A5063409018- Lymphatic System and Diseases
- Hippo pathway signaling and YAP/TAZ
- Developmental Biology and Gene Regulation
- Single-cell and spatial transcriptomics
- Planarian Biology and Electrostimulation
Peter MacCallum Cancer Centre
2023-2024
The University of Melbourne
2023-2024
During development, the lymphatic vasculature forms as a second network derived chiefly from blood vessels. The transdifferentiation of embryonic venous endothelial cells (VECs) into (LECs) is key step in this process. Specification, differentiation and maintenance LEC fate are all driven by transcription factor Prox1, yet downstream mechanisms remain to be elucidated. We here present single-cell transcriptomic atlas lymphangiogenesis zebrafish, revealing new markers hallmarks over four...
ABSTRACT During embryonic development, lymphatic endothelial cell (LEC) precursors are distinguished from blood cells by the expression of Prospero-related homeobox 1 (Prox1), which is essential for vasculature formation in mouse and zebrafish. Prox1 initiation precedes LEC sprouting migration, serving as marker specified LECs. Despite its crucial role upstream regulation LECs remains to be uncovered. SOX18 COUP-TFII thought regulate mice binding promoter region. However, specific studied...
Abstract Lymphatic vessels play a role in several physiological and pathological processes including tissue fluid homeostasis, dietary fat absorption, immunosurveillance, immunomodulation. During embryonic development, lymphatic endothelial cell (LEC) precursors are distinguished from blood cells by the expression of transcription factor Prospero-related homeobox 1 ( PROX1). PROX1 is essential for vascular network formation mouse zebrafish. The initiation precedes LEC sprouting migration,...