A5001948260- Neuroblastoma Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Cancer therapeutics and mechanisms
- Immunotherapy and Immune Responses
- Glioma Diagnosis and Treatment
- Lung Cancer Research Studies
- Neuroscience and Neuropharmacology Research
- Cancer Genomics and Diagnostics
- Platelet Disorders and Treatments
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Cancer Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- Cancer, Stress, Anesthesia, and Immune Response
- Inflammatory mediators and NSAID effects
- Immunodeficiency and Autoimmune Disorders
- Sarcoma Diagnosis and Treatment
- Cell death mechanisms and regulation
- Mitochondrial Function and Pathology
- Blood Coagulation and Thrombosis Mechanisms
- Microtubule and mitosis dynamics
- Epigenetics and DNA Methylation
- Salivary Gland Tumors Diagnosis and Treatment
- Venomous Animal Envenomation and Studies
BayCare Health System
2022-2024
St. Joseph's Children's Hospital
2021-2024
Nemours Children's Health System
2023-2024
Johns Hopkins University
2023-2024
St. Joseph's Hospital
2024
St. Joseph's Hospital
2024
Children's Hospital of Wisconsin
2023
Medical College of Wisconsin
2003-2023
Johns Hopkins All Children's Hospital
2023
University of South Florida
2023
Although the role of acetylcholine in processing stimuli cerebral cortex is becoming defined, impact cholinergic activity on character cortical maps remains unclear. In somatosensory cortex, topographic appear capable lifelong modifications response to alterations periphery. One factor proposed influence this adaptational ability presence cortex. The studies presented here, using 2-deoxyglucose technique, demonstrate that unilateral removal a digit cats, followed by stimulation an adjacent...
Neuroblastoma (NB) is the most common cancer in infancy and frequent cause of death from extracranial solid tumors children. Ornithine decarboxylase (ODC) expression an independent indicator poor prognosis NB patients. This study investigated safety, response, pharmacokinetics, genetic metabolic factors associated with ODC a clinical trial inhibitor difluoromethylornithine (DFMO) ± etoposide for patients relapsed or refractory NB.
Abstract High risk neuroblastoma (HRNB) accounts for 15% of all pediatric cancer deaths. Despite aggressive therapy approximately half patients will relapse, typically with only transient responses to second-line therapy. This study evaluated the ornithine decarboxylase inhibitor difluoromethylornithine (DFMO) as maintenance prevent relapse following completion standard (Stratum 1) or after salvage relapsed/refractory disease 2). Phase II single agent, arm multicenter enrolled from June 2012...
Long-term survival in high-risk neuroblastoma (HRNB) is approximately 50%, with mortality primarily driven by relapse. Eflornithine (DFMO) to reduce risk of relapse after completion immunotherapy was investigated previously a single-arm, phase II study (NMTRC003B; ClinicalTrials.gov identifier: NCT02395666) that suggested improved event-free (EFS) and overall (OS) compared historical rates III trial (Children Oncology Group ANBL0032; NCT00026312). Using patient-level data from ANBL0032 as an...
Neuroblastoma is a sympathetic nervous system tumor, primarily presenting in children under 6 years of age. The long-term prognosis for patients with high-risk neuroblastoma (HRNB) remains poor despite aggressive multimodal therapy. This report provides an update to phase II trial evaluating DFMO as maintenance therapy HRNB. Event-free survival (EFS) and overall (OS) 81 subjects HRNB treated standard COG induction, consolidation immunotherapy followed by 2 on the NMTRC003/003b Phase were...
Children with relapsed central nervous system (CNS tumors), neuroblastoma, sarcomas, and other rare solid tumors face poor outcomes. This prospective clinical trial examined the feasibility of combining genomic transcriptomic profiling tumor samples a molecular board (MTB) approach to make real‑time treatment decisions for children relapsed/refractory tumors. Subjects were divided into three strata: stratum 1-relapsed/refractory neuroblastoma; 2-relapsed/refractory CNS tumors;...
Background Evidence suggests early lymphocyte recovery after chemotherapy predicts superior outcome for patients with cancer, a phenomenon not previously investigated in osteosarcoma. This study determined the prognostic significance of pediatric Procedures We reviewed data 19 consecutive treated osteosarcoma at our institution from 1997 to 2007. After initial chemotherapy, were separated into two groups: versus late recovery, using threshold absolute count ≥800 cells/µl on day 14 (ALC-14)....
Abstract The role of acetylcholine (ACh) in cerebral cortical activity has recently been reevaluated. It now seems clear that this neurotransmitter increases the magnitude responses. Although substantial information gathered regarding ACh sensory processing, little is known about participation organization maps cortex. To address issue, we used 2 methods to manipulate supply somatosensory cortex cats: (1) unilateral neurotoxic lesions basal forebrain and (2) topical applications cholinergic...
