A5103195417- Developmental Biology and Gene Regulation
- Pluripotent Stem Cells Research
- Single-cell and spatial transcriptomics
- Medicinal Plant Research
- Angiogenesis and VEGF in Cancer
- Retinal Development and Disorders
- Retinal and Optic Conditions
- Gene Regulatory Network Analysis
- Congenital heart defects research
- Mechanisms of cancer metastasis
- Cellular Mechanics and Interactions
- CRISPR and Genetic Engineering
- Polysaccharides Composition and Applications
- Circadian rhythm and melatonin
- Histone Deacetylase Inhibitors Research
- DNA and Biological Computing
- Chemical and Physical Studies
Institute of Genomics and Integrative Biology
2024
Fortis Memorial Research Institute
2024
Spanish National Centre for Cardiovascular Research
2017-2019
Utah State University
2005-2007
Abstract Appropriate therapeutic modulation of endothelial proliferation and sprouting is essential for the effective inhibition angiogenesis in cancer or its induction cardiovascular disease. The current view that an increase growth factor concentration, resulting mitogenic activity, increases both sprouting. Here, we modulate stimuli different vascular contexts by interfering with function VEGF Notch signalling pathways at high spatiotemporal resolution vivo. Contrary to prevailing view,...
Improved methods for manipulating and analyzing gene function have provided a better understanding of how genes work during organ development disease. Inducible functional genetic mosaics can be extraordinarily useful in the study biological systems; however, this experimental approach is still rarely used vertebrates. This mainly due to technical difficulties assembly large DNA constructs carrying multiple regulatory elements their targeting genome. In addition, mosaic phenotypic analysis,...
Abstract Background A significant body of literature is devoted to modeling developmental mechanisms that create patterns within groups initially equivalent embryonic cells. Although it clear these do not function in isolation, the timing and interactions between during embryogenesis well known. In this work, a computational approach was taken understand how lateral inhibition, differential adhesion programmed cell death can interact mosaic pattern biologically realistic primary secondary...
Objective: Present work focuses on the use of mimosa seed gum to develop a drug delivery system making combined floating and pulsatile principles, for chrono-prevention nocturnal acid breakthrough. Methodology: The desired aim was achieved by fabricating bearing time – lagged coating Mimosa pudica polymer programmed release Famotidine. Response Surface Methodology statistical tool that employed experiment designing, mathematical model generation optimization study. A 32 full factorial design...
Present work focuses on the use of tamarind gum to develop a drug delivery system making combined floating and pulsatile principles, for chrono-prevention nocturnal acid breakthrough.The desired aim was achieved by fabricating bearing time - lagged coating Tamarindus indica seed polymer programmed release Famotidine. Response Surface METHODology statistical tool that employed experiment designing, mathematical model generation optimization study. A 32 full factorial design used in designing...