A5082779313- Telomeres, Telomerase, and Senescence
- MicroRNA in disease regulation
- Circular RNAs in diseases
- DNA Repair Mechanisms
- Forensic and Genetic Research
- Nutrition, Genetics, and Disease
- Genetics and Neurodevelopmental Disorders
- Neurogenesis and neuroplasticity mechanisms
- Effects of Radiation Exposure
- Genetics, Aging, and Longevity in Model Organisms
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- RNA regulation and disease
- Extracellular vesicles in disease
- Skin Protection and Aging
- Genetic and rare skin diseases.
Shiga University of Medical Science
2018-2025
Keio University Hospital
2014
RIKEN Center for Integrative Medical Sciences
2014
Significance Neural stem/progenitor cells (NSPCs) restrict their differentiation potential by developmental stage-dependent temporal specification. Thereby, specific and efficient induction of homogeneous target cell populations remains a challenge in stem biology. Here, we provided solution identifying the molecular machinery responsible for neurogenic-to-gliogenic transition NSPCs, process termed “competence change.” We identified microRNA-17/106–p38 axis as critical regulator competence...
Senescence increases the risks of inflammatory bowel diseases and colon cancer. Intestinal stem cells (ISCs) in crypts differentiate into epithelial thereby maintain intestinal homeostasis. However, influence aging on functions ISCs is largely unknown. The mutation rate highest small large intestines. Numerous types naturally occurring DNA damage are removed by response (DDR). This induces repair apoptosis; therefore, its dysregulation leads to accumulation damaged consequently cellular...
When the regulation of axonal and dendritic growth is altered, neuronal network becomes disordered, which may contribute to development psychiatric disorders. Some genome analyses have suggested relationships between mutations in strawberry notch homologue 1 (SBNO1) neurodevelopmental However, function SBNO1 has not yet been reported. Here, expression pattern during cerebral cortex mice was examined. strongly expressed cortical plate its maintained at a low level postnatal stage....
Abstract Molecular mechanisms of aging specific to each stem cell (SC) are being elucidated. However, the common molecular basis for senescence in various SCs remains largely unexplored. Here, we have shown that dysregulation DNA damage response (DDR) modulated by lymphoid enhancer-binding factor 1 ( Lef1 ) and DDR-microRNAs (DDR-miRs) is SCs. We identified as most repressed transcription with between mesenchymal stem/stromal cells (MSCs) hematopoietic stem/progenitor cells. Like expression...
Abstract Molecular mechanisms of aging specific to each stem cell (SC) are being elucidated. However, the common molecular basis for senescence in various SCs remains largely unexplored. Here, we have shown that dysregulation DNA damage response (DDR) modulated by lymphoid enhancer-binding factor 1 ( Lef1 ) and DDR-microRNAs (DDR-miRs) is SCs. We identified as most repressed transcription with between mesenchymal stem/stromal cells (MSCs) hematopoietic stem/progenitor cells. Like expression...
Abstract Molecular mechanisms of aging specific to each stem cell (SC) are being elucidated. However, the common molecular basis for senescence in various SCs remains largely unexplored. Here, we have shown that dysregulation DNA damage response (DDR) modulated by lymphoid enhancer-binding factor 1 ( Lef1 ) and DDR-microRNAs (DDR-miRs) is SCs. We identified as most repressed transcription with between mesenchymal stem/stromal cells (MSCs) hematopoietic stem/progenitor cells. Like expression...