To evaluate the long-term efficacy of bevacizumab for treatment chronic diffuse diabetic macular edema after various previous treatments.A total 126 patients (mean age: 66 years) with were consecutively incorporated in this prospective, noncomparative case series. Inclusion was performed independently from size edema, retinal thickness, visual acuity (VA), age, metabolic control, type diabetes, or treatments. The underwent a complete eye examination including best-corrected VA ETDRS charts,...

We assessed differences in compliance and adherence (lateness of patients, visual acuity, reasons for abstaining) between patients with diabetic macular edema (DME) age-related degeneration (AMD), both under anti-vascular endothelial growth factor therapy.We included 136 DME (36% women, 65 years, 22 visits, 13.9 injections, 29.9 months follow-up) 109 AMD (59% 76 20 14.7 22.3 (minimum follow-up 12 at least 5 injections). missed appointments >14 days) therapy break-offs >100 days). All delayed...

Abstract Purpose The aim of this study was to evaluate the influence internal limiting membrane (ILM) peeling on repair proliferative vitreoretinopathy grade B (PVR B) primary rhegmatogenous retinal detachment (RRD). Methods Thirteen consecutive eyes that underwent pars plana vitrectomy (ppV) with ILM for PVR (group 1) were matched a cohort 13 RRD without and 2). Minimum follow-up 6 months, all operated by same surgeon. Preoperative characteristics (age, lens status, macula-ON/OFF) similar...

To evaluate the effect of intravitreal bevacizumab (Avastin; Genentech, Inc., South San Francisco, CA) injections on visual acuity and foveal retinal thickness in patients with central vein occlusion (CRVO).In this prospective, noncomparative, consecutive, interventional case series, 46 received repeated (1.25 mg) bevacizumab. Main outcome measures were (Snellen ETDRS charts) optical coherence tomography measurements a 6-month follow-up period.Mean improved from 20/250 at baseline to 20/80...

<h3>Purpose:</h3> To evaluate the effect of intravitreal bevacizumab (Avastin) injections on visual acuity (VA) and foveal retinal thickness in patients with macular oedema secondary to branch vein occlusion. <h3>Methods:</h3> A prospective, non-comparative, consecutive, interventional case series 34 patients. Patients received repeated 1.25 mg bevacizumab. Main outcome measures were VA (Snellen charts ETDRS) (optical coherence tomography measurements) a follow-up period 6 months....

To assess the reactive changes of corneal epithelial thickness (ET) profile induced by small incision lenticule extraction (SMILE) for treatment myopia.This prospective observational study included 46 eyes 23 patients that were scheduled myopic SMILE. High-resolution spectral-domain optical coherence tomography (SD-OCT) and a custom image segmentation algorithm applied to measure ET at multiple time points within central 5-mm zone. Postoperative alterations correlated with parameters...

Purpose To compare the efficacy of a computer-assisted marker system for toric intraocular lenses (IOLs) (Callisto Eye System) with manual marking techniques. Setting University Hospital Munich, Ludwig-Maximilians-University, Germany. Design Prospective case series. Methods This study included patients having cataract surgery implantation IOL (Torbi 709 M). They were randomly assigned to 1 2 groups based on used, or digital. Patients if they had age-related and regular corneal astigmatism...

To correlate the incidence of postoperative endophthalmitis with changes in preoperative prophylaxis over a 20-year period.Department Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.Retrospective chart review.Patients diagnosed from 1990 to 2009 after intraocular surgery performed at same institution were included. Because during study period, 3 groups formed for data analysis: Period 1 (1990 1992), no standardized regimen; period 2 (1993 1998), topical medication,...

Purpose.: In early exudative age-related macular degeneration (AMD), segmental thinning of Bruch's membrane is associated with ingrowth choroidal neovascularization into the subretinal space. To determine whether there a link between oxidative stress and extracellular matrix (ECM) degradation by retinal pigment epithelium, present study focused on effect MMP-1 MMP-3 expression, two enzymes substrate specificity for components membrane. Methods.: Cultured human RPE cells were exposed to...

Aim of this study was to evaluate the efficacy switching treatment faricimab in neovascular age-related macular degeneration (nAMD) from other anti-VEGF agents. Fifty-eight eyes fifty-one patients with nAMD and a full upload series four injections were included. Demographic data, multimodal imaging parameters recorded. The primary outcome measures changes central subfield thickness (CST) subfoveal choroidal (SFCT). A subgroup analysis performed for prior ranibizumab (R) or aflibercept (A)...

To implant a small-aperture intraocular lens (IOL) (IC-8) in eyes with severe corneal irregularities to reduce higher-order aberrations and provide better central visual acuity.University Hospital, LMU Munich, Germany.Prospective nonrandomized interventional case series.Eyes due keratoconus, previous penetrating keratoplasty, status postradial keratotomy, or scarring after ocular trauma were enrolled. Exclusion criteria progressive pseudoexfoliation, glaucoma, maculopathy, reduced...

