A5064099926- Respiratory viral infections research
- Insect-Plant Interactions and Control
- HIV/AIDS drug development and treatment
- Antifungal resistance and susceptibility
- HIV Research and Treatment
- Biochemical and Molecular Research
- Insect Pheromone Research and Control
- Insect Pest Control Strategies
- Asthma and respiratory diseases
- Forest Insect Ecology and Management
- Neonatal Respiratory Health Research
- Pneumonia and Respiratory Infections
- Tracheal and airway disorders
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Influenza Virus Research Studies
- Retinoids in leukemia and cellular processes
- Viral gastroenteritis research and epidemiology
- Insect Resistance and Genetics
- Legionella and Acanthamoeba research
- Immune Cell Function and Interaction
- Animal Virus Infections Studies
- Hemiptera Insect Studies
- Immunodeficiency and Autoimmune Disorders
- Biological Control of Invasive Species
Agriculture and Agri-Food Canada
1953-2014
GlaxoSmithKline (United Kingdom)
2001-2007
Wellcome Library
1999-2001
Research Triangle Park Foundation
1999
The local immune response to influenza virus infection was characterized by determining cytokine and chemokine levels in serial nasal lavage fluid samples from 15 volunteers experimentally infected with A/Texas/36/91 (H1N1). study part of a randomized double-blind placebo-controlled trial determine the prophylactic effect intravenous zanamivir (600 mg 2×/day for 5 days), highly selective inhibitor A B neuraminidases, on clinical symptoms infection. Nasal interleukin (IL)-6, tumor necrosis...
Respiratory syncytial virus (RSV) bronchiolitis is a major cause of morbidity and mortality in infancy. Severe disease believed to result from uncontrolled viral replication, an excessive immune response, or both.To determine RSV load mediator levels nasal mucosal lining fluid by serial sampling fluids cases moderate severe over the course infection.Infants with necessitating admission (n = 55) were recruited pediatric center during 2016 2017. Of these, 30 infected (18 "moderate" 12...
ABSTRACT Zanamivir is a potent inhibitor of influenza A and B virus neuraminidases active topically in experimental natural human influenza. We conducted this double-blinded, placebo-controlled study to evaluate the safety efficacy intravenously administered zanamivir. Susceptible volunteers were randomized receive either saline or zanamivir (600 mg) twice daily for 5 days beginning 4 h prior intranasal inoculation with ∼10 50% tissue culture infectious doses (TCID 50 ) A/Texas/36/91 (H1N1)...
Abstract PC945 is a novel antifungal triazole formulated for nebulized delivery to treat lung Aspergillus infections. Pharmacokinetic and safety profiles from nonclinical studies clinical trials in healthy subjects, subjects with mild asthma were characterized. Toxicokinetics assessed following daily 2‐hour inhalation 14 days. Potential drug‐drug interactions was evaluated using pooled human liver microsomes. Clinical pharmacokinetics (a) single inhaled doses (0.5‐10 mg), (b) 7‐day repeat (5...
ABSTRACT Although respiratory syncytial virus (RSV) is the most common cause of lower tract infection in infants and young children, attempts to develop an effective therapy have so far proved unsuccessful. Here we report preclinical profiles PC786, a potent nonnucleoside RSV L protein polymerase inhibitor, designed for inhalation treatment infection. PC786 demonstrated selective antiviral activity against laboratory-adapted or clinical isolates RSV-A (50% inhibitory concentration [IC 50 ],...
Abstract Background PC786 is a nebulized nonnucleoside respiratory syncytial virus (RSV) polymerase inhibitor designed to treat RSV, which replicates in the superficial layer of epithelial cells lining airways. Methods Fifty-six healthy volunteers inoculated with RSV-A (Memphis 37b) were randomly dosed either (5 mg) or placebo, twice daily for 5 days, from 12 hours after confirmation RSV infection 6 days inoculation. Viral load (VL), disease severity, pharmacokinetics, and safety assessed...
