A5002750710- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Historical Philosophy and Science
- Medieval and Classical Philosophy
- Nursing education and management
- Reflective Practices in Education
- Atomic and Subatomic Physics Research
- Classical Philosophy and Thought
- Interprofessional Education and Collaboration
- Theology and Philosophy of Evil
- MicroRNA in disease regulation
- Cardiac Imaging and Diagnostics
- Circular RNAs in diseases
- Palliative Care and End-of-Life Issues
- Family and Patient Care in Intensive Care Units
- Counseling, Therapy, and Family Dynamics
- Ethics in medical practice
- Nursing Education, Practice, and Leadership
- Adult and Continuing Education Topics
- Radiomics and Machine Learning in Medical Imaging
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Congenital Heart Disease Studies
- Angiogenesis and VEGF in Cancer
- Seventeenth-Century Political and Philosophical Thought
- Medieval Philosophy and Theology
University of Sheffield
2016-2025
Denver Health Medical Center
2025
University of Colorado Denver
2025
University of California, San Francisco
2025
Chesterfield Royal Hospital NHS Foundation Trust
2024
Sheffield Teaching Hospitals NHS Foundation Trust
2014-2024
Royal Hallamshire Hospital
2017-2024
Northern General Hospital
2024
Pulmonary Vascular Research Institute
2024
Digital Health Cooperative Research Centre
2022
Carper's fundamental ways of knowing have been utilized as a framework for the practitioner to consider what he or she has learnt through reflection on experience. The purpose this paper is consider, an interpretation writings and analysing one practitioner's experience shared in supervision milieu, whether use work can be reasonably justified theoretical practical level
This paper notes the dawning of reflective practice on horizon nursing and sets out to explore its value for nursing. Central this is potential enable practitioners develop clinical expertise towards achieving desirable effective and, through collaborative research, development a valid disciplinary knowledge grounded in practitioners' personal knowledge.
Rationale: Prognostication is important when counseling patients and defining treatment strategies in pulmonary arterial hypertension (PAH).Objectives: To determine the value of magnetic resonance imaging (MRI) metrics for prediction mortality PAH.Methods: Consecutive with PAH undergoing MRI were identified from ASPIRE (Assessing Spectrum Pulmonary Hypertension Identified at a Referral Centre) registry.Measurements Main Results: During follow-up period 42 (range, 17–142) months 576 studied...
Abstract Bone marrow–derived endothelial progenitor cells (EPC) contribute to the angiogenesis-dependent growth of tumors in mice and humans. EPCs regulate angiogenic switch via paracrine secretion proangiogenic factors by direct luminal incorporation into sprouting nascent vessels. miRNAs have emerged as key regulators several cellular processes including angiogenesis; however, whether bone marrow–mediated angiogenesis has remained unknown. Here, we show that genetic ablation...
Rationale: Pulmonary arterial hypertension (PAH) is a life-shortening condition. The European Society of Cardiology and Respiratory the REVEAL (North American Registry to Evaluate Early Long-Term PAH Disease Management) risk score calculator (REVEAL 2.0) identify thresholds predict 1-year mortality.Objectives: This study evaluates whether cardiac magnetic resonance imaging (MRI) can be identified used aid stratification facilitate decision-making.Methods: Consecutive patients with (n = 438)...
We evaluated the prevalence and prognostic value of CT-pulmonary angiographic (CTPA) measures in 292 treatment naive patients with pulmonary arterial hypertension (PAH). Pulmonary artery calcification (13%) thrombus (10%) were exclusively seen PAH-congenital heart disease. Oesophageal dilation (46%) was most frequent PAH-systemic sclerosis. Ground glass opacification (GGO) (41%), pericardial effusion (38%), lymphadenopathy (19%) pleural (11%) common. On multivariate analysis, inferior vena...
