A5021743127- Catalytic C–H Functionalization Methods
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic Cross-Coupling Reactions
- Synthesis and Catalytic Reactions
- Fluorine in Organic Chemistry
- Catalytic Alkyne Reactions
- Asymmetric Hydrogenation and Catalysis
- Chemical Synthesis and Analysis
- Organoboron and organosilicon chemistry
- Inorganic Fluorides and Related Compounds
- Oxidative Organic Chemistry Reactions
- Crystallography and molecular interactions
- Synthetic Organic Chemistry Methods
- Alkaloids: synthesis and pharmacology
- Bioactive Compounds and Antitumor Agents
- Axial and Atropisomeric Chirality Synthesis
- Traditional and Medicinal Uses of Annonaceae
- Cyclopropane Reaction Mechanisms
Université Côte d'Azur
2023-2025
Institut de Chimie de Nice
2023-2025
Observatoire de la Côte d’Azur
2025
Max-Planck-Institut für Kohlenforschung
2021
University of Basel
2016-2020
École d'Ingénieurs en Chimie et Sciences du Numérique
2015-2016
Université Claude Bernard Lyon 1
2015-2016
Centre National de la Recherche Scientifique
2015-2016
Institut de Chimie et Biochimie Moléculaires et Supramoléculaires
2015-2016
High enantioselectivities can be achieved using an appropriate chiral base/achiral ligand combination in Pd<sup>0</sup>-catalyzed C(sp<sup>3</sup>)–H activation.
The Cu-catalyzed direct difluoroalkylation of aldehyde hydrazones with functionalized difluoromethyl bromides is described. reaction yields stereodefined α,α–difluoro-β-keto under mild conditions and can be carried out at a scale that opens up the possibility practical applications.
Abstract A palladium‐catalyzed C(sp 2 )−H difluoromethylation of aldehyde‐derived hydrazones using bromodifluoromethylated compounds to afford the corresponding functionalized difluoromethylketone has been established. It is proposed that a radical/SET mechanism proceeding via difluoroalkyl radical may be involved in catalytic cycle. Applications methodology synthesis α,α‐difluoro‐β‐ketoesters and α,α‐difluoroketones (RCOCF H) have illustrated.
A divergent enantioselective synthesis of (nor)illudalane sesquiterpenes was designed by using a Pd0-catalyzed asymmetric C(sp3)–H arylation as key step to control the isolated, highly symmetric quaternary stereocenter target molecules. matched combination chiral substrate and catalyst proved optimal reach good levels stereoselectivity. This approach enabled three (nor)illudalanes, including (S)-deliquinone (S)-russujaponol F, which are synthesized for first time in enantioenriched form.
An unprecedented and green synthetic route for the preparation of functionalized polycyclic azaborine skeletons via a ruthenium-mediated ring-closing enyne metathesis transformation alkynyl B-anthranilamide (aam) is reported. A variety B(aam)-bridge derivatives were engaged with Grubbs-II catalyst, affording corresponding exo-cyclic compounds (28 novel derivatives). The methodology was efficiently optimized in dimethyl carbonate as solvent provided direct access to boronated scaffolds...
Abstract The enantioselective functionalization of nonactivated enantiotopic secondary C−H bonds is one the greatest challenges in transition‐metal‐catalyzed activation proceeding by an inner‐sphere mechanism. Such reactions have remained elusive within realm Pd 0 catalysis. Reported here unique reactivity profile IBiox ligand family ‐catalyzed intramolecular arylation such bonds. Chiral C 2 ‐symmetric ligands led to high enantioselectivities for a broad range valuable indane products...
Abstract A synthetic route for the preparation of alkynylated saturated N‐heterocycles via a sequential combination Shono oxidation and gold(I)‐catalyzed alkynylation reaction has been developed. The electrochemical allowed an efficient access to variety N , O ‐acetals direct C−H bond functionalization cyclic amines. conditions were amenable with functionalized pyrrolidine, tetrahydroisoquinoline pyrrolidine‐cyclopropyl fused bicyclic skeletons. gold‐catalyzed process introduction aryl...
Three (nor)illudalane sesquiterpenes were synthesized from a common intermediate in racemic and enantioenriched forms using Pd0-catalyzed C(sp3)–H arylation as key step. The configuration of the isolated, highly symmetric quaternary stereocenter target molecules was controlled through matched combination chiral substrate catalyst. Moreover, recently developed Ir-catalyzed C–H borylation/Cu-catalyzed methylation method employed to install methyl group on benzene ring. This strategy allowed...
Abstract Alkynyl‐B(aam) (aam=anthranilamidato) derivatives are readily available bench‐stable compounds that undergo remarkably selective reactions with Bu 3 SnH in the presence of [Cp*RuCl] 4 as catalyst. The addition follows a stereochemically unorthodox trans ‐selective course; terms regioselectivity, Sn‐ unit is delivered high fidelity to C‐atom triple bond adjacent boracyclic head group (“ alpha,trans ‐addition”). This outcome deemed reflect hydrogen bonding interaction between protic...
Abstract The enantioselective functionalization of nonactivated enantiotopic secondary C−H bonds is one the greatest challenges in transition‐metal‐catalyzed activation proceeding by an inner‐sphere mechanism. Such reactions have remained elusive within realm Pd 0 catalysis. Reported here unique reactivity profile IBiox ligand family ‐catalyzed intramolecular arylation such bonds. Chiral C 2 ‐symmetric ligands led to high enantioselectivities for a broad range valuable indane products...
Abstract The Pd‐catalyzed difluoromethylation of aldehyde‐derived hydrazones using bromodifluoromethylated compounds affords functionalized difluoromethylketone hydrazones.