A5080071332- Nonlinear Optical Materials Research
- Advanced Drug Delivery Systems
- Cytokine Signaling Pathways and Interactions
- Synthesis and biological activity
- Advancements in Transdermal Drug Delivery
- SARS-CoV-2 and COVID-19 Research
- Synthesis and Characterization of Heterocyclic Compounds
- Essential Oils and Antimicrobial Activity
- Drug-Induced Hepatotoxicity and Protection
- Nanoparticles: synthesis and applications
- Free Radicals and Antioxidants
- Drug Solubulity and Delivery Systems
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical and Antibiotic Environmental Impacts
- Graphene research and applications
- Pharmacological Effects of Natural Compounds
- Graphene and Nanomaterials Applications
- Nanoparticle-Based Drug Delivery
- Rheumatoid Arthritis Research and Therapies
- Curcumin's Biomedical Applications
- Crystallization and Solubility Studies
- Photochemistry and Electron Transfer Studies
- Genomics, phytochemicals, and oxidative stress
- Computational Drug Discovery Methods
- Advanced Photocatalysis Techniques
King Saud University
2021-2025
Jamia Millia Islamia
2009-2018
Department of Biotechnology
2016-2018
Background: In the current study, we evaluated therapeutic potential of sinapic acid (SA) in terms mechanism underlying its gastroprotective action against ethanol-induced gastric ulcers rats. Methods: These effects were examined through gross macroscopic evaluation stomach cavity [gastric ulcer index (GUI)], alteration pH, juice volume, free acidity, total wall mucus, and changes PGE2. addition, lipid peroxidation (malondialdehyde), antioxidant systems (catalase glutathione), inflammatory...
: Ulcerative colitis (UC) is a long-term condition which results in inflammation and ulcers of the colon rectum. The key indications active disease are abdominal pain diarrhea mixed with blood.
Experimental and theoretical investigations were made on the molecule 3,4-dichloro-1,2,5-thiadiazole abbreviated as DCTDA. Density functional theory (DFT) approach with B3LYP was employed for calculations. Geometrical optimization is performed under DFT's MP2 method basis set 6-311++ G (d, p) which entire computational study (Molecular Electrostatic Potential [MEP], Electron localization function [ELF], Natural bond orbital [NBO], Non-Linear optical [NLO], Temperature dependent DFT [TD-DFT]...
Using quantum chemical calculations, spectroscopic methods, and molecular docking analysis, this work explores the electronic, structural, vibrational, biological characteristics of CAFI. Intramolecular hydrogen bonding between methyl C = O groups (with bond lengths less than 3 Å) was detected, affirming stability. Corresponded with theoretical expectations, FT-IR UV spectra corroborating CAFI's Frontier orbital study indicated HOMO-LUMO energy gaps 4.227 eV (gas) 4.792 (ethanol),...
Rheumatoid arthritis (RA) is a chronic inflammatory disease mainly affecting the synovial joints. A highly potent antagonist of C-C chemokine receptor 5 (CCR5), maraviroc (MVC), plays an essential role in treating several infectious diseases but has not yet been evaluated for its potential effects on RA development. This study focused evaluating therapeutic MVC collagen-induced (CIA) DBA/1J mice. Following CIA induction, animals were treated intraperitoneally with (50 mg/kg) daily from day...
Hyperglycemia and hyperlipidemia-arbitrated mitochondrial oxidative insult is key reason for cardiac dysfunction cardiomyopathy. Sinapic acid (SA) a hydroxycinnamic (a polyphenolic acid) present in multiple plants possesses several pharmacological activities. In this study, we examined the cardio protective effects of SA on streptozotocin (STZ)-induced insults. STZ both induced diabetes normal control rats were administered with 20 40 mg/kg 12 weeks. demonstrated hyperglycemia...
The receptor-binding domain (RBD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mediates the viral–host interaction and is a target for most neutralizing antibodies. Nevertheless, SARS-CoV-2 RBD mutations pose threat due to their role in host cell entry via human angiotensin-converting enzyme receptor that might strengthen infectivity, viral load, or resistance against To understand molecular structural link between top five mutant RBDs (i.e., N501Y, E484K L452R, S477N,...