Pulmonary endarterectomy (PEA) is the gold standard treatment for operable chronic thromboembolic pulmonary hypertension (CTEPH). However, a proportion of patients with disease decline surgery. There are currently no published data on this patient group. The aim study was to identify outcomes and prognostic factors in large cohort consecutive CTEPH.Data were collected consecutive, treatment-naive CTEPH at Vascular Disease Unit Royal Hallamshire Hospital (Sheffield, UK) between 2001 2014.Of...
Purpose To assess the diagnostic accuracy of magnetic resonance imaging (MRI) perfusion against single photon emission tomography (SPECT) screening for chronic thromboembolic pulmonary hypertension (CTEPH). Ventilation/perfusion (V/Q) scintigraphy is recommended to screen suspected CTEPH. It has previously been shown that 3D dynamic contrast‐enhanced (DCE) lung MRI a similar sensitivity diagnosing CTEPH in comparison planar scintigraphy; however, now largely replaced by SPECT, due higher...
Pulmonary arterial hypertension (PAH) is a progressive condition with high mortality. Quantitative cardiovascular magnetic resonance (CMR) imaging metrics in PAH target individual cardiac structures and have diagnostic prognostic utility but are challenging to acquire. The primary aim of this study was develop test tensor-based machine learning approach holistically identify features using CMR, secondarily, visualize interpret key discriminative associated PAH.Consecutive treatment naive...
Computed tomography (CT) pulmonary angiography is widely used in patients with suspected hypertension (PH). However, the diagnostic and prognostic significance remains unclear. The aim of this study was to (a) build a CT model (b) test its significance.Consecutive PH undergoing routine right heart catheterisation (RHC) were identified. Axial reconstructed images derive metrics. Multivariate regression analysis performed derivation cohort identify predict mPAP ≥ 25 mmHg (the existing ESC...
Background There is clinical need to better quantify lung disease severity in pulmonary hypertension (PH), particularly idiopathic arterial (IPAH) and PH associated with (PH-LD). Purpose To fibrosis on CT angiograms using an artificial intelligence (AI) model assess whether this approach can be used combination radiologic scoring predict survival. Materials Methods This retrospective multicenter study included adult patients IPAH or PH-LD who underwent incidental imaging between February...
Purpose To derive and test multiparametric cardiac MRI models for the diagnosis of pulmonary hypertension (PH). Materials Methods Images patient data from consecutive patients suspected having PH who underwent right-sided heart catheterization (RHC) between 2012 2016 were retrospectively reviewed. Of 2437 MR images identified, 603 fit inclusion criteria. The mean age was 61 years (range, 18–88 years; women, 60 [range, 18–84 years]; men, 62 22–88 years]). In first 300 (derivation cohort),...
Background Cardiac MRI measurements have diagnostic and prognostic value in the evaluation of cardiopulmonary disease. Artificial intelligence approaches to automate cardiac segmentation are emerging but require clinical testing. Purpose To develop evaluate a deep learning tool for quantitative functional studies assess its use prognosis patients suspected having pulmonary hypertension. Materials Methods A retrospective multicenter multivendor data set was used learning–based contouring...
Abstract Aims Pulmonary arterial hypertension (PAH) is a rare but serious disease associated with high mortality if left untreated. This study aims to assess the prognostic cardiac magnetic resonance (CMR) features in PAH using machine learning. Methods and results Seven hundred twenty-three consecutive treatment-naive patients were identified from ASPIRE registry; 516 included training, 207 validation cohort. A multilinear principal component analysis (MPCA)-based learning approach was used...
The Ability of Helical CT to Preoperatively Stage Endometrial CarcinomaLara A. Hardesty1, Jules H. Sumkin1, Christiane Hakim1, Christopher Johns1 and Manju Nath2Audio Available | Share
Guided reflection provides a challenging and supportive milieu for practitioners to learn through towards achieving desirable work. This work inevitably demands confrontation with self the conditions of practice that limit achievement It also an understanding what is nursing. From ideological position, generally defined in terms humanistic caring. The paper discusses how caring can be visualized realized experiences reflect on share within guided reflection. illustrated using dialogue.