A5077002970- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced X-ray and CT Imaging
- Intracranial Aneurysms: Treatment and Complications
- Molecular spectroscopy and chirality
- Radiation Dose and Imaging
- Medical Imaging and Analysis
- Vascular Malformations Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Spectroscopy and Quantum Chemical Studies
- Photoreceptor and optogenetics research
- Intracerebral and Subarachnoid Hemorrhage Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Medical Image Segmentation Techniques
- Head and Neck Surgical Oncology
- Venous Thromboembolism Diagnosis and Management
- Optical Polarization and Ellipsometry
- Craniofacial Disorders and Treatments
- Vascular Malformations and Hemangiomas
- Anatomy and Medical Technology
- Peripheral Artery Disease Management
- Advanced Fluorescence Microscopy Techniques
- Cardiovascular and Diving-Related Complications
- Underwater Vehicles and Communication Systems
University of Tennessee Health Science Center
2019-2023
Siemens Healthcare (United States)
2019-2023
Siemens Healthcare (Germany)
2023
Siemens (United States)
2017-2021
Neurological Surgery
2020
Friedrich-Alexander-Universität Erlangen-Nürnberg
2019
East Carolina University
2012-2013
Circular dichroism (CD), defined as the difference in absorption between left and right circularly polarized light, is used to spectroscopically study structures of chiral materials. In this article, various methodologies are presented for characterizing performance CD spectrometers determine (1) experimental conditions optimal data collection, (2) noise characteristics dependent on machine parameters, (3) relative significance spectral a function detector gain, (4) stray light dark current...
Background Management of large vessel occlusion (LVO) patients after thrombectomy is affected by the presence intracranial hemorrhage (ICH) on post-procedure imaging. Differentiating contrast staining from post-procedural imaging has been facilitated dual-energy computed tomography (DECT), traditionally performed in dedicated (CT) scanners with subsequent delays treatment. We employed a novel method DECT using Siemens cone beam CT (DE-CBCT) angiography suite to evaluate for ICH and...
Abstract Background and Purpose The risk of symptomatic intracranial hemorrhage (ICH) approaches 5% despite mechanical thrombectomy (MT) efficacy for ischemic stroke secondary to large vessel occlusion. Flat‐panel detector CT (FDCT) imaging with Syngo Dyna (Siemens Medical Solutions, Malvern, PA) can be used immediately following MT detect ICH. To evaluate the accuracy reliability FDCT compared conventional post‐MT MRI. Methods Head (20 second, 70 kV) was performed on 26 consecutive...
Both the voltage-induced and inherent (static) birefringence of a photoelastic modulator (PEM) affect phase difference between orthogonal components light passing through PEM. This determines polarization state is essential for determining true circular linear dichroism (CD LD, respectively) spectroscopy. Presented here are more complete theoretical model CD LD new technique to determine static PEM in LD. The intensity various configurations analyzer interpreted (by using Mueller matrices...
Nearly all circular dichroism (CD) and linear (LD) spectrometers use a photoelastic modulator (PEM) in which an optical element is stressed using high-tension voltage (HT) signal to induce birefringence. The birefringence consequently produces phase difference between perpendicular polarization states of light passing through the PEM that appropriate CD or LD measurements. However, even without external stress (i.e., at zero HT) exhibits inherent static This article discusses...
There have been immense advancements in the hardware and software of digital subtraction angiography systems over last several years. These continue to make progress toward goals offering better visualization reducing radiation exposure. A newer advancement this arena is presenting three-dimension data time resulting four-dimensional-digital subtracted visualization. We evaluated these protocols related evaluation treatment intracranial aneurysms with pipeline flow diversion.
Purpose: Medical management after endovascular treatment (EVT) for acute ischemic stroke involves blood pressure and antithrombotic medications which are strongly influenced by hemorrhagic complications of the procedure. In this study our aim is to modify a commercially available c-arm angiographic system assess feasibility distinguishing between iodinated contrast using dual-energy CT technology. Methods: An C-arm was manipulated with addition flat sheet tin (Sn) filtration corresponding...
Introduction: Computed tomography perfusion (CTP) characterizes hemodynamic changes within brain tissue, particularly after stroke. This study aims to quantify cerebral blood volume (CBV) and identify predictors of CBV increase in the pericavity parenchyma minimally invasive intracerebral hemorrhage evacuation (MIS for ICH). Methods: Thirty-two patients underwent MIS ICH with pre/postoperative native CT imaging intraoperative (DynaCT PBV Neuro, Artis Q, Siemens). Scans were segmented using...
<h3>Introduction</h3> The optimal guidelines for post-mechanical thrombectomy (MT) blood pressure (BP) management are not well established. While observational studies have shown benefits of lowering BP in successfully recanalized patients to reduce the risk reperfusion injury, there no randomized trials support this hypothesis. Recanalization may always result and non infarcted area brain occluded arteries' territory can remain hypo-perfused (no-reflow or stunned phenomena). Acute subgroup...
<h3>Introduction</h3> During neurosurgical image-guided procedures, a head clamp, with attached titanium pins, is used to immobilize the head. Titanium chosen for several reasons including cost effectiveness, biocompatibility and fracture resistance. However, titanium's density quite high, creating large dense artifacts on 3D CBCT (Cone Beam CT) images. These hinder visualization of critical anatomy, potential missed information greatly increased. We present an approach redirect caused by...
<h3>Introduction</h3> Flat Panel Imaging in the angiographic suite for patients with Emergent Large Vessel Occlusion (ELVO) can be acquired immediately prior to mechanical thrombectomy (MT). This identifying who no longer need MT after long time delays or due reperfusion IV TPA. Additionally, these techniques may allow angiography serve as initial diagnostic modality and treatment location ELVO. We performed a correlative study on had received both acute stroke CT Angiography (CTA) CTA...
<h3>Introduction</h3> Traditionally angiographic Computed Tomography (CTA) is performed with varying contrast concentrations which can have limiting effects for simultaneous visualization of vasculature, implanted devices, and surrounding tissue. It often challenging to window CTA images visualize low attenuating brain parenchyma high flow diverters or Onyx. Diluting the would reduce gray scale value on vasculature therefore allow visibility tissue simultaneously. However there are no...
<h3>Introduction</h3> Contrast usage for Cone Beam Angiographic Computed Tomography (CBCTA) performance has limited efficacy simultaneous visualization of vasculature, implanted devices, and surrounding tissue. Optimal windowing CBCTA images in order to simultaneously visualize both low attenuating brain parenchyma high flow diverters remains a significant challenge. Appropriate dilution contrast the potential reduce gray scale value on vasculature allow enhanced visibility tissue parent...
<h3>Introduction</h3> Time resolved three-dimensional angiography (4D DSA) was developed initially to investigate parameters related the flow in arterio-venous malformations (AVMs). We have extended this protocol evaluate before and after placement of a diverter for treatment an intracranial aneurysm. Here we prototype 3D iFlow using 4D DSA imaging. <h3>Methods</h3> In study, angiographic imaging (6 s syngo Dyna4D, Siemens Healthineers AG, Forchheim, Germany) performed on 13 patients...