A5102381643- Atherosclerosis and Cardiovascular Diseases
- Glycosylation and Glycoproteins Research
- Structural Engineering and Vibration Analysis
- Cellular Mechanics and Interactions
- Endoplasmic Reticulum Stress and Disease
- Health and Wellbeing Research
- RNA Interference and Gene Delivery
- Biochemical Analysis and Sensing Techniques
- Microtubule and mitosis dynamics
- DNA and Nucleic Acid Chemistry
- RNA modifications and cancer
- Cardiac Fibrosis and Remodeling
- Sphingolipid Metabolism and Signaling
- Advanced biosensing and bioanalysis techniques
- Cancer-related gene regulation
- Cancer survivorship and care
- Pancreatic function and diabetes
- Traditional Chinese Medicine Studies
- Cardiomyopathy and Myosin Studies
- Salivary Gland Disorders and Functions
- Signaling Pathways in Disease
- Endometrial and Cervical Cancer Treatments
Chinese Academy of Sciences
2025
Capital Medical University
2023-2025
University of Chinese Academy of Sciences
2021-2025
Beijing Tongren Hospital
2023
Zhejiang Cancer Hospital
2021
Aviation General Hospital
2020
Beijing National Laboratory for Molecular Sciences
2016
Peking University
2016
Stanford University
2012
Under endoplasmic reticulum (ER) stress (ERS), cells initiate the unfolded protein response (UPR) to maintain ER homeostasis. Recent studies revealed ERS transmission between and tissues, by activating cell-nonautonomous UPR in that do not experience directly. Here, we report triggers a rapid release of ceramide independent UPR, but requiring acid sphingomyelinase activity. Carried lipoproteins, is delivered receiving induce regulate cell functions at multiple aspects, including lipid...
Women with breast cancer are more prone to bone loss, joint pain, and other musculoskeletal symptoms, especially those receiving aromatase inhibitors and/or undergoing ovarian suppression therapy. Bone problems can affect their quality of life treatment adherence. Thus, the management health is clinical importance for this population. This study aimed systematically develop a multicomponent intervention women assess acceptability program. The Rebuilding Osteo Strength Exercise (ROSE) program...
Background Acute myocardial infarction (AMI) is one of the leading causes death worldwide. The etiology AMI complex and has not been fully defined. In recent years, role immune response in development, progression prognosis received increasing attention. aim this study was to identify key genes associated with analyze their infiltration. Methods included a total two GEO databases, containing 83 patients 54 healthy individuals. We used linear model microarray data (limma) package find...
Esophageal squamous cell carcinoma (ESCC), a major form of esophageal cancer, is serious threat to human health. This study was conducted investigate the pathogenesis ESCC and find effective therapies improve it. Protein expression transfected plasmids detected by RT-qPCR western blot. Co-immunoprecipitation assay performed verify binding LETM1 KIF14. CCK-8, wound healing transwell assays were used assess proliferation, invasion migration cells. Finally, angiogenesis assessed using tubule...
Objective: The objective of this study was to observe the effect Bushen Qingre Yuyin Decoction on spleen index, submandibular gland salivary secretion, morphology, and aquaporin 5 (AQP5) expression levels in gland. Materials Methods: Fifty 8-week-old nonobese diabetic (NOD) female mice were randomly divided into following five groups: model; hydroxychloroquine; high-, medium-, low-dose prescription. blank group consisted ten Balb/C rats. administered by gavage at 20, 40, 80 g/kg low-,...
In our country, buildings are facing the severe threat of earthquake disaster, almost all have to carry out structural seismic design.Shear wall structure is one common systems high-rise building, in order study isolation effect high aspect ratio and understand reason effect, under action horizontal force, Timushenko beam can assume deformation mode bending-shear type, which close characteristics shear structure.The bottom has lateral displacement curve strong earthquake, its mechanical...