A5044773744- Olfactory and Sensory Function Studies
- Head and Neck Surgical Oncology
- Sinusitis and nasal conditions
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Obstructive Sleep Apnea Research
- Tracheal and airway disorders
- Advanced Chemical Sensor Technologies
- Biochemical Analysis and Sensing Techniques
- Nasal Surgery and Airway Studies
- Neuroscience of respiration and sleep
- Microbial Metabolic Engineering and Bioproduction
- Enzyme Catalysis and Immobilization
- Pituitary Gland Disorders and Treatments
- Cleft Lip and Palate Research
- IgG4-Related and Inflammatory Diseases
- Biofuel production and bioconversion
- Neurobiology and Insect Physiology Research
- Ear and Head Tumors
- Food Security and Health in Diverse Populations
- Airway Management and Intubation Techniques
- Ear Surgery and Otitis Media
- Pediatric health and respiratory diseases
- Craniofacial Disorders and Treatments
- Marine and Coastal Research
Ewha Womans University
2020-2024
Uijeongbu St. Mary's Hospital
2017-2020
Catholic University of Korea
2008-2020
Ewha Womans University Medical Center
2020
Sookmyung Women's University
2016-2020
Fundación Juan March
2020
Seoul Medical Center
2018
Seoul St. Mary's Hospital
2017
National Research Foundation of Korea
2016
Ministry of Health and Welfare
2016
The increased number of endoscopic endonasal transsphenoidal approaches (EETSA) has been associated with sinonasal complications such as olfactory dysfunction. Current studies have compared preoperative and postoperative function according to surgical type age.Retrospective review medical records at a tertiary referral center.Patients were divided into two groups four age. defined based on the bilateral nasoseptal flap technique (group A: right conventional left modified rescure flap; group...
A novel microbial esterase, EaEST, from a psychrophilic bacterium Exiguobacterium antarcticum B7, was identified and characterized. To our knowledge, this is the first report describing structural analysis biochemical characterization of an esterase isolated genus Exiguobacterium. Crystal structure determined at resolution 1.9 Å, showed that enzyme has canonical α/β hydrolase fold with α-helical cap domain catalytic triad consisting Ser96, Asp220, His248. Interestingly, active site EaEST...
Allergic rhinitis (AR) and rhinosinusitis (RS) negatively impact psychological well-being health-related quality of life (HRQoL). However, few population-based studies have investigated the effects these conditions on mental health HRQoL.To explore independent associations AR and/or RS with HRQoL using data from 2013-2015 Korea National Health Nutrition Examination Survey (KNHANES).The KNHANES is a nationwide cross-sectional survey non-institutionalized population Korea. A total 15,441...
Several studies have reported the benefits of olfactory training (OT) in nervous system mouse models. Therefore, this study we performed next-generation sequencing to evaluate effects OT on mRNA area.Mice each group were administered 300 mg 3-methylindole per kilogram weight. The function was evaluated by a food-finding test once week. neuroepithelium harvested for histologic examination and protein analysis. Subsequently, data analysis, gene ontology pathway quantitative real-time...
Background Several studies have reported beneficial effects of olfactory training (OT) on the nervous system. However, mechanisms underlying regeneration system induced by OT are still under investigation. Objectives To determine key involved in recovery and to assess neuroplastic OT. Methods Thirty healthy female C57BL/6 mice were randomly allocated 4 groups: control, n = 6; anosmia (no treatment), 8; OT, steroid treatment; 8. Except for control group, administered 3-methylindole. Anosmia...
Fat-graft myringoplasty (FGM) has a reliable tympanic closure rate for small to large perforations, but yields poor hearing improvement in the latter case. A topographic evaluation of FGM showed that procedure resulted perforation and audiologic outcome, regardless location.This study assessed utility treating perforations different sizes locations.This retrospective involved 45 patients (46 ears) who underwent at St Mary's Hospital (Seoul, Korea) between August 2007 February 2010.The total...