Abstract In this research, we produced copper oxide nanoparticles (CuO NPs) using extracts from the entire above-ground portion of plants genus Inula ( graveolens ). The synthesis CuO NPs was verified through various physicochemical analytical methods, including UV–visible, Fourier transform infrared, and transmission electron microscopy. were found to be around 20 nm in size spherical shape. Subsequently, synthesized compounds evaluated for their anticancer properties. After treating A549...
Fluoropyrimidine 5-fluorouracil (5-FU) is a DNA analogue broadly used in chemotherapy, though treatment-associated nephrotoxicity limits its widespread clinical use. Sinapic acid (SA) has potent antioxidant, anti-inflammatory, and anti-apoptotic effects, we investigated protective effects against 5-FU-induced rat model. We designated four treatment groups each Group I (control) received five intraperitoneal saline injections (once daily) from days 17 to 21; II of 5-FU (50 mg/kg/day) III an...
This study aimed to deliver a cationic nanoemulsion carrying miconazole nitrate (MCN) control fungal infections using excipients for synergism. Peceol (oil) and labrasol (surfactant) were selected based on maximum solubility zone of inhibition values against Candida albicans Aspergillus niger. Optimized MCNE11 was evaluated [size, zeta potential, % entrapment efficiency (%EE), transmittance, viscosity, refractive index, extrudability, polydispersity (PDI), morphology, pH]. An in vitro drug...
ABSTRACT This study investigates the metabolic disruptions caused by nicotine (NIC) exposure, with a particular focus on amino acid and lipid metabolism, evaluates resveratrol (RSV) as potential protective agent. Mice were divided into four groups: control (CON), NIC‐exposed, NIC + RSV‐treated, RSV‐only. exposure resulted in significant weight loss, elevated glucose levels, altered profiles, organ damage, particularly liver kidneys. Increased inflammation was evidenced levels of IL‐6 CRP. In...
SPINAccepted Papers No AccessExploring Multiple Magnetization Plateaus in Graphdiyne-like Nanolattice Using Monte Carlo SimulationsHussein Sabbah, R. El Fdil, Z. Fadil, Mudassar Shahid, Seong Cheol Kim, Chaitany Jayprakash Raorane, and Mohhammad RamzanHussein Fdil Search for more papers by this author , Fadilhttps://orcid.org/0000-0001-8855-1074 Shahid Kim Raorane Ramzan https://doi.org/10.1142/S2010324725500018Cited by:0 (Source: Crossref) PreviousNext...
DL-2-aminobutyric acid (α-aminobutyric acid), an alpha amino acid, has been extensively investigated through experimental and theoretical methods. Theoretical analyses have carried out using density functional theory. Spectroscopic techniques such as Fourier transform infrared UV spectroscopy employed, with spectra aligning closely predictions. Studies of electronic transitions between unoccupied occupied states performed in solvents like dimethyl sulfoxide (DMSO) Methanol (MeOH). The Time...
The current investigation focuses on synthesizing Ag-Fe bimetallic nanoparticles (AgFe-BMNPs) using cell-free filtrates of the Gymnascella dankaliensis as a novel fungal reducing agent. optical, morphological, and surface properties these fungus-fabricated AgFe-BMNPs their monometallic counterparts (AgNPs FeNPs) were analyzed sophisticated nanotechnology instruments. UV-visible spectrum showed peaks at 231 nm 415 for BMNPs 450 386 AgNPs FeNPs, respectively. XRD diffractograms revealed...
Cigarette smoking is a leading cause of preventable mortality, largely due to the absence effective, non-invasive biomarkers for early disease detection. Profiling serum metabolomics identify metabolic changes holds potential accelerate detection process and individuals at risk developing smoking-related diseases. This study investigated biochemical metabolomic induced by nicotine exposure, with focus on disruptions in amino acid, lipid, carbohydrate metabolism. Liquid chromatography-tandem...