A5029279483- Digestive system and related health
- Animal Genetics and Reproduction
- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- RNA and protein synthesis mechanisms
- Gene expression and cancer classification
- CRISPR and Genetic Engineering
- BRCA gene mutations in cancer
- Genetic Mapping and Diversity in Plants and Animals
- DNA Repair Mechanisms
- Hemoglobinopathies and Related Disorders
- Cancer-related molecular mechanisms research
- Infections and bacterial resistance
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Chromosomal and Genetic Variations
- Genomics and Phylogenetic Studies
- Antibiotic Resistance in Bacteria
- Plant Pathogenic Bacteria Studies
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Blood groups and transfusion
- Genetic factors in colorectal cancer
- Iron Metabolism and Disorders
The University of Texas at Dallas
2022-2024
Center for Systems Biology
2022-2024
University of Macau
2019-2020
Xcellon School of Business
2015
BRCA1 and BRCA2 play essential roles in maintaining the genome stability. Pathogenic germline mutations these two genes disrupt their function, lead to instability increase risk of developing breast ovarian cancers. BRCA have been extensively screened Caucasian populations, resulting information are used globally as standard reference clinical diagnosis, treatment prevention BRCA-related Recent studies suggest that can be ethnic-specific, raising question whether a Caucasian-based mutation...
Background Pathogenic variation in BRCA1 and BRCA2 ( BRCA ) is one of the most frequent genetic predispositions for hereditary breast cancer. The identification variant carriers plays an important role prevention treatment Despite a population size 1.4 billion quarter million annual new cancer cases, knowledge regarding prevalence Chinese remains elusive. Methods In this study, we used -targeted sequencing bioinformatics approaches to screen variants 11 386 Han individuals, including 9331...
The three-dimensional genome organization influences diverse nuclear processes. Here we present Chromatin Interaction Predictor (ChIPr), a suite of regression models based on deep neural networks, random forest, and gradient boosting to predict cohesin-mediated chromatin interaction strength between any two loci in the genome. predictions ChIPr correlate well with ChIA-PET data four cell lines. standard model requires three experimental inputs: ChIP-Seq signals for RAD21, H3K27ac, H3K27me3...
PurposeDNA mismatch repair (MMR) genes play important roles in maintaining genome stability. Mutations MMR disrupt their function, cause instability and lead to increased risk of cancer the mutation carriers as represented by Lynch Syndrome. Studies have identified a large number variants, mostly Caucasian population, whereas data from non-Caucasian populations remain poorly illustrated. With population size 1.4 billion, knowledge variants Chinese can be valuable understanding ethnic...
We report the draft genome of Brevundimonas diminuta strain XGC1, isolated from a tuberculosis-infected patient in Gujarat, India. This study also reveals that B. XGC1 has acquired mutation to confer resistance quinolone drugs.
Abstract Background Core promoter controls transcription initiation. However, little is known for core diversity in the human genome and its relationship with diseases. We hypothesized that as a functional important component genome, could be under evolutionary selection, reflected by highly diversification order to adjust gene expression better adaptation different environment. Results Applying “Exome-based Variant Detection Core-promoters” method, we analyzed core-promoter using 2682 exome...
About 200 causative mutations are characterized in the β-globin gene. Beta thalassemia diagnosis is very complicated due to genetic diversity of HBB gene across different geographical regions world. In present study, we have analyzed 138 clinical specimens among them 66 were from 21 unrelated families (trio samples which had DNA father, mother and chorionic villus sample/amniotic fluid sample) 72 individual using newly developed sequencing PCR based assay. We observed 11 samples, also cited...
ABSTRACT The three-dimensional (3D) genome organization influences diverse nuclear processes. Chromatin interaction analysis by paired-end tag sequencing (ChIA-PET) and Hi-C are powerful methods to study the 3D organization. However, ChIA-PET experiments expensive, time-consuming, require tens hundreds of millions cells, challenging optimize analyze. Predicting ChIA-PET/Hi-C data using cheaper ChIP-Seq other easily obtainable features could be a useful alternative. It is well-established...
Abstract The three-dimensional (3D) genome organization influences diverse nuclear processes. Chromatin interaction analysis by paired-end tag sequencing (ChIA-PET) and High-throughput chromatin conformation capture (Hi-C) are powerful methods used to study the 3D organization. However, these two experiments costly, time-consuming, require tens hundreds of millions cells, challenging optimize analyze. Predicting ChIA-PET/Hi-C data using cheaper ChIP-Seq other easily obtainable features is a...