To evaluate the repeatability and validity of total corneal power measurements (total keratometry [TK]) obtained with a recently introduced optical biometer (IOLMaster 700, Carl Zeiss Meditec AG) to Scheimpflug device (Pentacam, Oculus).

To investigate the effectiveness and safety of a dexamethasone implant (Ozurdex) to treat pseudophakic macular edema (Irvine-Gass syndrome).Department Ophthalmology, Ludwig-Maximilians-University Munich, Germany.Prospective nonrandomized study.Preoperatively in 12 monthly postoperative intervals, complete ophthalmic examination was performed study patients, including measurement corrected distance visual acuity (CDVA) using standard Early Treatment Diabetic Retinopathy Study chart,...

Epithelial-to-mesenchymal transition (EMT) of retinal pigment epithelial cells is a crucial event in the onset proliferative vitreoretinopathy (PVR), most common reason for treatment failure detachment surgery. We studied alterations cell surface glycan expression profile upon EMT RPE and focused on its relevance interaction with galectin-3 (Gal-3), carbohydrate binding protein, which can inhibit attachment spreading human dose- carbohydrate-dependent manner, thus bares potential to...

Purpose To compare the safety and efficacy between femtosecond laser–assisted cataract surgery using Victus laser system conventional surgery. Setting Department of Ophthalmology, Kepler University Hospital, Linz, Austria. Design Prospective randomized case series. Methods Both eyes patients with age-related were to or surgery, both intraocular lens (IOL) implantation. Postoperative follow-up was at 1 day, week, month, 3 months, 6 months comprised corrected distance visual acuity,...

Purpose To prospectively characterize the stromal thickness changes during first year after myopic small-incision lenticule extraction using spectral-domain optical coherence tomography (SD-OCT). Setting Department of Ophthalmology, Kepler University Hospital, Linz, Austria. Design Prospective case series. Methods This study evaluated eyes that had to treat myopia or astigmatism. A high-resolution SD-OCT system (RS 3000 Advance) in conjunction with a custom image-segmentation algorithm was...

Abstract Sub-retinal fluid (SRF) has been discussed as a protective factor against macular atrophy in eyes with neovascular age-related degeneration (nAMD).To gauge the impact of SRF on atrophy, database 310 nAMD was screened for manifesting an SRF-only phenotype under treat &amp; extend anti-VEGF treatment, defined expressing CNV exudation beyond three monthly loading doses by only without any signs exudative intra-retinal (IRF) ≥3 years. Incidence and treatment responses were evaluated...

To evaluate the outcomes of myopic small incision lenticule extraction (SMILE) monovision in presbyopic patients.This study included 49 patients older than 45 years seeking surgical correction myopia or astigmatism who underwent bilateral SMILE with planned Eyes Clinic Linz, Austria. Target refraction was plano for dominant (distance) eyes and ranged between -1.25 -0.50 D nondominant (near) eyes. Best-corrected distance visual acuity, uncorrected acuity (UDVA), near as well spectacle...

Purpose To assess the clinical outcomes and patient satisfaction after bilateral cataract surgery with implantation of a bifocal refractive enhanced depth focus intraocular lens (IOL) low near addition (add). Setting Department Ophthalmology, Ludwig-Maximilians-University Munich, Germany. Design Prospective longitudinal case series. Methods Eyes age-related corneal astigmatism less than 1.0 diopter (D) had standard microincision nondiffractive shape-segmented IOL (Lentis Comfort, LS-313...

Purpose: To assess the efficacy and outcomes of 23-gauge vitreoretinal surgery for rhegmatogenous retinal detachment using a three-dimensional heads-up display (3D HUD) surgical platform as compared to standard operating microscope (SOM) setting. Design: Retrospective cohort study. Participants: One hundred forty consecutive eyes 140 patients with primary detachment. Methods: All underwent pars plana vitrectomy either 3D HUD (NGENUITY; Alcon Inc., Fort Worth, Texas, USA; n = 70 eyes) or SOM...

Small incision lenticule extraction (SMILE), with over 5 million procedures globally performed, will challenge ophthalmologists in the foreseeable future accurate intraocular lens power calculations an ageing population. After more than one decade since introduction of SMILE, only case report cataract surgery IOL implantation after SMILE is present peer-reviewed literature. Hence, scope multicenter study was to compare calculation accuracy post-SMILE eyes between ray tracing and a range...

To characterize patient-reported long-term quality of vision (QoV) after small-incision lenticule extraction (SMILE), and to identify potential clinical parameters that might predispose experiencing deteriorated visual quality.University Eye Hospital, Ludwig-Maximilians-University, Munich, Germany.Prospective cross-sectional study.For the assessment scoring symptoms, Quality Vision questionnaire was employed, which constitutes a clinically validated, linear-scaled 30-item instrument...