A male Mongolian child with a complete congenital absence of both nose and nasal passage had poor survival prognosis due to respiratory distress. To enable his survival, new capable conferring function was constructed. Following reconstructive surgery, an mucoepithelium in the can lead rhinostenosis. avoid this complication, custom‐made silicone stent created using three‐dimensional (3D) printing technology conjunction patient's computed tomography data. The implanted for 2 months maintain...
Abstract Considering that the prevalence of antibiotic-resistant pathogenic bacteria is largely increasing, a thorough understanding penicillin-binding proteins (PBPs) great importance and crucial significance because this enzyme family main target β-lactam-based antibiotics. In work, combining biochemical structural analysis, we present new findings provide novel insights into PBPs. Here, PBP homologue (CcEstA) from Caulobacter crescentus CB15 was characterized using native-PAGE, mass...
In this study, we addressed the immunotherapeutic potential of human placental extract (HPE) in a murine allergic rhinitis (AR) model and explored its immunological mechanisms.In vivo study using an animal model.HPE was administered to BALB/c mice before sensitization with allergen (Dermatophagoides farinae [Derf]) (pre-S group) or after challenge (post-C group). The groups were compared Derf-treated that received no HPE (Derf phosphate buffered saline (PBS)-treated (control). Allergic...
motrypsin, plasmin, thrombin, kallikreins) and high affinity.AEBSF is a unique molecule that can inhibit serine proteases as well NADPH oxidase, the primary enzyme responsible for catalyzing production of reactive oxygen species in epithelial cells, inflammatory phagocytes. 5Due to these properties, we hypothesized AEBSF might reduce allergic airway inflammation.Recently, it was reported nafamostat mesilate, potent protease inhibitor, inhibits eosinophilic inflammation remodeling murine...
Objective Steroid therapy and olfactory training are common treatments for loss. Systemic steroid treatment is the most effective approach treating sinonasal Olfactory typically sensorineural However, differences in mechanisms of dysfunction unclear. The aim this study was thus to evaluate therapy. Subjects Methods Mice each group were administered 3-methylindole at a dose 300 mg/kg. function evaluated with food-finding test once week. neuroepithelium harvested histologic examination protein...
Exposure to urban particulate matter (UPM) is linked the aggravation of various health problems. Although nasal cavity first barrier encounter UPM, there a lack studies on impact UPM olfactory area. The purpose this study was investigate cytotoxic effects mouse epithelium, underlying pathophysiology involved, and changes in cytokine levels.Mice were divided into 4 groups: control, 400UPM (administered 400 µg daily; standard reference material 1649b; average particle diameter 10.5 μm) 1week,...
Objectives/Hypothesis The increasing number of endoscopic endonasal transsphenoidal approaches (EETSA) has resulted in several sinonasal complications, including voice changes. Here, we compared preoperative and postoperative changes according to age. Methods We retrospectively reviewed the medical records. Patients were divided into following three groups age: ≤ 30 years, 31 60 ≥ years. underwent evaluation using acoustic analysis, a nasometer, handicap index (VHI). A nasometer was used...
Background and Objectives Several studies have reported the benefits of olfactory training (OT) for patients with dysfunction. However, odorants should be customized according to characteristics individual patients. The aim this study was evaluate effects OT using familiar Korean post-upper respiratory infection (URI) Subjects Methods We prospectively evaluated post-URI loss. carried out over a period 6 months four odorants: pine, cinnamon, lemon, peppermint. Olfaction tested before at 1, 3,...
Reconstruction of the skull base using a pedicled nasoseptal flap (NSF) seems to be advantageous after endoscopic endonasal transsphenoidal approach (EETSA). A few reports have evaluated cause failure in EETSA NSFs. The aim this study was evaluate perioperative risk factors for NSF failure.Patient series.Retrospective review medical records at tertiary referral center.The population comprised patients who underwent with elevation between February 2009 and March 2014. authors retrospectively...