A5113159470- Advanced MRI Techniques and Applications
- Advanced NMR Techniques and Applications
- Influenza Virus Research Studies
- Metallurgy and Material Forming
- NMR spectroscopy and applications
- Protein Structure and Dynamics
- RNA and protein synthesis mechanisms
- Electron Spin Resonance Studies
Max Planck Institute for Multidisciplinary Sciences
2023-2024
The currently circulating S31N variant of the M2 proton channel influenza A is resistant to antiviral drugs. Recently, there has been a growing concern regarding impact lipid environment on structural features variant. native symmetry tetramer remains controversial. Here we show that persists in dimer-of-dimers structurein different preparations independent amount solvating lipids up at least 180 per tetramer. Two isoleucine residues with upfield shifted alpha carbon resonances, which are...
Inspired by the recently proposed transverse mixing optimal control pulses (TROP) approach for improving signal in multidimensional magic-angle spinning (MAS) NMR experiments, we present simplified preservation of equivalent pathways spectroscopy (SPEPS). It transfers both components magnetization that occur during indirect evolutions, theoretically enabling a √2 improvement sensitivity each such dimension. We compare SPEPS transfer with TROP and cross-polarization (CP) using membrane...
Inspired by the recently proposed Transverse mixing Optimal control Pulses (TROP) approach for improving signal in multi-dimensional magic-angle spinning (MAS) NMR experiments, we present simplified preservation of equal paths spectroscopy (SPEPS). It transfers both transverse components magnetization that occur during indirect evolutions, theoretically enabling a √2 improvement sensitivity each such dimension. We compare SPEPS transfer with TROP and cross polarization (CP) using membrane...
Abstract The currently circulating S31N variant of the M2 proton channel influenza A is resistant to antiviral drugs. Recently, there has been a growing concern regarding impact lipid environment on structural features variant. native symmetry tetramer remains controversial. Here we show that persists in dimer‐of‐dimers structure different preparations independent amount solvating lipids up at least 180 per tetramer. NMR spectra clearly detect characteristic resonances (residues 18–60 or...
Theoretical and simulated analyses of selective homonuclear dipolar recoupling sequences serve as primary tools for understanding determining the robustness these under various conditions. In this article, we investigate recently proposed first-order sequence known MODIST (Modest Offset Difference Internuclear Selective Transfer). We evaluate transfer efficiency, assessing its dependence on rf-field strengths number spins, extending up to 10 spins. This helps identify conditions that enhance...