Abstract The primary objective of the study was to evaluate feasibility and safety a process which would utilize genome‐wide expression data from tumor biopsies support individualized treatment decisions. Current options for recurrent neuroblastoma are limited ineffective, with survival rate <10%. Molecular profiling may provide will enable practitioner select most appropriate therapeutic option individual patients, thus improving outcomes. Sixteen patients were enrolled fourteen eligible...
Abstract Current therapeutic options for recurrent neuroblastoma have poor outcomes that warrant the development of novel strategies. Specificity protein (Sp) transcription factors regulate several genes involved in cell proliferation, survival, and angiogenesis. Sp1 regulates believed to be important determinants biological behavior neuroblastoma. Tolfenamic acid (TA), a non‐steroidal anti‐inflammatory drug, is known induce degradation Sp proteins may serve as anti‐cancer agent. The...
Medulloblastoma (MB) is the most common malignancy in children arising brain. Morbidities associated with intensive therapy are serious concerns treating MB. Our aim was to identify novel targets and agents less toxicity for Specificity protein 1 (Sp1) transcription factor regulates several genes involved cell proliferation survival including survivin, an inhibitor of apoptosis protein. We previously showed that tolfenamic acid (TA), a nonsteroidal anti-inflammatory drug, inhibits...
Background The primary aim of this Phase I study was to determine the maximum tolerated dose (MTD) TPI 287 and safety tolerability alone in combination with temozolomide (TMZ) pediatric patients refractory or recurrent neuroblastoma medulloblastoma. secondary aims were evaluate pharmacokinetics treatment responses. Procedure Eighteen enrolled a phase escalation trial weekly intravenous infusion for two 28‐day cycles toxicity monitoring MTD, followed by TMZ. Samples collected pharmacokinetic...
Abstract Stimulus‐evoked metabolic activity in the anterior parietal cortex (areas 3a, 3b, 1, and 2) occurs form of column‐like patches. Similar patches characterize connections to, within, from these fields. The relation elicited metabolically to those formed by retrograde or anterograde transport, however, is not clear. If a type projection connecting areas 2 transmits sensory information among cortical fields, resultant pattern may directly contribute definition somatosensory “columns.”...
Little is known about the risk of post-COVID-19 multisystem inflammatory syndrome in children (MIS-C) setting childhood cancer.
Background/Aims: The small molecule, Tolfenamic acid (TA) has shown anti-cancer activity in pre-clinical models and is currently Phase I clinical trials at MD Anderson Cancer Center Orlando. Since specificity toxicity are major concerns for investigational agents, we tested the effect of TA on specific targets, assessed cellular organismal representing studies cancer. Methods: Panc1, L3.6pl, MiaPaCa-2 (pancreatic cancer), hTERT-HPNE(normal), differentiated/un-differentiated SH-SY5Y...
Abstract Children with treatment-refractory or relapsed (R/R) tumors face poor prognoses. As the genomic underpinnings driving R/R disease are not well defined, we describe here and transcriptomic landscapes of solid from 202 patients enrolled in Beat Childhood Cancer Consortium clinical trials. Tumor mutational burden (TMB) was elevated relative to untreated at diagnosis, one-third classified as having a pediatric high TMB. Prior chemotherapy exposure influenced landscape these tumors, more...
Background: Neuroblastoma is the most common extracranial solid tumor in children, and treatment options for recurrent neuroblastoma are limited. Using molecular profiling to target vulnerabilities of with existing therapeutic agents may result a rational, data-driven approach potential improve clinical outcomes. Methods: The primary objective this pilot study was evaluate feasibility supporting real-time decisions through predictive modeling genome-wide mRNA gene expression data from...
Malignant ectomesenchymoma is a rare tumor arising from mature ganglion cells with immature myogenous elements, only 4 pediatric intracranial cases having been previously reported. The authors report case of malignant originating the falx cerebri in 10-year-old boy. patient presented 2-week history headache, nausea, and blurry vision, mild lateral gaze diplopia. A CT scan revealed solitary 7.2 × 3.8-cm dural-based mass that extended along falx. No metastatic disease was identified, lesion...
Secondary myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML) is a rare but devastating complication of solid tumor treatment involving high-dose topoisomerase II inhibitor and alkylator chemotherapy. For relapsed or elderly MDS AML patients ineligible for hematopoietic stem cell transplantation, epigenetic therapies, including DNA methyltransferase inhibitors histone deacetylase inhibitors, have been utilized as palliative therapy, offering well-tolerated approach to disease...