Existing respiratory mucosal sampling methods are flawed, particularly in a pediatric bronchiolitis setting. Twenty-four infants with were recruited: 12 syncytial virus (RSV)–positive, RSV-negative. Infants sampled by nasosorption and nasopharyngeal aspiration (NPA). Nasosorption was well tolerated identified all RSV+ samples. RSV load measured (but not NPA) correlated length of hospital stay (P = .04) requirement for mechanical ventilation .03). levels interferon γ, interleukin 1β,...
Background: Adenosine receptor activation is suggested to play a role in asthmatic airway inflammation. Inhibition of adenosine receptors may have an effect on the late response (LAR) after allergen inhalation and this mechanism could offer potential new treatment asthma. Methods: We evaluated inhaled adenosine‐ 2A (A )‐receptor agonist (GW328267X), 25 μg, 15 nonsmoking atopic asthmatics who underwent challenge following twice daily for 1 week double‐blind, placebo‐ fluticasone propionate...
Background and Purpose Effective anti‐respiratory syncytial virus (RSV) agents are still not available for clinical use. Current major targets surface proteins, such as a fusion protein involved in viral entry, but effective after RSV infection is established required. Here we have investigated the effects of late therapeutic intervention with novel inhaled polymerase inhibitor, PC786, on human airway epithelium. Experimental Approach Air liquid interface‐cultured bronchial or small...
Cabbage and related crops are attacked every year throughout Ontario by caterpillars of three species, namely, the imported cabbageworm, Pieris rapae (L.), diamondback moth, Plutella maculipennis (Curt.), cabbage looper, Trichoplusia ni (Hbn.). The cabbageworm is generally regarded as most abundant species reported doing damage considerable economic importance each year. looper does not occur in large numbers until late season, but years it believed to be second only cabbageworm. moth...
Abstract Adverse effects can compromise oral voriconazole treatment of pulmonary aspergillosis. Inhaled low‐dose may be an alternative treatment. In this study, six patients inhaled 40 mg b.i.d. for 2 days, and ingested 400 200 orally on day one two, respectively. Blood samples were collected after the first inhalation, bronchial alveolar lavage fluids blood measurements 12 hr last administration. The concentration in epithelial lining fluid ( ELF ) was calculated by urea dilution method....
The effect of food on the bioavailability GW420867X, a novel nonnucleoside reverse transcriptase inhibitor, was investigated in 15 young, healthy, male volunteers. A single oral dose GW420867×100 mg administered fasted state, after high‐fat meal, and meal normal fat composition. Tolerability pharmacokinetic sampling were assessed at baseline up to 600 hours. median concentration‐time plots for each treatment group essentially superimposable. Neither rate nor extent absorption GW420867X...
Although many traps have been designed to study the responses of Lepidoptera light sources various intensities and qualities (Gui et al. , 1942; Taylor Deay, 1950; Glick Hollingsworth, 1954; Merkl Pfrimmer, 1955; Frost, 1957), few for studies flight periodicity. The first one latter purpose was described by Seamans Gray (1934). It consisted seven individual collecting units built into structure, each unit being operated hour night. Interval subsequently Hutchins (1940), Nagel Granovsky...
Purpose: GW420867X is a nonnucleoside inhibitor of HIV-1 reverse transcriptase. The primary objective was to assess the safety in HIV-1-infected patients. secondary objectives were effect on plasma RNA and viral genotype phenotype examine pharmacokinetics Method: patients randomized 50 mg/day, 100 or 200 mg/day from days 1-28 (n = 15 per group). Lamivudine (3TC) plus zidovudine (ZDV) added 8-28. A control group 15) received GW420867X, 3TC, ZDV placebos. Results: Plasma CD4+ counts improved...
Abstract Background RSV is the most common cause of bronchiolitis in infants and responsible for severe respiratory infections elderly immunocompromised populations. replicates columnar epithelial cells proximal distal airways which are accessible to inhaled therapies. PC786 a potent non-nucleoside L-protein polymerase inhibitor designed delivery. In preclinical studies, exhibits prolonged lung tissue residence with minimal systemic exposure, thus limiting potential adverse effects. Methods...