A5028523297- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- vaccines and immunoinformatics approaches
- Animal Virus Infections Studies
- Viral Infections and Outbreaks Research
- Bacteriophages and microbial interactions
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 detection and testing
- Mosquito-borne diseases and control
- COVID-19 epidemiological studies
- COVID-19 diagnosis using AI
- Thyroid Cancer Diagnosis and Treatment
- Virology and Viral Diseases
- Gastric Cancer Management and Outcomes
- Ovarian cancer diagnosis and treatment
- Bacillus and Francisella bacterial research
- Gastrointestinal Tumor Research and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Obesity, Physical Activity, Diet
- Evolution and Genetic Dynamics
- Virus-based gene therapy research
- Thyroid Disorders and Treatments
- Enhanced Recovery After Surgery
- Vector-borne infectious diseases
- Heparin-Induced Thrombocytopenia and Thrombosis
Università Cattolica del Sacro Cuore
2024-2025
Università Campus Bio-Medico
2019-2024
University of Rome Tor Vergata
2022-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2022
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
2022
Medico
2020
MIND Research Institute
2020
Cornell University
2020
Weill Cornell Medicine
2020
Dokuz Eylül University
2020
Coronavirus disease 2019 (COVID-2019) has been recognized as a global threat, and several studies are being conducted using various mathematical models to predict the probable evolution of this epidemic. These based on factors analyses subject potential bias. Here, we propose simple econometric model that could be useful spread COVID-2019. We performed Auto Regressive Integrated Moving Average (ARIMA) prediction Johns Hopkins epidemiological data trend prevalence incidence For further...
Abstract Last December 2019, a new virus, named novel Coronavirus (COVID‐2019) causing many cases of severe pneumonia was reported in Wuhan, China. The virus knowledge is limited and especially about COVID‐2019 pathogenesis. Open Reading Frame 1ab (ORF1ab) has been analyzed to evidence the presence mutation caused by selective pressure on virus. For analysis fast‐unconstrained Bayesian approximation (FUBAR) used. Homology modelling performed SwissModel HHPred servers. transmembrane helical...
A novel Coronavirus, 2019-nCoV, has been identified as the causal pathogen of an ongoing epidemic, with first cases reported in Wuhan, China, last December 2019, and since spread to other countries worldwide, included Europe very recently Italy. In this short report, phylogenetic reconstruction was used better understand transmission dynamics virus from its introduction China focusing on more recent evidence infection a couple Chinese tourists arrived Italy 23rd January 2020 labeled...
The global spread of the 2019-nCoV is continuing and fast moving, as indicated by WHO raising risk assessment to high. In this article, we provide a preliminary phylodynamic phylogeographic analysis new virus. A Maximum Clade Credibility tree has been built using 29 available whole genome sequences two that are highly similar from Bat SARS-like Coronavirus in GeneBank. We able clarify mechanism transmission among countries which have provided sequence isolates their patients. Bayesian...
The Coronavirus Disease 2019 (COVID-19) is a new viral infection caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2). Genomic analyses have revealed that SARS-CoV-2 related to Pangolin and Bat coronaviruses. In this report, structural comparison between Sars-CoV-2 Envelope Membrane proteins from different human isolates with homologous closely viruses described. here reported show high similarity of counterparts isolates. However, comparisons also highlighted differences...
Lineage B.1.617+, also known as G/452R.V3 and now denoted by WHO with the Greek letters δ κ, is a recently described SARS-CoV-2 variant under investigation first identified in October 2020 India. As of May 2021, three sublineages labeled B.1.617.1 (κ), B.1.617.2 (δ), B.1.617.3 have been already identified, their potential impact on current pandemic being studied. This has 13 amino acid changes, its spike protein, which are currently particular concern: E484Q, L452R, P681R. Here, we report...
Abstract There is concern about a new coronavirus, the 2019-nCoV, as global public health threat. In this article, we provide preliminary evolutionary and molecular epidemiological analysis of virus. A phylogenetic tree has been built using 15 available whole genome sequence 2019-nCoV 12 sequences highly similar in gene bank (5 from SARS, 2 MERS 5 Bat SARS-like Coronavirus). FUBAR shows that Nucleocapsid Spike Glycoprotein some sites under positive pressure while homology modelling helped to...
Abstract Recombination is the main contributor to RNA virus evolution, and SARS‐CoV‐2 during pandemic produced several recombinants. The most recent recombinant lineage labeled XBB, also known as Gryphon, which arose from BJ.1 BM.1.1.1. Here we performed a genome‐based survey aimed compare new with its parental lineages that never became dominant. Genetic analyses indicated XBB first descendant XBB.1 show an evolutionary condition typical of blind background no further epidemiologically...
Background. Metabolic syndrome (MetS) and nephrolithiasis (NL) are quite common disorders. While some of the components MetS have been proposed as precursors NL in population studies, no data available about possible association between such. The primary objective study was to evaluate relationship NL. secondary outcome examine single constitutive elements considering strict correlation occurring among these factors. Methods. We studied 2132 Caucasian inpatients 'Spinelli' Hospital southern...
Abstract The emergence of the novel betacoronavirus, recently renamed as severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has raised serious concerns due to virus's rapid dissemination worldwide. Nevertheless, there is limited information about genomic epidemiology SARS‐CoV‐2 circulating in Italy from surveillance studies. shortage complete sequences available impairs our understanding introduction and establishment country. To better understand its dynamics Italy, we analyzed...
Measles, a highly contagious disease primarily affecting children, carries serious health risks, including complications and mortality. Vaccination remains the most effective preventive measure against measles transmission. The COVID-19 pandemic has exacerbated challenges in surveillance immunization efforts, leaving millions of people exposed to preventable diseases such as measles. Globally accelerated campaigns are critical for achieving regional elimination goals mitigating risk...
Ceramides are sphingolipids that modulate a variety of cellular processes via 2 major mechanisms: functioning as second messengers and regulating membrane biophysical properties, particularly lipid rafts, important signaling platforms. Altered sphingolipid levels have been implicated in many cardiovascular diseases, including hypertension, atherosclerosis, diabetes mellitus-related conditions; however, molecular mechanisms by which ceramides impact endothelial functions remain poorly...
The BQ.1 SARS-CoV-2 variant, also known as Cerberus, is one of the most recent Omicron descendant lineages. Compared to its direct progenitor BA.5, has some additional spike mutations in key antigenic sites, which confer further immune escape ability over other circulating In such a context, here, we perform genome-based survey aimed at obtaining complete-as-possible nuance this rapidly evolving subvariant. Genetic data suggest that represents an evolutionary blind background, lacking rapid...
To compare the vaginal cuff dehiscence (VCD) rates using Vicryl (Poliglactyn 910) and Polydioxanone (PDS) in patients who underwent laparoscopic hysterectomy.
Abstract Early diagnosis and treatment significantly reduce sepsis mortality. Currently, no gold standard has been yet established to diagnose outside the ICU. The aim of study was evaluate diagnostic accuracy defined by SIRS Criteria 1991, Second Consensus Conference 2001, modified 2001 (obtaining SOFA score), Third 2016, in addition dosage Procalcitonin (PCT) MR-pro-Adrenomedullin (MR-proADM). In this prospective study, 209 consecutive patients with clinical were enrolled (May 2014–June...