A5015664157- Dental Implant Techniques and Outcomes
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Bone Tissue Engineering Materials
- Dental materials and restorations
- Pharmacogenetics and Drug Metabolism
- Oral microbiology and periodontitis research
- Periodontal Regeneration and Treatments
- Dental Radiography and Imaging
- Vascular Malformations Diagnosis and Treatment
- Salivary Gland Disorders and Functions
- Intracerebral and Subarachnoid Hemorrhage Research
- Orthodontics and Dentofacial Orthopedics
- Intracranial Aneurysms: Treatment and Complications
- Oral Health Pathology and Treatment
- Temporomandibular Joint Disorders
- Electrospun Nanofibers in Biomedical Applications
- Mesenchymal stem cell research
- Dental Research and COVID-19
- Neonatal Respiratory Health Research
- Cystic Fibrosis Research Advances
- Ion Transport and Channel Regulation
- Cell Adhesion Molecules Research
- Orthopaedic implants and arthroplasty
- Bone and Dental Protein Studies
High Point University
2025
Medical University of South Carolina
2023-2024
Virginia Commonwealth University
2017-2023
American College
2021
John Wiley & Sons (United States)
2021
Engineering Associates (United States)
2021
Nova Southeastern University
2021
Anatolia College
2021
Faculty of 1000 (United States)
2017-2018
University of North Carolina at Chapel Hill
2006-2016
Significance Cystic fibrosis (CF) is caused by mutations in the cystic transmembrane conductance regulator ( CFTR ) gene, which codes for a chloride/bicarbonate channel whose absence leads to dehydration and acidification of CF airways. A contributing factor lung disease dysregulation epithelial Na + (ENaC), exacerbates mucus dehydration. Here, we show that ENaC hyperactivity airways direct consequence acidic airway surface liquid (ASL) ASL hydration restored raising pH. Additionally, short...
Cerebral cavernous malformations (CCM) are sporadic or inherited vascular lesions of the central nervous system characterized by dilated, thin-walled, leaky vessels. Linkage studies have mapped autosomal dominant mutations to three loci: ccm1 (KRIT1), ccm2 (OSM), and ccm3 (PDCD10). All proteins appear be scaffolds adaptor proteins, as no enzymatic function can attributed them. Our previous results demonstrated that OSM is a scaffold for assembly GTPase Rac MAPK kinase MEKK3, hyperosmotic...
The epithelial sodium channel (ENaC) is responsible for Na + and fluid absorption across colon, kidney, airway epithelia. Short palate lung nasal clone 1 (SPLUNC1) a secreted, innate defense protein an autocrine inhibitor of ENaC that highly expressed in While SPLUNC1 has bactericidal permeability-increasing (BPI)-type structure, its NH 2 -terminal region lacks structure. Here we found 18 amino acid peptide, S18, which corresponded to residues G22-A39 the terminus inhibited activity similar...
Human carboxylesterase 1 (hCE1) is a serine esterase involved in both drug metabolism and activation, as well other biological processes. hCE1 catalyses the hydrolysis of heroin cocaine, transesterification cocaine presence ethanol to toxic metabolite cocaethylene. We have determined crystal structures complex with either analogue homatropine or naloxone. These are first human carboxylesterase, they provide details about narcotic humans. hCE1's active site contains rigid flexible pockets,...
The human nuclear pregnane X receptor (PXR) responds to a wide variety of xenobiotic and endobiotic compounds, including pregnanes, progesterones, corticosterones, lithocholic acids, 17beta-estradiol. In response these ligands, the controls expression genes central metabolism excretion potentially harmful chemicals from both exogenous endogenous sources. Although structural basis PXR's interaction with small large xenobiotics has been examined, detailed nature its binding endobiotics,...
Effective monitoring of glucose levels is necessary for patients to achieve greater control over their diabetes. However, only about a quarter subjects with diabetes who requires close serum monitoring, regularly check daily. One the potential barriers patient compliance blood sampling requirement. Saliva and its protein contents can be altered in diabetes, possibly due changes glycemic control. We propose here that salivary proteomes may different based on as reflected A1C levels. A total...
Abstract Purpose Removal of cement‐retained implant crowns can be difficult and often requires sectioning the prosthesis by rotary instruments. This study aimed to measure how much time is required in crown removal temperature changes when erbium‐doped yttrium aluminum garnet (Er:YAG) laser was used retrieve lithium disilicate from titanium abutments luted with composite resin (CR) cement resin‐modified glass ionomer (RMGI). Materials Methods Forty identical were fabricated for prefabricated...