tract infections. is an important common in humans companion animals from which multi-drug resistant (MDR) bloodstream infections can...